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Protein

Kynureninase

Gene

BNA5

Organism
Colletotrichum incanum
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-kynurenine degradation

This protein is involved in step 1 of the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Kynureninase (BNA5), Kynureninase (BNA5)
This subpathway is part of the pathway L-kynurenine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine, the pathway L-kynurenine degradation and in Amino-acid degradation.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Kynurenine 3-monooxygenase (BNA4)
  2. Kynureninase (BNA5), Kynureninase (BNA5)
  3. 3-hydroxyanthranilate 3,4-dioxygenase (BNA1)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei130Pyridoxal phosphate; via amide nitrogenUniRule annotation1
Binding sitei131Pyridoxal phosphateUniRule annotation1
Binding sitei246Pyridoxal phosphateUniRule annotation1
Binding sitei249Pyridoxal phosphateUniRule annotation1
Binding sitei271Pyridoxal phosphateUniRule annotation1
Binding sitei313Pyridoxal phosphateUniRule annotation1
Binding sitei341Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
Biological processPyridine nucleotide biosynthesisUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329
UPA00334; UER00455

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
Biosynthesis of nicotinic acid protein 5UniRule annotation
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:BNA5UniRule annotation
ORF Names:CSPAE12_11372Imported
OrganismiColletotrichum incanumImported
Taxonomic identifieri1573173 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeGlomerellalesGlomerellaceaeColletotrichum
Proteomesi
  • UP000179819 Componenti: Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei272N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini113 – 279Aminotran_5InterPro annotationAdd BLAST167

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni159 – 162Pyridoxal phosphate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01970 Kynureninase, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR010111 Kynureninase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR14084 PTHR14084, 1 hit
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
PIRSFiPIRSF038800 KYNU, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01814 kynureninase, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1S1VCH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPSSRAHAE ALDQKDALRH TRDEFVIPTK QEITSKTLAK KDEEGSTAAS
60 70 80 90 100
AGQQKCTYLC GNSLGLQPKR TAVRIQQYLS TWATQGVQGH FKPLEDSPLP
110 120 130 140 150
TWLNVDAKAA KMMAPIVGAD ESEVAVMQTL TANLHLLMAA FYKPQKEGRH
160 170 180 190 200
KIILESKAFP SDHFVVETQI RHHGLSPSES MVCIEPPSPS TESTLTTQHI
210 220 230 240 250
LTTIERHASD TALLLLPGIQ YYTGQLLDIP TITAFAHKHS ILVIWDLAHA
260 270 280 290 300
VGNVPLKLRE WDVDAAAWCT YKYLNGGPGC IGGSFVNSKH TAVTTSVEDS
310 320 330 340 350
DSEKGYVNRL GGWWGNDKSS RFVMATKFHP APGAAGFQLS NPSVLDITSL
360 370 380 390 400
CASLEVFELA GGVGALREKS LRLTGYLEEL LGAMPENERA LFRVLTPRRP
410 420 430 440 450
EERGAQLSLL LADGLLDGVM GFFDEVGVVI DERKPDVIRV APAPLYNTFA
460 470
DCFDFVEQFG KALQKTSRST
Length:470
Mass (Da):51,444
Last modified:April 12, 2017 - v1
Checksum:i8DF0BC1378C18F4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KV842185 Genomic DNA Translation: OHW90065.1

Genome annotation databases

EnsemblFungiiOHW90065; OHW90065; CSPAE12_11372

Similar proteinsi

Entry informationi

Entry nameiA0A1S1VCH1_9PEZI
AccessioniPrimary (citable) accession number: A0A1S1VCH1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: March 28, 2018
This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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