Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 9 (16 Jan 2019)
Sequence version 1 (12 Apr 2017)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein
Submitted name:

protocadherin-16

Gene

DCHS1

Organism
Erinaceus europaeus (Western European hedgehog)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalciumSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
protocadherin-16Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DCHS1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiErinaceus europaeus (Western European hedgehog)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9365 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraErinaceidaeErinaceinaeErinaceus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000079721 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2663 – 2689HelicalSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 40Sequence analysisAdd BLAST40
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501022993041 – 3026Sequence analysisAdd BLAST2986

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini62 – 139CAInterPro annotationAdd BLAST78
Domaini163 – 251CAInterPro annotationAdd BLAST89
Domaini275 – 358CAInterPro annotationAdd BLAST84
Domaini386 – 468CAInterPro annotationAdd BLAST83
Domaini493 – 574CAInterPro annotationAdd BLAST82
Domaini598 – 681CAInterPro annotationAdd BLAST84
Domaini705 – 786CAInterPro annotationAdd BLAST82
Domaini810 – 890CAInterPro annotationAdd BLAST81
Domaini914 – 992CAInterPro annotationAdd BLAST79
Domaini1020 – 1098CAInterPro annotationAdd BLAST79
Domaini1122 – 1204CAInterPro annotationAdd BLAST83
Domaini1234 – 1311CAInterPro annotationAdd BLAST78
Domaini1313 – 1375CAInterPro annotationAdd BLAST63
Domaini1399 – 1477CAInterPro annotationAdd BLAST79
Domaini1500 – 1581CAInterPro annotationAdd BLAST82
Domaini1605 – 1686CAInterPro annotationAdd BLAST82
Domaini1714 – 1794CAInterPro annotationAdd BLAST81
Domaini1818 – 1897CAInterPro annotationAdd BLAST80
Domaini1921 – 2003CAInterPro annotationAdd BLAST83
Domaini2026 – 2102CAInterPro annotationAdd BLAST77
Domaini2126 – 2208CAInterPro annotationAdd BLAST83
Domaini2232 – 2328CAInterPro annotationAdd BLAST97
Domaini2352 – 2432CAInterPro annotationAdd BLAST81
Domaini2456 – 2539CAInterPro annotationAdd BLAST84
Domaini2563 – 2654CAInterPro annotationAdd BLAST92

