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Entry version 18 (10 Feb 2021)
Sequence version 1 (12 Apr 2017)
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Protein
Submitted name:

centrosomal protein of 295 kDa

Gene

LOC106151994

Organism
Lingula unguis
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
centrosomal protein of 295 kDaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOC106151994Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLingula unguisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7574 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaSpiraliaLophotrochozoaBrachiopodaLinguliformeaLingulataLingulidaLinguloideaLingulidaeLingula
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000085678 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2228 – 2371ALMS_motifInterPro annotationAdd BLAST144

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni328 – 501DisorderedSequence analysisAdd BLAST174
Regioni530 – 558DisorderedSequence analysisAdd BLAST29
Regioni600 – 734DisorderedSequence analysisAdd BLAST135
Regioni766 – 886DisorderedSequence analysisAdd BLAST121
Regioni904 – 944DisorderedSequence analysisAdd BLAST41
Regioni963 – 1010DisorderedSequence analysisAdd BLAST48
Regioni1030 – 1205DisorderedSequence analysisAdd BLAST176
Regioni1230 – 1261DisorderedSequence analysisAdd BLAST32
Regioni1296 – 1427DisorderedSequence analysisAdd BLAST132
Regioni1475 – 1540DisorderedSequence analysisAdd BLAST66
Regioni1619 – 1642DisorderedSequence analysisAdd BLAST24
Regioni1779 – 1807DisorderedSequence analysisAdd BLAST29
Regioni2033 – 2071DisorderedSequence analysisAdd BLAST39
Regioni2096 – 2122DisorderedSequence analysisAdd BLAST27
Regioni2180 – 2212DisorderedSequence analysisAdd BLAST33
Regioni2253 – 2325DisorderedSequence analysisAdd BLAST73
Regioni2338 – 2378DisorderedSequence analysisAdd BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili36 – 86Sequence analysisAdd BLAST51
Coiled coili219 – 246Sequence analysisAdd BLAST28
Coiled coili256 – 276Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi408 – 449PolyampholyteSequence analysisAdd BLAST42
Compositional biasi450 – 482PolarSequence analysisAdd BLAST33
Compositional biasi600 – 616PolyampholyteSequence analysisAdd BLAST17
Compositional biasi623 – 640Pro-richSequence analysisAdd BLAST18
Compositional biasi787 – 835PolarSequence analysisAdd BLAST49
Compositional biasi872 – 886PolarSequence analysisAdd BLAST15
Compositional biasi905 – 928PolarSequence analysisAdd BLAST24
Compositional biasi984 – 1004PolarSequence analysisAdd BLAST21
Compositional biasi1043 – 1057PolarSequence analysisAdd BLAST15
Compositional biasi1318 – 1343PolarSequence analysisAdd BLAST26
Compositional biasi1359 – 1398PolarSequence analysisAdd BLAST40
Compositional biasi1619 – 1638PolarSequence analysisAdd BLAST20
Compositional biasi2040 – 2071PolyampholyteSequence analysisAdd BLAST32
Compositional biasi2098 – 2115PolarSequence analysisAdd BLAST18
Compositional biasi2269 – 2317PolarSequence analysisAdd BLAST49

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
944375at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029299, ALMS_motif

