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Entry version 13 (05 Jun 2019)
Sequence version 1 (12 Apr 2017)
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Protein

Sodium channel protein

Gene

Scn9a

Organism
Dipodomys ordii (Ord's kangaroo rat)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Scn9aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDipodomys ordii (Ord's kangaroo rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10020 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaCastorimorphaHeteromyidaeDipodomyinaeDipodomys
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000081671 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei120 – 143HelicalUniRule annotationAdd BLAST24
Transmembranei188 – 207HelicalUniRule annotationAdd BLAST20
Transmembranei219 – 240HelicalUniRule annotationAdd BLAST22
Transmembranei246 – 266HelicalUniRule annotationAdd BLAST21
Transmembranei382 – 409HelicalUniRule annotationAdd BLAST28
Transmembranei741 – 767HelicalUniRule annotationAdd BLAST27
Transmembranei779 – 802HelicalUniRule annotationAdd BLAST24
Transmembranei814 – 838HelicalUniRule annotationAdd BLAST25
Transmembranei859 – 887HelicalUniRule annotationAdd BLAST29
Transmembranei949 – 972HelicalUniRule annotationAdd BLAST24
Transmembranei1197 – 1215HelicalUniRule annotationAdd BLAST19
Transmembranei1236 – 1252HelicalUniRule annotationAdd BLAST17
Transmembranei1264 – 1284HelicalUniRule annotationAdd BLAST21
Transmembranei1313 – 1339HelicalUniRule annotationAdd BLAST27
Transmembranei1438 – 1461HelicalUniRule annotationAdd BLAST24
Transmembranei1520 – 1538HelicalUniRule annotationAdd BLAST19
Transmembranei1550 – 1568HelicalUniRule annotationAdd BLAST19
Transmembranei1580 – 1600HelicalUniRule annotationAdd BLAST21
Transmembranei1637 – 1665HelicalUniRule annotationAdd BLAST29
Transmembranei1741 – 1764HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini123 – 415Ion_transInterPro annotationAdd BLAST293
Domaini488 – 698Na_trans_cytoplInterPro annotationAdd BLAST211
Domaini749 – 977Ion_transInterPro annotationAdd BLAST229
Domaini986 – 1191Na_trans_assocInterPro annotationAdd BLAST206
Domaini1195 – 1470Ion_transInterPro annotationAdd BLAST276
Domaini1519 – 1774Ion_transInterPro annotationAdd BLAST256

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni24 – 53DisorderedSequence analysisAdd BLAST30
Regioni465 – 547DisorderedSequence analysisAdd BLAST83
Regioni1094 – 1153DisorderedSequence analysisAdd BLAST60
Regioni1942 – 2007DisorderedSequence analysisAdd BLAST66

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili406 – 444Sequence analysisAdd BLAST39
Coiled coili690 – 710Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi24 – 49PolyampholyteSequence analysisAdd BLAST26
Compositional biasi490 – 533PolyampholyteSequence analysisAdd BLAST44
Compositional biasi1113 – 1128PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1942 – 1963PolarSequence analysisAdd BLAST22
Compositional biasi1965 – 1988PolyampholyteSequence analysisAdd BLAST24
Compositional biasi1989 – 2007PolarSequence analysisAdd BLAST19

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
56920at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005821 Ion_trans_dom
IPR000048 IQ_motif_EF-hand-BS
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR024583 Na_trans_cytopl
IPR028803 SCN9A
IPR027359 Volt_channel_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10037:SF221 PTHR10037:SF221, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PF11933 Na_trans_cytopl, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00170 NACHANNEL

