Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 6 (16 Jan 2019)
Sequence version 1 (12 Apr 2017)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein
Submitted name:

tumor suppressor p53-binding protein 1

Gene

TP53BP1

Organism
Erinaceus europaeus (Western European hedgehog)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
tumor suppressor p53-binding protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TP53BP1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiErinaceus europaeus (Western European hedgehog)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9365 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraErinaceidaeErinaceinaeErinaceus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000079721 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1717 – 1841BRCTInterPro annotationAdd BLAST125
Domaini1857 – 1957BRCTInterPro annotationAdd BLAST101

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili789 – 816Sequence analysisAdd BLAST28

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
27155at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00027 BRCT, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.30, 1 hit
3.40.50.10190, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015125 53-BP1_Tudor
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR014722 Rib_L2_dom2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09038 53-BP1_Tudor, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00292 BRCT, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52113 SSF52113, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50172 BRCT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1S3ADU2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGEQMDPTG SHLDSDFSQQ DTPCLLIEDS QPESQVLDDG SGSHFSMLSR
60 70 80 90 100
HLPNLQTHKE NPGLDVVSNS EQTTGEDQGD NNSGIHEHLK ENKADPVDSS
110 120 130 140 150
PLDTCGAISQ VIEQVPQPNR TSSILTMSVE PDASVGEEKE EELEGKEEKE
160 170 180 190 200
ADTSDDAAAT HSLGVEDASS QLGFGVLELS QSQDVEEHTV PYEPNKERLQ
210 220 230 240 250
PVTADTGYAR LSDTDTETAI KHEEQSNVDI PMTALPTLPS KDVSVTALPS
260 270 280 290 300
KDVNEQDPLL ARSEDMASSP KVPLTTMETK EQTSTQELLE SSLQIQKSPE
310 320 330 340 350
PEVMSTQEDM FDQSNKTASD ACSTPSREEG GCSLASTPAT TLHLLQLSGQ
360 370 380 390 400
RSLVQESLST NSSDLVAPSP DALRSTPFIV PSSPTEQEGR TDEPMDMSVL
410 420 430 440 450
SEGGESLQKK PQPVELEDPP LPLELTVSPQ VSTPVSQSTP VFTPGSLPIP
460 470 480 490 500
SQPEFSHDIF IPSPSLEERS NDGKKGGDLH SSSLTVECSK NSEIEPKNSP
510 520 530 540 550
EDLGLSLTGD SCKLMLSTSE YSQSPKMESL SEHRIDEDGE NTQIEDTEPM
560 570 580 590 600
SPVLNSKLIP AENDNILMTP AQDVQVELIH NDDKAKEDDT ETRDDSSILT
610 620 630 640 650
TDCKGREETA AEDVCIDLTC DSGSQAVPSP ATRSEALSSV LDQEEAMDIK
660 670 680 690 700
EQHSIGSDVE EIPETPCESQ GEESKENMET VPLHLPLTET QSQGLCLSKE
710 720 730 740 750
APKQECQEAM EVETSVISID SPQKLPVLDQ ELEHKDQEAW EEATSEDSSV
760 770 780 790 800
VIVDVKEPSP RVDISSEPLE AVEKCSDSQS WEDDVPEIER CAENRADNQE
810 820 830 840 850
QKSAEYEGNL KSVDAEKEPI EADSPQPPLT LVRADDALRS NQEMQLTQAQ
