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Entry version 13 (10 Feb 2021)
Sequence version 1 (12 Apr 2017)
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Protein
Submitted name:

coiled-coil domain-containing protein 180

Gene

LOC106172963

Organism
Lingula unguis
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
coiled-coil domain-containing protein 180Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOC106172963Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLingula unguisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7574 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaSpiraliaLophotrochozoaBrachiopodaLinguliformeaLingulataLingulidaLinguloideaLingulidaeLingula
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000085678 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini136 – 597DUF4455InterPro annotationAdd BLAST462
Domaini1207 – 1412DUF4456InterPro annotationAdd BLAST206

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni602 – 650DisorderedSequence analysisAdd BLAST49
Regioni1100 – 1166DisorderedSequence analysisAdd BLAST67
Regioni1323 – 1345DisorderedSequence analysisAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili451 – 471Sequence analysisAdd BLAST21
Coiled coili501 – 521Sequence analysisAdd BLAST21
Coiled coili800 – 820Sequence analysisAdd BLAST21
Coiled coili902 – 922Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi602 – 623PolyampholyteSequence analysisAdd BLAST22
Compositional biasi1100 – 1119PolyampholyteSequence analysisAdd BLAST20
Compositional biasi1140 – 1166PolarSequence analysisAdd BLAST27

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
47728at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026701, CCDC180
IPR028089, DUF4455
IPR027914, DUF4456

The PANTHER Classification System

More...
PANTHERi
PTHR21444:SF14, PTHR21444:SF14, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14643, DUF4455, 1 hit
PF14644, DUF4456, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1S3JHJ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMAETQAIRV VPSGKIYRQI FDSQVQLANV LEKTSEERTK KGVKIVERPG
60 70 80 90 100
GIPVVKEKRH ITEGTGILSQ RQKTWIEGFP NDYSTENPVL YKQVTEFTNQ
110 120 130 140 150
KLAEPESSVV GREVRGLPDI VVAAKPGSDI IQRIADSRRE RHERALEDMH
160 170 180 190 200
QELGVITADL EPSIIEAGEK LMSMLKENDQ EIDLLMSRIE SDENLLTLTL
210 220 230 240 250
TELHEIWDAI QSQTSLRRGG IEELDSTLSE VEDDRMERIR KVFSEYAETL
260 270 280 290 300
EKISHLMAPD LSRLMDMESQ AINQSVLSNR RSYADLFGRL MTTDIEREKK
310 320 330 340 350
QHTLWTRRVQ DWRTLNIQQA NEKFQNFMSS EAVVRPQGAQ KVLELMKTEQ
360 370 380 390 400
GSLNERRLRL ISSLKELKPP ASTKTAVYHW NEKVVALSEQ IDALNQGYLE
410 420 430 440 450
RLHSEYEEVC QLCLEEVEKA RKKLISSGVC SEQKATEVIE ESFLPLVGDR
460 470 480 490 500
QKLFEQELED MDKQLEEHND MLMIHLKSLF KFAQGAAHVW DVHEIGLAKQ
510 520 530 540 550
ERSLQEKLES CRHQHDNQNQ EKEGNLDIIM DRMRQDATET ALKESLKKAM
560 570 580 590 600
DMLDKIRNGY ESFHEEQMAV VRSYPEMVKD ELDNYDHTVC KFFSVDRRHP
610 620 630 640 650
DDVEAKDEEE TTKSKEGLTP RSKGKSRRKS KKSDRPGSRT SEGDKSPLPM
660 670 680 690 700
AVSEILSTAR GTAFFVLTVA GEFSGHPDDP RSSVEPPGST FLTESVLPKV
710 720 730 740 750
LPPYLASVDV SEEFLAEVKK GIRMNFLDHL EEWSEEAMER SRSVVAAKIE
760 770 780 790 800
ELNSELDLRL HLHQPRTRRA ELDVHNVRAA ELVMHSERVT RHCKGINHSL
810 820 830 840 850
TELKQQFAKM THEHDKLASK FREGIEALEV VFINATKSAK LVALQNRLQE
860 870 880 890 900
ELDKFMSVIR ASLRQFRQHL DDTLAMLRQS NAKFIKSFKL FSDGGNFCPE
910 920 930 940 950
EIDEYRKKLE KMSQKIDAAE GFIMADLEGM ESKRLDQATK VASEFEDRFK
960 970 980 990 1000
NHMFDLIFME KIARWLTNTQ VKIKAEVADS NTQAQRLAQF LNDLDRRIDA
1010 1020 1030 1040 1050
CEKPNLDKEQ VSPTQLNNSL KAIFEAFHSR SQYLNSLKDP NTIRPQSATM
1060 1070 1080 1090 1100
QGAPALGARV GFAVDTGVPA ISKAGKQPAE DPSISTIKNI LKTQKTKLRF
1110 1120 1130 1140 1150
GPDADLDGEV TEKERQTKSM SRPPTQGTAI MEAKSVGTKH SRKGTATTAT
1160 1170 1180 1190 1200
SDPTRRSQSA VRRSTYGSNK MKIDKRFLIF GEKDEEGEES HFLGKIRHTL
1210 1220 1230 1240 1250
REALDGLLTT AELYYRQKGS RPVTRPQALQ ETFEQCAEIV VQKLESYYKQ
1260 1270 1280 1290 1300
ADEYHNQCLQ EFRSQLTHLE QLIARVPPLV INEIAKTHIQ KAHQVRKEID
1310 1320 1330 1340 1350
EAFQQQLEKW NSKKYEHKNL LRPTLGHPHQ HHQMKSLCDE EESRRTDYIQ
1360 1370 1380 1390 1400
GVQGHHSKQQ QSSVEHAEEF IAQLASASEQ LLLQFDNLLT VDDVEKGRVD
1410 1420 1430 1440 1450
PKKYPTSELI RRRAAGVPLE DEEDKNALPR GKGTWQGIVK NELVCGDKPD
1460 1470 1480 1490 1500
KPKLTASVNT AKTTLGHSAA VTARDQAYQD YKKQFEKTLH SIEEQKLTWL
1510 1520
NEEQRWTDSW QSSVEKVVQL YKT
Length:1,523
Mass (Da):174,347
Last modified:April 12, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i458CD6716C20F31B
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_013409374.1, XM_013553920.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
106172963

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
lak:106172963

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_013409374.1, XM_013553920.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi106172963
KEGGilak:106172963

Phylogenomic databases

OrthoDBi47728at2759

Family and domain databases

InterProiView protein in InterPro
IPR026701, CCDC180
IPR028089, DUF4455
IPR027914, DUF4456
PANTHERiPTHR21444:SF14, PTHR21444:SF14, 1 hit
PfamiView protein in Pfam
PF14643, DUF4455, 1 hit
PF14644, DUF4456, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1S3JHJ7_LINUN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1S3JHJ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: February 10, 2021
This is version 13 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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