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00015 IQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1S3G1R5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPPPGPQSF VRFTKQSLAL IEQRIAEERA KEPKEEKKDD EEEAPKPSSD
60 70 80 90 100
LEAGKQLPFI YGDIPPGMVS LPLEDLDPYY ANKKTFIVLN KGKAIFRFNA
110 120 130 140 150
TPALYMLSPF NPLRRISIKI LVHSLFSMLI MCTILTNCIF MTMSNPLEWT
160 170 180 190 200
KNVEYTFTGI YTFESLVKIL ARGFCVGEFT FLRDPWNWLD FVVIVFAYVT
210 220 230 240 250
EFVDLGNVSA LRTFRVLRAL KTISVIPGLK TIVGALIQSV KKLSDVMILT
260 270 280 290 300
VFCLSVFALI GLQLFMGNLK HKCFRNNLEN NETLESILNR TESEDELRSF
310 320 330 340 350
IQPEKYFYYL EGSKDALLCG FSTDSGQCPE GYSCVKAGRN PDYGYTSFDT
360 370 380 390 400
FSWAFLALFR LMTQDYWENL YQQTLRAAGK TYMIFFVVVI FLGSFYLINL
410 420 430 440 450
ILAVVAMAYE EQNQANIEEA KQKEIEFQQM LDRLKKEQEE AEAIAVAAAE
460 470 480 490 500
YTSIGRSRIM GLSESSSETS KLSSKSAKER RNRRKKKNQK KLSSGEEKGD
510 520 530 540 550
EEKLSKSGSE ESIRRKSFHL GVESHKRARE KRLSTPNQSP LSIPGSLFSA
560 570 580 590 600
RRSSRTSLFS FKGRGKEIGS ETEFADDEHS IFGDNESRRG SLFVPHRPWE
610 620 630 640 650
RRSSNISQAS RSPPMLPVNG KMHSAVDCNG VVSLVDGPSA LMLPNGQLLP
660 670 680 690 700
EVIIDKATSD ESGTSNQIRK KRRSSSYFLS EDMLNDPHLR QRAMSRASIL
710 720 730 740 750
TNTVEELEES RQKCPPWWYR FAHTFLIWNC SPYWIKFKKF IYFIVMDPFV
760 770 780 790 800
DLAITICIVL NTLFMAMEHH PMTEEFKNVL TVGNLVFTGI FAAEMVLKLI
810 820 830 840 850
AMDPYEYFQV GWNIFDSIIV TLSLVELFLS DVEGLSVLRS FRLLRVFKLA
860 870 880 890 900
KSWPTLNMLI KIIGNSVGAL GNLTLVLAII VFIFAVVGMQ LFGKSYKECV
910 920 930 940 950
CKINEDCTLP RWHMNDFFHS FLIVFRVLCG EWIETMWDCM EVAGQTMCLI
960 970 980 990 1000
VYMMVMVIGN LVVLNLFLAL LLSSFSSDNL TAIEEDTDAN NLQIAVARIK
1010 1020 1030 1040 1050
RGINYVKQTL REFILKAFSK KPKISKEIIR AENLNNKKEN YISNRTLAEM
1060 1070 1080 1090 1100
SKDYHFHNEK ERLSGYGSSM DKTLMEESDY QSFIHNPSLT VTVPIAPGES
1110 1120 1130 1140 1150
DLENMNTEEL SSDSDSDYSK ERRNRSSSSE CSTVDNPLPG EGEEAEAEPV
1160 1170 1180 1190 1200
NSDEPEACFT DGCVRRFPCC QVNIDSGKGK IWWNIRKTCY RIVEHSWFES
1210 1220 1230 1240 1250
FIVLMILLSS GALAFEDIYI EKKKTIRTIL EYADKIFTYI FILEMLLKWV
1260 1270 1280 1290 1300
AYGYKTYFTN AWCWLDFLIV DVSLVTLVAS TLGYSDLGPI KSLRTLRALR
1310 1320 1330 1340 1350
PLRALSRFEG MRVVVNALIG AIPSIMNVLL VCLIFWLIFS IMGVNLFAGK
1360 1370 1380 1390 1400
FYECVNTTDG TRFSTSQVEN RSECFALMNG SANVRWKNLK VNFDNVGLGY
1410 1420 1430 1440 1450
LSLLQVATFK GWMDIMYAAV DSVDVDEQPK YEYNLYMYIY FVIFIIFGSF
1460 1470 1480 1490 1500
FTLNLFIGVI IDNFNQQKKK LGGQDIFMTE EQKKYYNAMK KLGSKKPQKP
1510 1520 1530 1540 1550
IPRPGNKFQG CIFDLVTNQA FDITIMVLIC LNMVTMMVEK EGQSENMTIV
1560 1570 1580 1590 1600
LYWINLVFII LFTGECVLKL ISLRHYYFTV GWNIFDFVVV ILSIVGMFLA
1610 1620 1630 1640 1650
DLIEKYFVSP TLFRVIRLAR IGRILRLIKG AKGIRTLLFA LMMSLPALFN
1660 1670 1680 1690 1700
IGLLLFLVMF IYAIFGMSNF AYVKKEAGIN DMFNFETFGN SMICLFQITT
1710 1720 1730 1740 1750
SAGWDGLLAP ILNSAPPDCD PKKVHPGSSV EGDCGNPSVG IFYFVSYIII
1760 1770 1780 1790 1800
SFLVVVNMYI AVILENFSVA TEESTEPLSE DDFERFYEIW EKFDPDATQF
1810 1820 1830 1840 1850
IEYSKLSDFA AALDPPLLIA KPNKVQLIAM DLPMVSGDRI HCLDILFAFT
1860 1870 1880 1890 1900
KRVLGESGEM DSLRSQMEER FMSANPSKVS YEPITTTLKR KQEDVSATVI
1910 1920 1930 1940 1950
QRSYRRYRLR KNVKNISSIY IKDGDKDDNL PNKEDIVFAN VNENSSPEKT
1960 1970 1980 1990 2000
DATPSTISPP SYDSVTKPDK EKYETDKTEK EDKQEQGNAQ EAIRVSPDNT
2010 2020 2030
KSRIGTNNDG VAVSLLLEMC GACATFVSSW STMKST
Length:2,036
Mass (Da):231,681
Last modified:April 12, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i327302E08D47D4D0
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_012882748.1, XM_013027294.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
105993911

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_012882748.1, XM_013027294.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi105993911

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6335

Phylogenomic databases

OrthoDBi56920at2759

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR000048 IQ_motif_EF-hand-BS
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR024583 Na_trans_cytopl
IPR028803 SCN9A
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037:SF221 PTHR10037:SF221, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PF11933 Na_trans_cytopl, 1 hit
PRINTSiPR00170 NACHANNEL
SMARTiView protein in SMART
SM00015 IQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1S3G1R5_DIPOR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1S3G1R5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: June 5, 2019
This is version 13 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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