860 870 880 890 900
EEKSVTGDSK ITNAKQLGSS VDAQPLEKAP VHASQSFCES SSETPFHFTL
910 920 930 940 950
PKEGDIISPL TGATPPLIGH LKLEPKRHST PIDISSYPER AIAASDVMSE
960 970 980 990 1000
SMMETNDPIL ENEKGGSGAP LETDDKLSLR MKLVSPETEA SEESLQFNLE
1010 1020 1030 1040 1050
KPAIGERKNG SATVAEAVAS PQKTISVLSC VHETFETQPE NDTRNQDSPS
1060 1070 1080 1090 1100
APIRGNFRLF ASTPEKEKEK LEGDQRTSQR QQSVTPSRPV KDPDFPASQQ
1110 1120 1130 1140 1150
MTTQRPSSPQ GEKMKIDVFL DQKEIENSNQ DKSSKSIIER PSQNNIGIQT
1160 1170 1180 1190 1200
IEHSLRVTET ASAATQTVKN VCEQGTSTVE QNSGKQDATV QTERRSAEKP
1210 1220 1230 1240 1250
ASAPGDDTES LHSQAEEEFE MPQPPHGHVL HRHMRTIREV RTLVTRVITD
1260 1270 1280 1290 1300
VYYVDGTEVE RKVTEETEEP IVECQECETE VSPSQTGGSS GDLGDISSFS
1310 1320 1330 1340 1350
SKASSFHRTS SGTSLSAIHS SGSSGRGAGP LKGKASGTDP ADFALPSSRG
1360 1370 1380 1390 1400
GPGKLSPRKG VSQTGAPLCE EDGDAGLAIR QGGKAPVTPR GRGRRGRPPS
1410 1420 1430 1440 1450
RTTGTRETAV PGPLGIEDIS PSMSPDDKSF TRVVPRVPDS TKRADVGAGA
1460 1470 1480 1490 1500
LRRSDSPEIP FQAAAGSSDG LDTSSPGNSF VGLRVVAKWS SNGYFYSGKI
1510 1520 1530 1540 1550
TRDVGAGKYK LLFDDGYECD VLGKDILLCD PIPLDTEVTA LSEDEYFSAG
1560 1570 1580 1590 1600
VVKGHRKESG ELYYSIEKEG QRKWYKRMAV ILSLEQGNRL REQYGLGPYE
1610 1620 1630 1640 1650
AVTPLTKAAD ISLDNLVEGK RKRRSNISSP ATPTVSSSSS TTPTRKITES
1660 1670 1680 1690 1700
PRATGVPSGK RKLTVSEEER SPAKRGRKST TVKPGAVGAG EFVSPCESGD
1710 1720 1730 1740 1750
NMGDAATLEE QRGPLPLNKT LFLGYAFLLT MATTSDKLAS RSKLLDGPTG
1760 1770 1780 1790 1800
SSEEEEEILE IPPFNKQYTE SQLRAGAGYI LEDFNEAQCN TAYQCLLIAD
1810 1820 1830 1840 1850
QHCRTRKYFL CLASGIPCVS HVWVHDSCHA NQLQNYRNYL LPAGYSLEEQ
1860 1870 1880 1890 1900
RILDWQPREN PFQNLKVLLV SDQQQNFLEL WSEILMTGGA ASVKQHHSSA
1910 1920 1930 1940 1950
HNKDIALGVF DVVVTDPSCP ASVLKCAEAL QLPVVSQEWV IQCLIVGERI
1960
GFKQHPKYKH DYVSH
Length:1,965
Mass (Da):213,446
Last modified:April 12, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4118B5112AEBA70D
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_007533528.1, XM_007533466.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
103122842

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_007533528.1, XM_007533466.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi103122842

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7158

Phylogenomic databases

OrthoDBi27155at2759

Family and domain databases

CDDicd00027 BRCT, 2 hits
Gene3Di2.30.30.30, 1 hit
3.40.50.10190, 2 hits
InterProiView protein in InterPro
IPR015125 53-BP1_Tudor
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR014722 Rib_L2_dom2
PfamiView protein in Pfam
PF09038 53-BP1_Tudor, 1 hit
SMARTiView protein in SMART
SM00292 BRCT, 2 hits
SUPFAMiSSF52113 SSF52113, 2 hits
PROSITEiView protein in PROSITE
PS50172 BRCT, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1S3ADU2_ERIEU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1S3ADU2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: January 16, 2019
This is version 6 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again