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Entry version 13 (18 Sep 2019)
Sequence version 1 (12 Apr 2017)
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Protein

Ochratoxin nonribosomal peptide synthetase

Gene

OTAnrps

Organism
Aspergillus carbonarius (strain ITEM 5010)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of ochratoxin A (OTA), a mycotoxin demonstrated to have nephrotoxic, immunotoxic, genotoxic, neurotoxic, and teratogenic properties (PubMed:24699234). OTA is composed of a chlorinated type I polyketide dihydroisocoumarin moiety linked to L-phenyl-alanine (PubMed:24699234). The highly reducing polyketide synthase (OTApks) catalyzes the formation of the isocoumarin group during the initial stages of biosynthesis, starting from one acetate and 4 malonate units, to originate the characteristic pentaketide skeleton 7-methylmellein (7-MM) of the OTA molecule (PubMed:22983973, PubMed:24699234). 7-MM is then oxidized into 7-carboxymellein (also called ochratoxin beta) (PubMed:27422838). The NRPS encoded by the OTAnrps gene is involved in the linking of phenylalanine to the dihydroisocoumarin ring (PubMed:22983973). The reaction catalyzed by NRPS results in the production of ochratoxin B (OTB), which is the non-chlorinated analog of OTA and which subsequently serves as the substrate of the halogenase (OTAhal) for chlorination activity to form the final molecular structure of OTA, containing a chlorine atom in the C-5 position of the molecule (PubMed:27422838).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Mycotoxin biosynthesis

This protein is involved in Mycotoxin biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in Mycotoxin biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
Biological processVirulence

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ochratoxin nonribosomal peptide synthetase1 Publication (EC:6.3.2.-1 Publication)
Short name:
OTAnrps1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OTAnrps1 Publication
ORF Names:ASPCADRAFT_132610
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAspergillus carbonarius (strain ITEM 5010)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri602072 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000188318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004406061 – 1875Ochratoxin nonribosomal peptide synthetaseAdd BLAST1875

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei761O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is down-regulated in the presence of fennel, cardamom, chamomile, celery, anise and rosemary essential oils (PubMed:27548221).1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A1R3RGK1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini724 – 800CarrierPROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni202 – 590Adenylation 1Sequence analysisAdd BLAST389
Regioni836 – 1245CondensationSequence analysisAdd BLAST410
Regioni1264 – 1659Adenylation 2Sequence analysisAdd BLAST396