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
34489at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028 Cadherin, 23 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 25 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 25 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1S3A1G8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQKEPGVASS CAAGMLSPRP LPVLPLLLLL LGVGMPGAWG KAGSLDLQID
60 70 80 90 100
EEQPAGTVIG DISAGLPAGT LPPPMYFISA QEGSGVGTDL AIDEHSGVVR
110 120 130 140 150
TARVLDRERR DHYRFTAVTP DGTTVEVTVR VVDINDHVPA FPKAQATLQI
160 170 180 190 200
PEHTALGTRY PLEPAQDADA GRLGTQGYAL SGDGAGETFR LETRPGPDGT
210 220 230 240 250
PVPELVVAGE LDRENRSHYM LQLEAYDGGS PPRRAQALLD VSLLDINDHA
260 270 280 290 300
PTFNQSRYHA VVSESLPPGS PVVQLYASDA DAGANGAVTY EINRRQSEGD
310 320 330 340 350
GPFSIDAHTG LLRLERPLDF EQRRVHELVV QARDSGAHPE LGSAFVTVHV
360 370 380 390 400
RDANDNQPSM TVIFLSADGS PRVSEAAPPG QLVARISVSD PDDGDFAHVN
410 420 430 440 450
VSLEGGEGHF ALSTQDSVIY LVCVARRLDR EERDAYNLRV TATDSGSPPL
460 470 480 490 500
RAEAAFVLHV TDVNDNAPAF DRQLYRPEPL PEVALPGSFV VRVVARDPDQ
510 520 530 540 550
GTNGQVTYSL APSAHTRWFS IDPTSGIITT AGSLDYEVEP QPQLIVVATD
560 570 580 590 600
GGVPPLTSST TVSVALQDVN DNEPQFQKTF YNASLLESTL PGTCFLQVTA
610 620 630 640 650
TDEDSGPFGL LSYSLGAGLG SSGSPPFRID AQSGDVCTTR TLDHDQGPSS
660 670 680 690 700
FDFTVTAVDG GGLKSMVYVK VFVSDENDNP PYFYPREYAA SLSAQSTPGT
710 720 730 740 750
AVLRVCAHDP DQGSHGRLSY HILAGNSPPL FALDEHSGLL TVAWPLARRA
760 770 780 790 800
NSVVQLEIGA QDGGGLQAEP SARVNISIVP GTPTPPIFEQ LQYVFSVPED
810 820 830 840 850
VAPGTSVGTV QAHNPPGRLG PVTLALSGGD PRGLFSIDGA SGLLQTLRPL
860 870 880 890 900
DRELLGPVLE LEVRAGSGVP PAFTVARVRV LLDDVNDNSP AFPAPEDTVL
910 920 930 940 950
LPPSTAPGTL IYTLRALDAD SGINSRVTFT LLSGGDGAFT VDPSAGFIRL
960 970 980 990 1000
IGPLSPPGES AYELELQAQD GGSPPRTSNF RLRVVVQDLG APGLAPHFSS
1010 1020 1030 1040 1050
PIYRVDLPSG TIPGTQVLQV QARAPDGGPV TYHLAADGSS SPFGLEPQSG
1060 1070 1080 1090 1100
WLWVRAALEQ ELYTLKVMAV SSSKAELGQQ TGTATVRVSI LSQNEHSPRL
1110 1120 1130 1140 1150
SEEPTFLAVA ENQPPGTSVG RVFATDRDSG SNGRLTYSLR QLSKDIKAFH
1160 1170 1180 1190 1200
IHPQTGEVTT LQSLDRERQS SYQLLVLVQD GGSPPRSATG TVHIAVLDLN
1210 1220 1230 1240 1250
DHSPTFLQVS GAASGGLTIQ VPDRAPPGTL VTTLQAKDPD EGENGTVLYT
1260 1270 1280 1290 1300
LTGPGAELFS LHPHSGELLT AAPLIRAERP HYSLSLSAHD QGTPPRSSSL
1310 1320 1330 1340 1350
QLLVQVGRAF PAAGRCDGSP PRSAMTGALS VVRPLDREQR AEHLLTVVAS
1360 1370 1380 1390 1400
DHGSPPRSAT QLLTVSVADV NDEAPAFQQQ EYSVLLRENS PPGTSLLTLQ
1410 1420 1430 1440 1450
ATDADLGASG QVTYGGVTGE SFSLDPDTGV LTTLQALDRE EQEEINLTVY
1460 1470 1480 1490 1500
ARDRGSPPLL THVTVRVAVE DENDHTPTFG STHLSLEVPE GQDPQTLTTL
1510 1520 1530 1540 1550
RASDPDVGAN GQLQYRILDG DPSGAFVLDL VSGEFGTMRP LDREVEPAFQ
1560 1570 1580 1590 1600
LQIEARDGGQ PALSATLLVT VAVLDANDHA PAFPVPAYSV EVPEDVPAGT
1610 1620 1630 1640 1650
LLLQLQAHDP DAGANGRVTY YLGAGAGGAF LLEPSSGELR TATVLDREQC
1660 1670 1680 1690 1700
PSYAFPVSAV DGAAAGPLSS TVPVTITVRD VNDNAPIFPT SPLRLRLPRT
1710 1720 1730 1740 1750
VPSFSRPILP LATLRAEDRD AGANASILYR LAGTPPPGTT VDSYTGEIRM
1760 1770 1780 1790 1800
