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Entry version 17 (17 Jun 2020)
Sequence version 1 (12 Apr 2017)
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Protein
Submitted name:

Putative regulator of g protein signaling

Gene
N/A
Organism
Culex tarsalis (Encephalitis mosquito)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Putative regulator of g protein signalingImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCulex tarsalis (Encephalitis mosquito)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7177 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeCulicinaeCuliciniCulexCulex

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 109PDZInterPro annotationAdd BLAST78
Domaini892 – 1005RGSInterPro annotationAdd BLAST114
Domaini1147 – 1217RBDInterPro annotationAdd BLAST71
Domaini1218 – 1286RBDInterPro annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni396 – 452DisorderedSequence analysisAdd BLAST57
Regioni658 – 681DisorderedSequence analysisAdd BLAST24
Regioni772 – 840DisorderedSequence analysisAdd BLAST69
Regioni1041 – 1110DisorderedSequence analysisAdd BLAST70
Regioni1365 – 1385DisorderedSequence analysisAdd BLAST21
Regioni1406 – 1468DisorderedSequence analysisAdd BLAST63
Regioni1531 – 1622DisorderedSequence analysisAdd BLAST92

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi429 – 452PolarSequence analysisAdd BLAST24
Compositional biasi798 – 840PolarSequence analysisAdd BLAST43
Compositional biasi1065 – 1079PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1367 – 1381PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1423 – 1438PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1531 – 1555PolarSequence analysisAdd BLAST25
Compositional biasi1575 – 1591PolarSequence analysisAdd BLAST17
Compositional biasi1608 – 1622PolarSequence analysisAdd BLAST15

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.196.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003109 GoLoco_motif
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR003116 RBD_dom
IPR016137 RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
IPR029071 Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00595 PDZ, 1 hit
PF02196 RBD, 1 hit
PF00615 RGS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01301 RGSPROTEIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00390 GoLoco, 1 hit
SM00228 PDZ, 1 hit
SM00462 PTB, 1 hit
SM00455 RBD, 2 hits
SM00315 RGS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48097 SSF48097, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50877 GOLOCO, 1 hit
PS50106 PDZ, 1 hit
PS50898 RBD, 2 hits
PS50132 RGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