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRP synthase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
4243at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 1 hit
3.30.559.10, 1 hit
3.40.50.12780, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071 AA_adenyl_domain
IPR036736 ACP-like_sf
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501 AMP-binding, 2 hits
PF00668 Condensation, 1 hit
PF00550 PP-binding, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823 PKS_PP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336 SSF47336, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733 AA-adenyl-dom, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455 AMP_BINDING, 1 hit
PS50075 CARRIER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1R3RGK1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTRFPHLTD GHPVEDTTLQ SITLDVGYYP SLRSTSTEQK IHVLTIAWSI
60 70 80 90 100
LLFAYEENDS VRFGLEREDG WSCVAVDVHQ EVRWQDLTVK GHGVLGEDSG
110 120 130 140 150
VNTGVCLGGQ IPMELQLVLC MDGSDSDSDS SLSMVYQPCL LSAGQAANVA
160 170 180 190 200
STVEAILQAL QGPNVPVGEI DMLGQRHVEC IAGFNLAGRD LPAGCLHGIV
210 220 230 240 250
EGQVRENGDR AAVDAWDGRL TYRELDVYAT QLSGYLVSLG LAGSFVPLCA
260 270 280 290 300
DKSVWAVVAM LAILKAGAAC SPLEPSHPRS RLESMVQTCG ARAVLVTEGY
310 320 330 340 350
ASLFQMDGVE VVVVSPDVLA LVQQTGTSLE ISPTQGSAAF LMWTSGSTGA
360 370 380 390 400
PKGVVLEHPA LSSSITAYAT ASQFTPRTRT FQFTSFTFTV SLCDLFGTMS
410 420 430 440 450
RGGCVCLPSE AQRLNDLAGA LRDFRATFCW LTSTSLASLH PSQVPDLRSI
460 470 480 490 500
TVGGESLAEE IVARWASRCR LTVSYGTTET CGWCLLNPGL SPTSDARILG
510 520 530 540 550
KPTIPAAWIT HPDDPNRLVP IGAVGELLVE GPFLARGYLH DEERTAAQFI
560 570 580 590 600
PPPAWMARFR PGETTRLYRT NDLVRYNSDG SIRFAGRRQA HAKIRGNRIN
610 620 630 640 650
LTEIESHVRR ACGTADVVVD VVSTRDRVDV LTAFMLSPGP RQPLDGPLIQ
660 670 680 690 700
QADDGFRQIV ESALHGLEDS LPSTMIPTAF VPLSRLPLTR TNKADRRLLR
710 720 730 740 750
EQAGQMSRAE LAQLAAHNRA PAESPMTAAE RVMQQLWSEL MGLPLSSIGA
760 770 780 790 800
KDSFFHLGGD SVLAIRLVPM AREHGLFLTV LDVFHHPRLG DLVAHIKDAG
810 820 830 840 850
SPGPDTWTAS PTAAEDVEHL KPEVARQCGV RPSDIEDVYP CTTLQEGLMA
860 870 880 890 900
LSAQRAGAYI LTMAYEIPPA VDVARLQEAW QTVVRALPIL RTRIVHLPSI
910 920 930 940 950
GFHQAVVDEP IAWHFVSSED EFRQSNRSNS MSLGSRLARF ALLQPDSAPA
960 970 980 990 1000
RLLLAVHHSI FDRWSAPLLL AEVEKAYAGQ AVAQQHFRGF VAYVCSRPAE
1010 1020 1030 1040 1050
ESDAFWRDRL ADASPTVFPR LPDATYLPNP TSSRDTMVVL SSSRSDFTAT
1060 1070 1080 1090 1100
SRLRLCWALL LSQHTGNTDV VFGAVSTGRS APVAGIESLI GPTLATVPLR
1110 1120 1130 1140 1150
VQINGDASVA DALQSLQEDA TAMLPHEQRG LQNIVRIGPE AKAACAFQSL
1160 1170 1180 1190 1200
LIVHASNSGS KLDLMGMMED EQLPELFSYG LTLSCEVQGP DRIHLQAFFD
1210 1220 1230 1240 1250
PRMIEEGYVE VLLSQLTHAM RQVNDVPDCK LDDLNLVSPL DEERLRTWNT
1260 1270 1280 1290 1300
AWSPAQVCVH EAIQKQSYAQ PQAEAVCSWD GSLTYASLDE RSSRLASQLH
1310 1320 1330 1340 1350
SRGVKQGAFV PLLLEKSKWT PVAMLAVMKA GGAFVLLDAS FPVERLQSIC
1360 1370 1380 1390 1400
NQLDAPIVVS SEKHRLLAGQ LSRDLLLVSA MDSDAPLTSL PPVHPDDAVY
1410 1420 1430 1440 1450
AVFTSGSTGT PKGVIINHAS YATGAHAHTT PASITPTARV LQFASYAFDA
1460 1470 1480 1490 1500
SIIEHLTTLM AGGCVCIISD EERTSSLAEA VAARKATWTW LTPSVVRALE
1510 1520 1530 1540 1550
PRDFPSLTHL CLMGESMGRT EIERWSGHVH LMQAYGPAEC SVLATLEPTL
1560 1570 1580 1590 1600
TGQSDPRNIG TPRGCNAWIV DRDDHTRLAP VGTIGELLIE GPIVGRGYHG
1610 1620 1630 1640 1650
DVVQTQAAFC EAPEWIRQFR PGQATPARVY KTGDLVQYSS RMDGSLLYIA
1660 1670 1680 1690 1700
RKDTQVKIRG QRLELSEVEY HARTAMASSS DIVVDVVSPG GRQMLALFYT
1710 1720 1730 1740 1750
DDVMHDSPCM ALPMTPDQRR FLSQVRPALE ARLPSFMVPT LWIPVTRIPL
1760 1770 1780 1790 1800
SPSRKTDRRR LQSLVGDLTP DEYKPYIIAS TSNSTQSLSK GEMKQHLSEH
1810 1820 1830 1840 1850
EILLQRLIWQ VLEGDECSSP RPRPPISMDE LFVNIGGDSL GALSLTSLAK
1860 1870
QSGFTFMAGD VLGCTLGELA RMRQE
Length:1,875
Mass (Da):204,111
Last modified:April 12, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i08BA4AFEDC8547C5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KV907504 Genomic DNA Translation: OOF93601.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
OOF93601; OOF93601; ASPCADRAFT_132610

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KV907504 Genomic DNA Translation: OOF93601.1

3D structure databases

SMRiA0A1R3RGK1
ModBaseiSearch...

Genome annotation databases

EnsemblFungiiOOF93601; OOF93601; ASPCADRAFT_132610

Phylogenomic databases

OrthoDBi4243at2759

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
3.30.559.10, 1 hit
3.40.50.12780, 2 hits
InterProiView protein in InterPro
IPR010071 AA_adenyl_domain
IPR036736 ACP-like_sf
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
PfamiView protein in Pfam
PF00501 AMP-binding, 2 hits
PF00668 Condensation, 1 hit
PF00550 PP-binding, 1 hit
SMARTiView protein in SMART
SM00823 PKS_PP, 1 hit
SUPFAMiSSF47336 SSF47336, 1 hit
TIGRFAMsiTIGR01733 AA-adenyl-dom, 2 hits
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit
PS50075 CARRIER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOTA2_ASPC5
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1R3RGK1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2017
Last sequence update: April 12, 2017
Last modified: September 18, 2019
This is version 13 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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