TRSPVALAPQ DRILFIVATD LGRPARSSTG VIIVGLQGEA ERGPRFPRTS
1810 1820 1830 1840 1850
SETVLRENAP PGTPVVSPKA VHAGGSNGPI TYSILSGNEK GTFSIQPSTG
1860 1870 1880 1890 1900
AITVHSAEGL DFEASPRLRL VLQAESAGAF AFSVLTLTLQ DANDNVPRFL
1910 1920 1930 1940 1950
QPHYVAFLPE SRPLEGPLLQ VEADDLDQGP SGHISYSLTA SQPARGLFHV
1960 1970 1980 1990 2000
DPSTGMITTT AILDREIWAE TRLVLMATDR GNPALIGSAT LTVMVIDTND
2010 2020 2030 2040 2050
NRPTIPQPWE LRVTEDALLG SEIAQVTGND VDSGPVLWYV LNPSGPQDPF
2060 2070 2080 2090 2100
SIGRYGGRLS LTGPLDFEQH DRYELQLLAH DGPHQGHANL TVLVEDVNDN
2110 2120 2130 2140 2150
APIFSQSLYQ VTLLEHTPPG SAILSVSATD RDSGANGHIS YHLASPVEGF
2160 2170 2180 2190 2200
SVDPNNGTLF TTMDAEALSQ EGPGVVDVVL EARDQGIPGR AARATVHVQL
2210 2220 2230 2240 2250
QDQNDHAPSF TLPHYRVSVA EDLPPGSTLL TLEATDADGS RTHATVDYSI
2260 2270 2280 2290 2300
VSGNRGRVFH LEPRLAEAGE GDGLGPRALG CLVLLEPLDF EILTQYNLTV
2310 2320 2330 2340 2350
AAADRGQPPR SSAVPVTVTV LDVNDNPPVF TQAAYHVVIP EDTPVGAELL
2360 2370 2380 2390 2400
HVEASDADLD PHGLIHFTLS SGDPAGLFEL NESSGALRLV RPLDCETQAR
2410 2420 2430 2440 2450
HRLVVQAADP AGAHFTLAPV TIEVQDVNDH GPAFPLSLLS TSLAENQPPG
2460 2470 2480 2490 2500
TLVTTLHAID RDAGAFGRLR YSLLEAGLGP DGREAFALNS STGELRARVS
2510 2520 2530 2540 2550
FDYEHTGSFQ LLVGAADAGN LSASVTVSVL VIGEDEYDPV FLAPAFHFQV
2560 2570 2580 2590 2600
PEGARRGHSL GHVQATDEDS GADGLVLYSL ATSSPYFGIN QTTGAIYLRV
2610 2620 2630 2640 2650
DSQAPGSGTG TSEGGGRTRR EAPRELKLEV VARGPLPGSR SATVPVTVDI
2660 2670 2680 2690 2700
THTALGLAPD LNLLLVGAVA ASLGVVVVLA LAALVLGLVR ARSPKAEAAP
2710 2720 2730 2740 2750
GPMSQAAPLA SGTLQKLGRE PPSPPPSEHL YHQTLPSYGG PGAGGPYPRG
2760 2770 2780 2790 2800
GSLDPSHSSG RGSAEAAEDD EIRMINEFPR VASVASSLTA RGPDSGIQQD
2810 2820 2830 2840 2850
ADGLSDTSCE PPAPDTWYKG RKTGLLLPGA GATLYREEGP PATATAFLGG
2860 2870 2880 2890 2900
CGLSPAPAGD YGFPADGKPC VAGALTAIVA GEEELRGSYN WDYLLSWCPQ
2910 2920 2930 2940 2950
FQPLASVFTE IARLKDEARP CPPAPRIDPP PLITAVAHPG AKSVPPKPAS
2960 2970 2980 2990 3000
TAITRAIFPP ASHRSPISHE GSLSSAAMSP SFSPSLSPLA ARSPVVSPFG
3010 3020
VAQGPSASAL SAESGLEPPD DTELHI
Length:3,026
Mass (Da):318,243
Last modified:April 12, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA874A94CF323A56A
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_007527875.1, XM_007527813.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
103117703

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_007527875.1, XM_007527813.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi103117703

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8642

Phylogenomic databases

OrthoDBi34489at2759

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
PfamiView protein in Pfam
PF00028 Cadherin, 23 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 25 hits
SUPFAMiSSF49313 SSF49313, 25 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 12 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1S3A1G8_ERIEU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1S3A1G8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: January 16, 2019
This is version 9 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again