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15309, ALMS_motif, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1S3H5Z9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKSKVSRYR LSPNEVDQLV KEEKQKRRIA RIVQVREQAK ADAAKVRQAV
60 70 80 90 100
KDARAKELQK LAEEIMDEYE KEKAEKIHEL ETLYENCLKT IGEGHREAEQ
110 120 130 140 150
FDDKAEEVYI KLREDTKMAD MRHKKALAKV KRDKALKDQE ENKHIVARQL
160 170 180 190 200
ALEQERVRAA MIASLPPPPP DPLVLQLDTT KVKPVQLTDV DAFSTTHYHL
210 220 230 240 250
QEDYIVDRAD REEWGDAKAA ATEEAERIAE RQLKDLRSNQ EQTEKARLRH
260 270 280 290 300
QHAVQQEILK EDYKNLLVHL AELERADILK RQHLVANIPK KIFLPPSKRL
310 320 330 340 350
EEKTDRQGGL ERAFEDMYLA ETDYTGDVTL ALDPHPPPDS PSTTASLDLS
360 370 380 390 400
EVEEGPKTYP RLQPTQTGPE AYPRSGVTPP QSYPRPQAAA SRVPALQDVT
410 420 430 440 450
NVPLAEKMSR DQKNESMLKK LMEKIKSQRD SWKTRADLPE PDSETLRKPL
460 470 480 490 500
KTSESSSSGV TSTATLSQHT ITSNSSEDGA TGPQPHTDVG GLDVPKQTDM
510 520 530 540 550
DVPEFQEEPI LAGSPETLRH PLEEAARMRA HAARQRAEVE AKQQVPATAP
560 570 580 590 600
PVADKEVPTE LIAETNRKME EEAAQQQEHL RQQRLQLEQY IREIEERKQQ
610 620 630 640 650
LEDRRKHLEE REGIETEPTP AQSTPAQPTP AQPTPAKPTP TDPKTQGAED
660 670 680 690 700
RRSPAGYEAY RYTDTTGDVG AQPSPQPLQP PGGLPQPDQP LGEDQTSSDK
710 720 730 740 750
EEKPQSDKQP PTSGLSSAPT YLPSLYADRS EEQVGKIRDY QRQLLERHAQ
760 770 780 790 800
GRAELEAQRG ALERRREALM GKYPGLGFRD IETKGKGQQP PVSSQVPPSS
810 820 830 840 850
TVTRQPPVSQ PIEKQYPSVS SASIPPISAV TRQPVMSQPM EEKHIQVPVS
860 870 880 890 900
HQQQQEEQSP KQQKEIHQLQ QERLRQQQQL IQQQQQLKEQ QRLLELRKQE
910 920 930 940 950
QEKLQQQQFL KARQPEEPQQ QQPLQMPWQP GYQLPPPSLL PRSEAVPFGQ
960 970 980 990 1000
GVVYNRQTGE LIQTAALSSQ GTGDEEEEEG SSSEWSSGRQ MAQQVPSPTW
1010 1020 1030 1040 1050
RQGDQNPRLE HLKQQLEAIR AERERVLLRQ QQSEEQLRQQ RERYQRLFPN
1060 1070 1080 1090 1100
SAQKLTPEEP MQPDHVPDED WPGLGPVHRS SMLGERTLGG QGERSLSYGI
1110 1120 1130 1140 1150
EQRSSLQGER SLEDQGERSP EGQVEGQVYR HSKVRGPPPV VKRVGFTEDS
1160 1170 1180 1190 1200
MAHELSTIQE VDTPRSVRSG GGRSVLGSPL TPQGQPPTPQ GHPFRSQGQW
1210 1220 1230 1240 1250
VPGVSTVMPV PQRSVDRQYQ QWGSLLAGGA DLQQQDEPIH AQVTRSDGRS
1260 1270 1280 1290 1300
PPAPPRFLSQ GAGALSAVAP VSHGVPAEAG ELPLYSTDVG RGVLLYPDAR
1310 1320 1330 1340 1350
PQVPEHPQGV TRGVDHSGRP GSVSSNENTI STGPVSSEEN LLTDPQQEFH
1360 1370 1380 1390 1400
RQDESYNTLA PLKPDSSPGS LSTLSQQYTR GQDVTPAKTD QSPGSEGSKF
1410 1420 1430 1440 1450
GVNRREIEGA DNRLYHQQPF PGASPNYELD SYKQFVSGVH KPSAADVSYS
1460 1470 1480 1490 1500
QYRDKHGSPQ GADVAHAQYD DKYSGGLQVQ PGLPQFPYGN SVGSGTYGAP
1510 1520 1530 1540 1550
QGRLGSEPAL PDSPHYPQYS GPEQGGGYSE TWGRWGDFSR TENGAVPATV
1560 1570 1580 1590 1600
APTGGVSSVT EPAMVGAYGG IGVMPSLPQY HQSGLRPSFS PTIGGRSALE
1610 1620 1630 1640 1650
EREVVDSSSL SYYPITPSVD SGGIDMTSGQ GQGQGRDDSQ HSRSYDVYHA
1660 1670 1680 1690 1700
QMEMSRTQPT SFPFLQKGLY PSVDSSFDPG IPSVKEGIVS GELKPLAAEH
1710 1720 1730 1740 1750
SLTSDLSGLV PPNKAAIVPD ANLVQLFSTK DNLVLHGTQG MGKPGGKNAS
1760 1770 1780 1790 1800
FLSDVSQHPL TSDISEASQY PLSGFQEEPS VYMQDDPSPA AGSHTPGHRV
1810 1820 1830 1840 1850
HSEPEPQTVD WTQLQQQNTG FGSLSPVHAE FEEIGQSSRG IVWSPGGDSD
1860 1870 1880 1890 1900
LYPPEGNRSF TSPRGAMLPL RTVSLPEQSM STMVSDFSHR SLSQHSLTGM
1910 1920 1930 1940 1950
DDTDQFTTAG EHRREAEPVS VIPSQSELLL LQEGYSPGAL IIGTQEQRDL
1960 1970 1980 1990 2000
SSNNNNSNIE QGVRELFTET CPPTSVSLEP SQVNTMTAVD GRSDQWNVFS
2010 2020 2030 2040 2050
KSERSSAAEN MDDRYQQLLL QARELNQQLR QQLGTEQTDD LDQKASDLDP
2060 2070 2080 2090 2100
EENSASTDRR ADEEAPAERR VSEKYEALVE EARLLKNKLL ADMRHDGRGS
2110 2120 2130 2140 2150
VTSSQDTSIW SSHPQDGQEK PGAWHSLEEM TGISEEPDLT LVSLVSEPAT
2160 2170 2180 2190 2200
ADSSVHLDQS LSMEDSLRSF QQHEMRIASA EATPGQGGVR RDGLEIIPPA
2210 2220 2230 2240 2250
EGGGAGLEGS SSCPIRAVEE TNRDRREASL QEAFARKRPD FAQKSKERLQ
2260 2270 2280 2290 2300
AIESKKDAKA LTGGPTAARN AQLAKTVSSW KKLRSAKASE KQQSPVQSLK
2310 2320 2330 2340 2350
PSEGRVQVVT KSTTDRQQDV KAMYDRNRRL YEGLEEVKQK KAEKEREDQR
2360 2370
RVNRQRAKEF QKKTLAKIRK KEGDSSKE
Length:2,378
Mass (Da):263,450
Last modified:April 12, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCB33B257398103E8
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_013380901.1, XM_013525447.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
106151994

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
lak:106151994

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_013380901.1, XM_013525447.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi106151994
KEGGilak:106151994

Phylogenomic databases

OrthoDBi944375at2759

Family and domain databases

InterProiView protein in InterPro
IPR029299, ALMS_motif
PfamiView protein in Pfam
PF15309, ALMS_motif, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1S3H5Z9_LINUN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1S3H5Z9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: February 10, 2021
This is version 18 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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