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Protein
Submitted name:

dedicator of cytokinesis protein 10 isoform X1

Gene

Dock10

Organism
Dipodomys ordii (Ord's kangaroo rat)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
dedicator of cytokinesis protein 10 isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dock10Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDipodomys ordii (Ord's kangaroo rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10020 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaCastorimorphaHeteromyidaeDipodomyinaeDipodomys
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000081671 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini168 – 277PHInterPro annotationAdd BLAST110
Domaini659 – 837DHR-1InterPro annotationAdd BLAST179
Domaini1677 – 2137DHR-2InterPro annotationAdd BLAST461

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08697 C2_Dock-D, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR037809 C2_Dock-D
IPR035892 C2_domain_sf
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR010703 DOCK_C
IPR021816 DOCK_C/D_N
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

The PANTHER Classification System

More...
PANTHERi
PTHR23317 PTHR23317, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PF11878 DUF3398, 1 hit
PF00169 PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51650 DHR_1, 1 hit
PS51651 DHR_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A1S3EKM4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFRGKEFWK KRRTVRRVNP EEIHRFSSQE KPRLLEPLDY EAVIEELEKT
60 70 80 90 100
YGNDPLQDLL FFPKDDFSTA TVSWDIRTLY STVPEDAEHR AENLLVKEAC
110 120 130 140 150
KFYSSQWYVV NYKYERYSGD IRHLPRAEYK AEKLPSHSFE VDHEDADKDE
160 170 180 190 200
DTTSHSSSKG GGGAGGTGVF KSGWLYKGNF NSTVNNTVTV RSFKKRYFQL
210 220 230 240 250
TQLPDSSYIM NFYKDEKISK EPKGCIFLDS CTGVVQNNRL RKYAFELKMH
260 270 280 290 300
DLTYFVLAAE TESDMDEWIH TLNRILQISP EGPMQGRRST ELADLGLDPL
310 320 330 340 350
HNSVTCECTL EETDSSENSL HPDFAKYLTE TEDSVKTTRN MERLNLFLLD
360 370 380 390 400
PDIDTLKLQK KDVLEPEFVI KPFEEKAAKR IMIICKALNF NLQGCVTENE
410 420 430 440 450
SDPITNIEPF FVSVALYDLR DGRKISADFH VDLNHTVVRQ MLLGPPMALE
460 470 480 490 500
NGTIDTITPR QSEEPHIKGL PEEWLKFPKQ AIFSVSDPHS EIVLVAKIEK
510 520 530 540 550
VLMGNIASGA EPYIKNPDSN KFAQKILKSN RHFCSKLGKY RMPFAWAVRS
560 570 580 590 600
VFKDNQGNVD RDSRFSPLYR QESSKISTED LLKLVSDYRR ADRISKMQTI
610 620 630 640 650
PGSLDIAVDN IPLEHPNCVT SSFIPVKPFN LMAQSEPTVE VEEFIYDSTK
660 670 680 690 700
HCRPYRVYKN QIYIYPRHLK YDSQKCFNKA RNITVCIEFK NSDEEGAKPV
710 720 730 740 750
KCIYGKPGGP LFTSAAYTAV LHHSQNPDFS DEVKIELPTQ LHEKHHILFS
760 770 780 790 800
FYHVTCDINA KANAKKKEAL ETSVGYAWLP LMKHCQIASQ DYHIPVATIL
810 820 830 840 850
PPHYLSIQDS ASGKHGGNDV KWVDGGKPLF KVSTFVVSTV NTQDPHVNAF
860 870 880 890 900
FQQCQKREKD MSQSPTSSFI RSCKNLLNVE KIHAIMSFLP IILNQLFKVL
910 920 930 940 950
VQNEEDEIST TVTRVLTDIV AKCHEEQLDH SVQSYIKFVF KTRTYKERTI
960 970 980 990 1000
HEELAKNVTG LLKSNDSTTV KHVLKHSWFF FAIILKSMAQ HLIDTNKIQL
1010 1020 1030 1040 1050
SRAQRFPESY QNELDNLVML VCDHVIWKYR DTLEETKRAN QSVARFLKRC
1060 1070 1080 1090 1100
FTFMDRGFVF RMVNNYVSMF SSGELKTLCQ YKFDFLQEVC QHEHFIPLCL
1110 1120 1130 1140 1150
PIRSAYIPDP VTPSESIQEL HASDMPEYSV TNEFCRKHFL IGILLREVGF
1160 1170 1180 1190 1200
ALQEDQDVRH LALAVLKNLM AKHSFDDRYR EPRKQAQIAS LYMPLYGMLL
1210 1220 1230 1240 1250
