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Protein

Malate dehydrogenase

Gene

mdh

Organism
Microbulbifer agarilyticus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotationSAAS annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei92SubstrateUniRule annotation1
Binding sitei98SubstrateUniRule annotation1
Binding sitei105NADUniRule annotation1
Binding sitei112NADUniRule annotation1
Binding sitei131SubstrateUniRule annotation1
Binding sitei162SubstrateUniRule annotation1
Active sitei187Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 17NADUniRule annotation7
Nucleotide bindingi129 – 131NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processTricarboxylic acid cycleUniRule annotation
LigandNADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotationSAAS annotation (EC:1.1.1.37UniRule annotationSAAS annotation)
Gene namesi
Name:mdhUniRule annotation
ORF Names:Mag101_08825Imported
OrganismiMicrobulbifer agarilyticusImported
Taxonomic identifieri260552 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaCellvibrionalesMicrobulbiferaceaeMicrobulbifer
Proteomesi
  • UP000188219 Componenti: Chromosome

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 152Ldh_1_NInterPro annotationAdd BLAST148
Domaini156 – 322Ldh_1_CInterPro annotationAdd BLAST167

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili300 – 320Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

KOiK00024

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_01517 Malate_dehydrog_2, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR001252 Malate_DH_AS
IPR010945 Malate_DH_type2
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23382 PTHR23382, 1 hit
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01759 MalateDH-SF1, 1 hit
PROSITEiView protein in PROSITE
PS00068 MDH, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1Q2M513-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAPVRVAVT GAAGQISYSL LFRIASGEML GKDQPVILQL LEITPALEAL
60 70 80 90 100
KGVAMELEDC AFPLLAGIVQ SDDATVAFKD ADYALLVGAR PRGPGMERKD
110 120 130 140 150
LLEANAAIFS AQGKALNDVA SRDVKVLVVG NPANTNALIA QRNAPDLDPR
160 170 180 190 200
NFTAMTRLDH NRALTQLANK TDSTVNDITH MTIWGNHSAT QYPDLHQAKV
210 220 230 240 250
NGEDAMGKVE QEWYETDFIP TVQQRGAAII KARGASSAAS AANAAIDHMR
260 270 280 290 300
DWALGSAEGD WTSMGVYSDG SYGIAKGLIY SFPVVCKNGD WEIVQGVDIN
310 320
DFSREKMTAT EQELAEERDA VAHLLP
Length:326
Mass (Da):35,069
Last modified:April 12, 2017 - v1
Checksum:i9BF40F956A53C2E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP019650 Genomic DNA Translation: AQQ67730.1

Genome annotation databases

KEGGimaga:Mag101_08825

Similar proteinsi

Entry informationi

Entry nameiA0A1Q2M513_9GAMM
AccessioniPrimary (citable) accession number: A0A1Q2M513
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: July 18, 2018
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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