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UniProtKB - A0A1S3GZX9 (A0A1S3GZX9_LINUN)

Entry version 18 (10 Feb 2021)
Sequence version 1 (12 Apr 2017)
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Protein

Angiotensin-converting enzyme

Gene

LOC106150791

Organism
Lingula unguis
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCarboxypeptidaseUniRule annotation, Hydrolase, MetalloproteaseUniRule annotation, Protease
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Angiotensin-converting enzymeUniRule annotation (EC:3.4.-.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOC106150791Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLingula unguisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7574 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Spiralia › Lophotrochozoa › Brachiopoda › Linguliformea › Lingulata › Lingulida › Linguloidea › Lingulidae › Lingula
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000085678 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501454568517 – 659Angiotensin-converting enzymeSequence analysisAdd BLAST643

Keywords - PTMi

GlycoproteinUniRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili87 – 114Sequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M2 family.UniRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...OMAi		IQKFQWR

Database of Orthologous Groups

More...OrthoDBi		422699at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd06461, M2_ACE, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001548, Peptidase_M2

The PANTHER Classification System

More...PANTHERi		PTHR10514, PTHR10514, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01401, Peptidase_M2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00791, PEPDIPTASEA

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1S3GZX9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLAIFTLLL VTGALCRSDE ELREQLIDML EDAFKVDKFS DGKFDAGVEE 
        60         70         80         90        100
KAEAWLKDYN TKLAVRSGIA CNLNWNYETN ISNANAKKIE NNQVEQAEWN 
       110        120        130        140        150
RKKAQEAREW LKKKTSKFSE DTLRQFKLIT MDASLRDDAD VRRMSYLLSQ 
       160        170        180        190        200
MESIYDKGKV CRPHSEASCL PLEPDLVNLM MTSRDYDELL WAWKSWRDVT 
       210        220        230        240        250
GPPIRDLYRE FVVFQNKAAK ENGFADMGEF WRISNFEDKN LDKIVDGLFD 
       260        270        280        290        300
QVKPLYQQLH AYVRRKLINQ YGEKYVSPTG PIPAHLLGNM WAQQWDLILD 
       310        320        330        340        350
LLQPYPNVPS VDVTSALKKQ NYTVQKMFKT AEAFFCSLGM DNMTKEFWEK 
       360        370        380        390        400
SMVVKPTDGR EVQCHASAED FHNASDYRIK MCTEIDYDNL YVIHHEMGHV 
       410        420        430        440        450
QYYMQYSHQP DIYRNGANAG FHEAVGDTIA LSVATPEHLH KLKLLDDIGD 
       460        470        480        490        500
DKELREKQDL NFLMKMALQK LAFLPFGLLI DKWRWDVFRG HTNASNYNQK 
       510        520        530        540        550
WWDLRLRYQG IAPPVPRSEL DFDPGAKFHV PANVPYIRYF VSFLIQFQFQ 
       560        570        580        590        600
RALCDAAGHT GPIHHCDIYQ STAAGEKLKK MLSLGSSRPW PDAMEVLTGQ 
       610        620        630        640        650
REIDPSAILE YFKPLQDFLV KENKNEIIGW EENSEDLMAG LQDDALEELK 

HLFEELDSE
Length:659
Mass (Da):76,512
Last modified:April 12, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAAEC71F4A60103B2
GO

Sequence databases

NCBI Reference Sequences

More...RefSeqi		XP_013379232.1, XM_013523778.1
XP_013379234.1, XM_013523780.1
XP_013379235.1, XM_013523781.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		g21979.t1; g21979.t1; g21979

Database of genes from NCBI RefSeq genomes

More...GeneIDi		106150791

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		lak:106150791

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_013379232.1, XM_013523778.1
XP_013379234.1, XM_013523780.1
XP_013379235.1, XM_013523781.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsemblMetazoaig21979.t1; g21979.t1; g21979
GeneIDi106150791
KEGGilak:106150791

Phylogenomic databases

OMAiIQKFQWR
OrthoDBi422699at2759

Family and domain databases

CDDicd06461, M2_ACE, 1 hit
InterProiView protein in InterPro
IPR001548, Peptidase_M2
PANTHERiPTHR10514, PTHR10514, 1 hit
PfamiView protein in Pfam
PF01401, Peptidase_M2, 1 hit
PRINTSiPR00791, PEPDIPTASEA

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1S3GZX9_LINUN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1S3GZX9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: February 10, 2021
This is version 18 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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