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Protein

Claudin

Gene

Cldn4

Organism
Dipodomys ordii (Ord's kangaroo rat)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
ClaudinUniRule annotation
Gene namesi
Name:Cldn4Imported
OrganismiDipodomys ordii (Ord's kangaroo rat)Imported
Taxonomic identifieri10020 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaCastorimorphaHeteromyidaeDipodomyinaeDipodomys
Proteomesi
  • UP000081671 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei79 – 97HelicalUniRule annotationAdd BLAST19
Transmembranei117 – 140HelicalUniRule annotationAdd BLAST24
Transmembranei160 – 183HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Cell junction, Cell membraneUniRule annotationSAAS annotation, Membrane, Tight junctionUniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003550 Claudin4
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01379 CLAUDIN4
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1S3GIM8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASMGLQMLG IALAVLGWLG AILSCALPMW RVTAFIGSNI VTAQTSWEGL
60 70 80 90 100
WMNCVVQSTG QMQCKVYDSL LALPQDLQAA RALIVISIIV AALALLLSIV
110 120 130 140 150
GGKCTNCVED ETTKAKIMIV SGVVFLLACL LVIVPISWTA HNIIRDFYNP
160 170 180 190 200
LVASGQKREM GASLYIGWAA SGLLLLGGAL LCCSCPPRQD KPYSAKYSAA

RSAPASNYV
Length:209
Mass (Da):22,197
Last modified:April 12, 2017 - v1
Checksum:iDE98BE426B88AC71
GO

Sequence databases

RefSeqiXP_012888646.1, XM_013033192.1

Genome annotation databases

EnsembliENSDORT00000007736; ENSDORP00000023155; ENSDORG00000007737
GeneIDi105998477

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_012888646.1, XM_013033192.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDORT00000007736; ENSDORP00000023155; ENSDORG00000007737
GeneIDi105998477

Organism-specific databases

CTDi1364

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003550 Claudin4
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01379 CLAUDIN4
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A1S3GIM8_DIPOR
AccessioniPrimary (citable) accession number: A0A1S3GIM8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: June 20, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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