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Protein

Protein disulfide-isomerase A4

Gene

PDIA4

Organism
Erinaceus europaeus (Western European hedgehog)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationImported

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase A4UniRule annotation (EC:5.3.4.1UniRule annotation)
Alternative name(s):
Endoplasmic reticulum resident protein 72UniRule annotation
Gene namesi
Name:PDIA4Imported
OrganismiErinaceus europaeus (Western European hedgehog)Imported
Taxonomic identifieri9365 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraErinaceidaeErinaceinaeErinaceus
Proteomesi
  • UP000079721 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24UniRule annotationAdd BLAST24
ChainiPRO_501000414525 – 640Protein disulfide-isomerase A4UniRule annotationAdd BLAST616

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi201 ↔ 204Redox-activeUniRule annotation
Disulfide bondi550 ↔ 553Redox-activeUniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 164ThioredoxinInterPro annotationAdd BLAST147
Domaini166 – 296ThioredoxinInterPro annotationAdd BLAST131
Domaini500 – 631ThioredoxinInterPro annotationAdd BLAST132

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili37 – 57Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Redox-active centerUniRule annotationSAAS annotation, RepeatSAAS annotation, SignalUniRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR005788 Disulphide_isomerase
IPR005792 Prot_disulphide_isomerase
IPR017068 Protein_diS-isomerase_A4
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 3 hits
PIRSFiPIRSF036862 Disulphide_isom_A4, 1 hit
SUPFAMiSSF52833 SSF52833, 5 hits
TIGRFAMsiTIGR01130 ER_PDI_fam, 1 hit
TIGR01126 pdi_dom, 3 hits
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 3 hits
PS51352 THIOREDOXIN_2, 3 hits

Sequencei

Sequence statusi: Complete.

A0A1S3AC67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPRKACLLL LLLALTQLLA ATNARDPDED PSKEDTVEED EEDEDEEEDD
60 70 80 90 100
LEVSEENGVL VLKDSNFDTF VADKDTVLLE FYAPWCGHCK QFAPEYEKIA
110 120 130 140 150
STLKEHEPPI PVAKIDATAE TSLASRFDVS GYPTIKILKK GQAVDYEGAR
160 170 180 190 200
SHEEIVAKVK EVFQPNWTPP PEATLVLTKD NFDEVVNTAD IMLVEFYAPW
210 220 230 240 250
CGHCKKLAPE YEKAAKELSK RSPAIPLAKV DATAETELAT RFEVSGYPTL
260 270 280 290 300
KIFRRGKPFE YNGPREKYGI VDYMLEQSGP PSKEVAGLKQ VQETLKDGDD
310 320 330 340 350
VIVIGVFRGD SDPAYQRYLD AANSLREDYK LQHTFSTEVA RFLKAAPGQL
360 370 380 390 400
VVTQPEKFQS KFESRSHLLD IQASTEPAAI REHVQQHTLP LVGHRKPAND
410 420 430 440 450
NKRYARRPLV VVYYSVDFSF DYRVATQFWR HKVLEVAKDF PEYTFAVADE
460 470 480 490 500
DDFASEVRDL GLSESGEDVN AAILDEGGRR FAMEPDDFDA NALRDFVTAF
510 520 530 540 550
KKGKLQPVIK SQPVPKNNKG PVKVVVGKTF DAVVMDAKKD VLIEFYAPWC
560 570 580 590 600
GHCKQLEPVY TELAKKYKAH KGLVIAKMDA TANDVPHPGY KVEGFPTIYL
610 620 630 640
APRGDKEHPV KFEEGGRDLE QLSKFLEEHA RSLGRTREEL
Length:640
Mass (Da):72,084
Last modified:April 12, 2017 - v1
Checksum:iB0E2DFADBB960490
GO

Sequence databases

RefSeqiXP_007532784.1, XM_007532722.1

Genome annotation databases

GeneIDi103122127

Similar proteinsi

Entry informationi

Entry nameiA0A1S3AC67_ERIEU
AccessioniPrimary (citable) accession number: A0A1S3AC67
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: July 18, 2018
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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