A0A1Q3FV14-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
NGYEFPLISV NLWVKMHGHR RRKKRPNYGL RTVEVNRGLH GFGFTISGQQ
60 70 80 90 100
PCILSCIVGN SPADLAGLRA GDFLISVNGL NVSKLPHEAV VQLIGSTYGA
110 120 130 140 150
IKMAIAENYY SDSSDEDGLF QGSTQHRVRP KYLNHKTKFQ QRMTSAKQHT
160 170 180 190 200
SMNGPADLVG TCEAATAIVV NDSPTAYNVI HSPNASNSCD ISNVSAMVRS
210 220 230 240 250
VQLEDEEAGP SQQPDREIAL EYKAIVGYLG TIEMPKQIAT SSKLQTVRSC
260 270 280 290 300
IRKMRQEKRN PTTVLMTILP SCLNLINTSN AVIAKYSSVR LSYVSSSSES
310 320 330 340 350
DNRYFGLVTS AIYADGLMCE SAEILNQRKD VVISNSCHVF VIDARMVDHA
360 370 380 390 400
AHLEKADLFQ LVCTKDPITN LCLEFPSNSE YVVNLIRSMY NLKAPPLKPS
410 420 430 440 450
DSYGKPPVAR SLNLDRRANP REDPHDLLAS NSPQPSNHSE ITTTSSNSDS
460 470 480 490 500
GIGFHNDCRN ISDRILVVDF PGGNHQINNV RAHFRKSVPF GRPVGIINEL
510 520 530 540 550
PQPLDPIRNI RSTTSSTGPQ IFHGKSKSAD YGYQPSGLDR LTVRARPDPK
560 570 580 590 600
LFPPDRSPSK DNALNHDYAL FPAADLPQQT VDDAGNVVQE RPVDIPAQLA
610 620 630 640 650
HSPTFLDLQR YNADNVKNSL LARSCDDMIL TLEKEEPEPP PPKAVDDQHV
660 670 680 690 700
FLQPAKPIKR AKKACSHRPG SRQPADDGSS KLLSYKLSPK VFGLARPLAA
710 720 730 740 750
SFENIPTGDE VGEKTRKMDA SAEVQPERSR AAKRLSGGFS AIWGSLQELR
760 770 780 790 800
SGGGGSKQTE VEPGERVVMK KLQLQQERRP VLPGAFSEPD LRCDENKQIN
810 820 830 840 850
HNASPFRRWG QSSLRSRSGE QRTPSSSHRR PSSLAASESD VYTKSIDDDY
860 870 880 890 900
SSTKSGYNPY VDAASALTTT ESTQTSTTVS SGPAGVASWG TSFEKLLEDP
910 920 930 940 950
AGLHTFSEFL KKEFSAENIY FWTACERYRQ LVDREERAKE AQAIFAKHLE
960 970 980 990 1000
SGCSEPVNVD SIARNIAQEN LPQAEQTLFG AASKQIFNLM KFDSYQRFIK
1010 1020 1030 1040 1050
SDMYRTCQEA EAKGHPLPYP GDQLDPLLRT SFAVQTAATK LKKSLSNAED
1060 1070 1080 1090 1100
RRRKSLLPWH RKTRCKSKDR GDSELKKESG GGNKATLSAG GGGSGGGGGN
1110 1120 1130 1140 1150
GTGGSSNTLK VLSTNSTSDI HSSRSSLASF DAAIGKSYDQ EDQTRNTLCR
1160 1170 1180 1190 1200
VILSNGATTV VQTRSNETIK ELVERLLEKR GIVYTAYEAF LAGNHKPLDL
1210 1220 1230 1240 1250
DGPSSSLAGR EVNIDQRVVF KLSLPNRKMI SVKSKATKPL GDVLRPILLK
1260 1270 1280 1290 1300
YNYELDQMNV YSKEAYLDMT YPVTSVDGLW LQVRNGNENE FHQDLTRTIA
1310 1320 1330 1340 1350
SRSERAYANQ VPPLPIIATS QHAQIINHFQ QQLQHSQHNG FLNNNNNNNV
1360 1370 1380 1390 1400
TKKSQLAYAG QIHNNNNHVK GKDEQSAKED AAVGGKQELN MLDEITNKVF
1410 1420 1430 1440 1450
NELMNGKIAN GPKVPPEDCT SDSSSTRRGD RFRRRGSNAP SESGRGAKSK
1460 1470 1480 1490 1500
KCSTAGSEDG GESVGNAATG MKKPIIAKLK AGVKLQIPTR SQNDELLEGL
1510 1520 1530 1540 1550
KRAQRSRLED QRGTEINFEL PDFLKDKENF TSTTTAGSSS AATGSGANSA
1560 1570 1580 1590 1600
AMAAPSSKFT RKFGKRPESA EFPLCASTNG GSLQQIHKPQ PAPRLSISRG
1610 1620 1630 1640 1650
GGATAPGANP SSPVQSASSE SNLNNLSLRC NASPLTLDDN GNGSQSENSY
1660
AGSFSSVIEI AMGVK
Length:1,665
Mass (Da):181,765
Last modified:April 12, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBCFEFA3D9C41A645
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GFDL01003753 Transcribed RNA Translation: JAV31292.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GFDL01003753 Transcribed RNA Translation: JAV31292.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di1.10.196.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR003109 GoLoco_motif
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR003116 RBD_dom
IPR016137 RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PF02196 RBD, 1 hit
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00390 GoLoco, 1 hit
SM00228 PDZ, 1 hit
SM00462 PTB, 1 hit
SM00455 RBD, 2 hits
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS50877 GOLOCO, 1 hit
PS50106 PDZ, 1 hit
PS50898 RBD, 2 hits
PS50132 RGS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1Q3FV14_CULTA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1Q3FV14
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: June 17, 2020
This is version 17 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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