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UniProtKB - A0A1S2ZSG1 (A0A1S2ZSG1_ERIEU)

Entry version 16 (07 Oct 2020)
Sequence version 1 (12 Apr 2017)
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Protein
Submitted name:

proteoglycan 4 isoform X1

Gene

PRG4

Organism
Erinaceus europaeus (Western European hedgehog)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
proteoglycan 4 isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRG4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiErinaceus europaeus (Western European hedgehog)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9365 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Eulipotyphla › Erinaceidae › Erinaceinae › Erinaceus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000079721 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

SecretedARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501026991625 – 1104Sequence analysisAdd BLAST1080

Keywords - PTMi

Disulfide bondARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9365.XP_007523866.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 69SMBInterPro annotationAdd BLAST44
Domaini70 – 108SMBInterPro annotationAdd BLAST39
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati850 – 893HemopexinPROSITE-ProRule annotationAdd BLAST44
Repeati894 – 941HemopexinPROSITE-ProRule annotationAdd BLAST48

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni108 – 805DisorderedSequence analysisAdd BLAST698

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi142 – 159PolyampholyteSequence analysisAdd BLAST18
Compositional biasi160 – 181PolarSequence analysisAdd BLAST22
Compositional biasi182 – 208PolyampholyteSequence analysisAdd BLAST27
Compositional biasi277 – 297PolarSequence analysisAdd BLAST21
Compositional biasi311 – 373PolarSequence analysisAdd BLAST63
Compositional biasi374 – 392PolyampholyteSequence analysisAdd BLAST19
Compositional biasi393 – 415PolarSequence analysisAdd BLAST23
Compositional biasi416 – 507PolyampholyteSequence analysisAdd BLAST92
Compositional biasi515 – 593PolyampholyteSequence analysisAdd BLAST79
Compositional biasi616 – 649Pro-richSequence analysisAdd BLAST34
Compositional biasi665 – 681PolyampholyteSequence analysisAdd BLAST17
Compositional biasi682 – 717PolarSequence analysisAdd BLAST36
Compositional biasi725 – 752BasicSequence analysisAdd BLAST28
Compositional biasi753 – 791PolarSequence analysisAdd BLAST39

Keywords - Domaini

RepeatARBA annotation, SignalSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1565, Eukaryota

Database of Orthologous Groups

More...OrthoDBi		419397at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd00094, HX, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.110.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000585, Hemopexin-like_dom
IPR036375, Hemopexin-like_dom_sf
IPR018487, Hemopexin-like_repeat
IPR018486, Hemopexin_CS
IPR036024, Somatomedin_B-like_dom_sf
IPR020436, Somatomedin_B_chordata
IPR001212, Somatomedin_B_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00045, Hemopexin, 1 hit
PF01033, Somatomedin_B, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00022, SOMATOMEDINB

