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Protein

Coatomer subunit gamma

Gene

COPG2

Organism
Erinaceus europaeus (Western European hedgehog)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transportUniRule annotation, Protein transportUniRule annotationSAAS annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Coatomer subunit gammaUniRule annotation
Gene namesi
Name:COPG2Imported
OrganismiErinaceus europaeus (Western European hedgehog)Imported
Taxonomic identifieri9365 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraErinaceidaeErinaceinaeErinaceus
Proteomesi
  • UP000079721 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, Cytoplasmic vesicleUniRule annotation, Golgi apparatusUniRule annotation, MembraneUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Oligomeric complex.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 538Adaptin_NInterPro annotationAdd BLAST514
Domaini612 – 758COP-gamma_platfInterPro annotationAdd BLAST147
Domaini760 – 872Coatomer_g_CplaInterPro annotationAdd BLAST113

Sequence similaritiesi

Belongs to the COPG family.UniRule annotation

Family and domain databases

Gene3Di1.25.10.10, 2 hits
2.60.40.1480, 1 hit
3.30.310.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002553 Clathrin/coatomer_adapt-like_N
IPR013041 Clathrin_app_Ig-like_sf
IPR009028 Coatomer/calthrin_app_sub_C
IPR032154 Coatomer_g_Cpla
IPR017106 Coatomer_gsu
IPR013040 Coatomer_gsu_app_Ig-like_dom
IPR037067 Coatomer_gsu_app_sf
IPR012295 TBP_dom_sf
PANTHERiPTHR10261 PTHR10261, 1 hit
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
PF16381 Coatomer_g_Cpla, 1 hit
PF08752 COP-gamma_platf, 1 hit
PIRSFiPIRSF037093 Coatomer_gamma_subunit, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF49348 SSF49348, 1 hit
SSF55711 SSF55711, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A1S2ZTD9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIKKFDKKDE ESGSGSNPFR HLEKSAVLQE ARLFNETPIN PRRCLHILTK
60 70 80 90 100
ILYLLNQGEH FGTMEATEAF FAMTRLFQSN DQTLRRMCYL TIKEMANISE
110 120 130 140 150
DVIIVTSSLT KDMTGKEDVY RGPAIRALCR ITDGTMLQAI ERYMKQAIVD
160 170 180 190 200
KVPSVSSSAL VSSLHMMKIS YDVVKRWVNE AQEAASSDNV MVQYHALGVL
210 220 230 240 250
YHLKKNDRLA VSKMLNKFTK SGLKSQFAYC MLIRIASRLL KDNEDDHENP
260 270 280 290 300
LFDFIESCLR NKNEMVIYEA ASAIIYLPNC TARELAPAVS VLQLFCSSPK
310 320 330 340 350
PALRFAAVRT LNKVAMKHPS AVIACNLDLE NLITDSNRSI ATLAITTLLK
360 370 380 390 400
TGSEASVDRL MKQISSFVSE ISDEFKVVVV QAITSLCQKY PRKHGVMMSF
410 420 430 440 450
LSNMLRDDGG FEYKRAIVDC IISVVEENPE SKEAGLAHLC EFIEDCEHTV
460 470 480 490 500
LATKILHLLG KEGPRTPAPS KYIRFIFNRV VLENEAVRAA AVSALAKFGA
510 520 530 540 550
QNESLLPSII VLLQRCMMDT DDEVRDRATF YLNVLQQRQM SLNATYICNG
560 570 580 590 600
LTVSIAGLEK ALHQYTLNPS DKPFDMKSVP LAMAPPFEQK AESKPAHVST
610 620 630 640 650
KPDKLTPSRL DIFQEQLAAI PEFVNLGPLF KSSEPVQLTE AETEYFVRCV
660 670 680 690 700
KHMFTHHIVF QFDCTNTLND QLLEKVTVQV EPSDSFEVLC YIPAPSLNYN
710 720 730 740 750
QPGICYTLVR LPDDDSAAVS GTFSCTMKFT VRDCDPDTGV PAEEGYEDEY
760 770 780 790 800
VLEDLELTLS DHIQKILKPN FAAAWEEVGD AFEKEETFAL SSTKTLDEAV
810 820 830 840 850
KNIIKFLGMQ PCERSEKVPE NKNSHSLFLA GIFRGGHDLL VRSRLALADG
860 870
VTMQVTVRSQ ERTPVDVILA SVG
Length:873
Mass (Da):97,792
Last modified:April 12, 2017 - v1
Checksum:iA9697E9B52362D06
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1S2ZTF1A0A1S2ZTF1_ERIEU
Coatomer subunit gamma
COPG2
871Annotation score:

Sequence databases

RefSeqiXP_007524271.1, XM_007524209.1

Genome annotation databases

GeneIDi103114519

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_007524271.1, XM_007524209.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi103114519

Organism-specific databases

CTDi26958

Family and domain databases

Gene3Di1.25.10.10, 2 hits
2.60.40.1480, 1 hit
3.30.310.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002553 Clathrin/coatomer_adapt-like_N
IPR013041 Clathrin_app_Ig-like_sf
IPR009028 Coatomer/calthrin_app_sub_C
IPR032154 Coatomer_g_Cpla
IPR017106 Coatomer_gsu
IPR013040 Coatomer_gsu_app_Ig-like_dom
IPR037067 Coatomer_gsu_app_sf
IPR012295 TBP_dom_sf
PANTHERiPTHR10261 PTHR10261, 1 hit
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
PF16381 Coatomer_g_Cpla, 1 hit
PF08752 COP-gamma_platf, 1 hit
PIRSFiPIRSF037093 Coatomer_gamma_subunit, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF49348 SSF49348, 1 hit
SSF55711 SSF55711, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A1S2ZTD9_ERIEU
AccessioniPrimary (citable) accession number: A0A1S2ZTD9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: February 28, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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