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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Streptomyces sp. MUSC 93
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei747ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotation, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
ORF Names:BIV24_17030Imported
OrganismiStreptomyces sp. MUSC 93Imported
Taxonomic identifieri1428652 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000179935 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 185tRNA-synt_1gInterPro annotationAdd BLAST104
Domaini312 – 517tRNA-synt_1_2InterPro annotationAdd BLAST206
Domaini818 – 934Anticodon_1InterPro annotationAdd BLAST117

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi744 – 748"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Family and domain databases

Gene3Di3.40.50.620, 3 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1S2PD68-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSETNPAAAA AVSAEAAPHR YTAAMAAEIE ARWQDFWDAE GTYEAPNPWG
60 70 80 90 100
SPRSSEAESG GGDLAGDPEV VARPKKFIMD MFPYPSGAGL HVGHPLGYIA
110 120 130 140 150
TDVFARFQRM TGHNVLHTLG FDAFGLPAEQ YAVQTGTHPR VSTEANIENM
160 170 180 190 200
KSQLRRLGLG HDKRRSFATI EPDYYKWTQW IFLQIFNSWY DDEAKKARPI
210 220 230 240 250
SELIAQFESG ERAVPGDHGR AWNELSATER ADVLSEYRLA YASDAPVNWC
260 270 280 290 300
PGLGTVLANE EVTAEGRSER GNYPVFKAKL RQWNMRITAY ADRLLDDLEE
310 320 330 340 350
LDWPEAIKLQ QRNWIGRSEG ARVDFPIDGE AITIFTTRQD TLFGATYMVL
360 370 380 390 400
APEHPLVEKF TPETWPEGTH DVWTGGHATP AEAVAAYRAQ AASKSDVERQ
410 420 430 440 450
AEAKDKTGVF TGAYAVNPVN GEKIPVFIAD YVLMGYGTGA IMAVPAHDSR
460 470 480 490 500
DFAFARAFEL PVRCVVEPSD GRGTDASTWD DAFASYDAKI VNSTGEAVSL
510 520 530 540 550
DGLNVGDAKA RITEWLERKG IGQGTVNFRL RDWLFSRQRY WGEPFPIVYD
560 570 580 590 600
EDGIAHALPE SMLPLELPEV EDYSPRTFDP DDADTQPETP LSRNEEWVNV
610 620 630 640 650
TLDLGDGPKK YRRETNTMPN WAGSCWYELR YLDPHNDLKL VDPEIERYWM
660 670 680 690 700
GPREGMPHGG VDLYVGGAEH AVLHLLYARF WSKVLYDLGY VSSPEPFHKL
710 720 730 740 750
FNQGMIQAFV YRDSRGIAVP AAEVEERDGA YYYQGEKVSR LLGKMGKSLK
760 770 780 790 800
NAVTPDEICA EYGADTLRLY EMAMGPLDVS RPWDTRAVVG QFRLLQRLWR
810 820 830 840 850
NVVDERTGEV TVVDAEPDEE TLRALHKAID GVRQDLEGLR FNTAIAKITE
860 870 880 890 900
LNNHLTKAQG AVPRPVAESL VLLAAPLAPH VAEELWRKLG HTDSVVHRDF
910 920 930 940 950
PVADPAYVVD ETVTCVVQVK GKVKARLEVS PSISQEELEK VALADEKVVA
960 970
ALDGAGIRKV IVRAPKLVNI VTA
Length:973
Mass (Da):108,316
Last modified:April 12, 2017 - v1
Checksum:i4BB157E3DB3AD247
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MLYP01000043 Genomic DNA Translation: OIJ90884.1
RefSeqiWP_071367177.1, NZ_MLYP01000043.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MLYP01000043 Genomic DNA Translation: OIJ90884.1
RefSeqiWP_071367177.1, NZ_MLYP01000043.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.620, 3 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A1S2PD68_9ACTN
AccessioniPrimary (citable) accession number: A0A1S2PD68
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: March 28, 2018
This is version 9 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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