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00120, HX, 2 hits
SM00201, SO, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50923, SSF50923, 1 hit
SSF90188, SSF90188, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00024, HEMOPEXIN, 1 hit
PS51642, HEMOPEXIN_2, 2 hits
PS00524, SMB_1, 2 hits
PS50958, SMB_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A1S2ZSG1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEWKILPINL LLLLPALLIQ QVSSQDLSSC AGRCGEGYSR DATCNCDYNC 
        60         70         80         90        100
QHYMECCPDF KKVCTVELSC KGRCFESFAR GRECDCDSQC KKFGKCCPDY 
       110        120        130        140        150
DSFCEEVHNP TTPPPRKAAP PPPEASQTIR STSKRSPKSP NKKTKKVVES 
       160        170        180        190        200
EEITEEHSVS ENQESSSSSS SSSTIRKIKS SKNSAANRDL KKKPKAKDNK 
       210        220        230        240        250
KERTPEKKPT PQPPPVDDAG SGMDNVIPTP GIPVTPSRKV TTPPKVTTAK 
       260        270        280        290        300
PITPKPTVPA KPDTAKETDL TANKETTVET EETSTTNKQT STSVKKKTTS 
       310        320        330        340        350
AKETRSAEKT SADESALTSE VPTKVTPKAD STTKPSAPTT TKEPEPTTTT 
       360        370        380        390        400
NKPEPTTTTK KPEPTTTTKK PEPTTTTKKP EPTTKKPEPT TTTKKPEPTT 
       410        420        430        440        450
TTKKPEPTTT TKKPEPTTPK EPETTTTEKP EPITPKEPEP TTPKEPEPTT 
       460        470        480        490        500
PKEAEATTPK EAKPTTPKEH EPTTPKKPEP TTPKKPEPTT PKEPEPTTPK 
       510        520        530        540        550
EAEPTTPKEP EPTTPKEPTT PKKPEPTTPK KPEPTTPKKP EPTTPKKPEP 
       560        570        580        590        600
TTPKKPEPTT PKKPEPTTLK EPEPTIPKEP EPTTTKEPEP TTTKEPEPTT 
       610        620        630        640        650
PKELAPTSEK PAPNTPVAST PAPTTPKNPA EPTPELPVEP TPMGPENSPK 
       660        670        680        690        700
EPVVPTTKDS EVPKPEMTTT AKDKTTEKDK GTTPAASEIT TEEMTTTEKT 
       710        720        730        740        750
TSKPEKTTAV PKETTTESKV TPKPRKPTKA PRKPTSTKKP STKPRGRKRK 
       760        770        780        790        800
TTPAPTKMTT TAAPEPTPTS LAEDMLQTTN KPNQTPSSEM AEVNPEAEDP 
       810        820        830        840        850
DAVGDKPLTN PSSPVFTPLG VPGGNFLVIR PNQNVGADPM LSDETDLCNG 
       860        870        880        890        900
KPVDGLTTLR NGTLVAFRGH YFWMLRPFSP PSPPRKINEV WGIPSPIDTV 
       910        920        930        940        950
FTRCNCEGKT YFFKGGQYWR FTNDVRDTGY PKQIVKGFGG LNGRIVAALS 
       960        970        980        990       1000
IAKYKDRPES VYFFKRGGGI QQYTYKQEPT RKCSRSPAIN YSVYGQMTQV 
      1010       1020       1030       1040       1050
RRRRFERAIG PLTHTIRIHY SPVRVIYQDK GLLHNEVKMS TMWRGFPSVV 
      1060       1070       1080       1090       1100
TSAIALPNIR KPDSYDYYAF SKDQYYNIDI PSRTARAITT RSGQTLSKAW 

YNCP
Length:1,104
Mass (Da):121,235
Last modified:April 12, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF59EF9DCED5B7C7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1S3WC40A0A1S3WC40_ERIEU
proteoglycan 4 isoform X2
PRG4
812Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...RefSeqi		XP_007523866.1, XM_007523804.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		103114169

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_007523866.1, XM_007523804.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi9365.XP_007523866.1

Genome annotation databases

GeneIDi103114169

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10216

Phylogenomic databases

eggNOGiKOG1565, Eukaryota
OrthoDBi419397at2759

Family and domain databases

CDDicd00094, HX, 1 hit
Gene3Di2.110.10.10, 1 hit
InterProiView protein in InterPro
IPR000585, Hemopexin-like_dom
IPR036375, Hemopexin-like_dom_sf
IPR018487, Hemopexin-like_repeat
IPR018486, Hemopexin_CS
IPR036024, Somatomedin_B-like_dom_sf
IPR020436, Somatomedin_B_chordata
IPR001212, Somatomedin_B_dom
PfamiView protein in Pfam
PF00045, Hemopexin, 1 hit
PF01033, Somatomedin_B, 2 hits
PRINTSiPR00022, SOMATOMEDINB
SMARTiView protein in SMART
SM00120, HX, 2 hits
SM00201, SO, 2 hits
SUPFAMiSSF50923, SSF50923, 1 hit
SSF90188, SSF90188, 2 hits
PROSITEiView protein in PROSITE
PS00024, HEMOPEXIN, 1 hit
PS51642, HEMOPEXIN_2, 2 hits
PS00524, SMB_1, 2 hits
PS50958, SMB_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1S2ZSG1_ERIEU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1S2ZSG1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: October 7, 2020
This is version 16 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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