DNMPRIYLKD LYPFTINTSN QGSRDDLSTN GGFQTQTSMK HATSVDTSFS
1260 1270 1280 1290 1300
KDVLNSIAAF SSIAISTVNH ADSRASLASL DSNPSTNEKS SDKMDNCEKI
1310 1320 1330 1340 1350
PRPLSLIGST LRFDKLDQAE TRSLLMCFLH IMKTISDETL IAYWQRAPSP
1360 1370 1380 1390 1400
EVSDFFSILD VCLQNFRYLG KRNIIRKIAA AFKFVQSTQS NGTLKGSNPS
1410 1420 1430 1440 1450
CQTSGLLSQW MHTTSGHEGH KQHRSQTLPI IRGKNALSNP KLLQMLDNTM
1460 1470 1480 1490 1500
TSNSNEIDIV HHVDTEANIA TEVCLTILDL LTLFTQVHQR QLQQSECQNS
1510 1520 1530 1540 1550
LVKRVFDTYM LFFQVNQSAA ALKHVFASLR LFVCKFPSAF FQGPADLCGS
1560 1570 1580 1590 1600
FCYEVLKCCN HRSRSTQTEA SALLYFFMRK NFEFNKQKSI VRSHLQLIKA
1610 1620 1630 1640 1650
VSQLIADAGI GGSRFQHSLA ITNNFANGDK QMRNSNFPAE VKDLTKRIRT
1660 1670 1680 1690 1700
VLMATAQMKE HEKDPEMLVD LQYSLANSYA STPELRRTWL ESMAKIHARN
1710 1720 1730 1740 1750
GDLSEAAMCY IHIAALIAEY LKRKGYWKME KICTSSLVPE DAHPCDSHPL
1760 1770 1780 1790 1800
LTTPGGGSMF SMGWPAFVSI TPNIKEEGAM KEDSGMQDTP YNESILVEQL
1810 1820 1830 1840 1850
YMCVEFLWKS ERYELIADVN KPIIAVFEKQ RDFKKLSDLY YDIHRSYLKV
1860 1870 1880 1890 1900
AEVVNSEKRL FGRYYRVAFY GQGFFEEEEG KEYIYKEPKL TGLSEISQRL
1910 1920 1930 1940 1950
LKLYADKFGA DNVKIIQDSN KVNPKELDPK YAYIQVTYVT PFFEEKEIED
1960 1970 1980 1990 2000
RRTDFEMHHN INRFVFETPF TLSGKKHGGV AEQCKRRTIL TTSHLFPYVK
2010 2020 2030 2040 2050
KRIQVISQSS TELNPIEVAI DEMSRKVSEL NQLCTMDEVD MIRLQLKLQG
2060 2070 2080 2090 2100
SVSVKVNAGP MAYARAFLEE TNAKKYPDNQ VKLLKEIFRQ FADACGQALD
2110 2120 2130 2140 2150
VNERLIKEDQ LEYQEELRSH YKDMLSELSA VMNEQLCRGP CLYSFCSSVS
2160 2170 2180
SMSLSTVSKS DYGQGRPSKA RSGAPQHSYN
Length:2,180
Mass (Da):249,720
Last modified:April 12, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4BB84E1B8576ABB4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1S3EM27A0A1S3EM27_DIPOR
dedicator of cytokinesis protein 10...
Dock10
2,171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1S3EM17A0A1S3EM17_DIPOR
dedicator of cytokinesis protein 10...
Dock10
2,173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1S3EM07A0A1S3EM07_DIPOR
dedicator of cytokinesis protein 10...
Dock10
2,179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1S3EJK1A0A1S3EJK1_DIPOR
dedicator of cytokinesis protein 10...
Dock10
1,971Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_012864504.1, XM_013009050.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
105980285

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_012864504.1, XM_013009050.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi105980285

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55619

Family and domain databases

CDDicd08697 C2_Dock-D, 1 hit
Gene3Di2.30.29.30, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR037809 C2_Dock-D
IPR035892 C2_domain_sf
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR010703 DOCK_C
IPR021816 DOCK_C/D_N
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR23317 PTHR23317, 1 hit
PfamiView protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PF11878 DUF3398, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51650 DHR_1, 1 hit
PS51651 DHR_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1S3EKM4_DIPOR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1S3EKM4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: December 5, 2018
This is version 12 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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