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Protein

Probable nicotinate-nucleotide adenylyltransferase

Gene

nadD

Organism
Anaerostipes hadrus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).UniRule annotation

Catalytic activityi

ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD+.UniRule annotationSAAS annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable nicotinate-nucleotide adenylyltransferase (nadD), Probable nicotinate-nucleotide adenylyltransferase (nadD), Probable nicotinate-nucleotide adenylyltransferase (nadD)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processPyridine nucleotide biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, NADUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00332

Names & Taxonomyi

Protein namesi
Recommended name:
Probable nicotinate-nucleotide adenylyltransferaseUniRule annotation (EC:2.7.7.18UniRule annotation)
Alternative name(s):
Deamido-NAD(+) diphosphorylaseUniRule annotation
Deamido-NAD(+) pyrophosphorylaseUniRule annotation
Nicotinate mononucleotide adenylyltransferaseUniRule annotation
Short name:
NaMN adenylyltransferaseUniRule annotation
Gene namesi
Name:nadDUniRule annotation
ORF Names:DO83_13195Imported
OrganismiAnaerostipes hadrusImported
Taxonomic identifieri649756 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceaeAnaerostipes
Proteomesi
  • UP000188159 Componenti: Chromosome

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 173CTP_transf_likeInterPro annotationAdd BLAST168

Sequence similaritiesi

Belongs to the NadD family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd02165 NMNAT, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00244 NaMN_adenylyltr, 1 hit
InterProiView protein in InterPro
IPR004821 Cyt_trans-like
IPR005248 NadD/NMNAT
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF01467 CTP_transf_like, 1 hit
TIGRFAMsiTIGR00125 cyt_tran_rel, 1 hit
TIGR00482 TIGR00482, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1Q2C9N0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKIGILGGT FNPIHHGHLI LGQAAKEEFG LDEILVMPTK NPAYKTISGG
60 70 80 90 100
VSEKNRVDMI KLAIRDFPYF KFSDIELKRE GTTYTVDTLR ELTKQDTDCR
110 120 130 140 150
YYFIMGADSL YQIETWKDPG QIFTMADILV ATRNDSRSAL DAQIDYLEEK
160 170 180 190 200
YDGKIYHLSS PSIEISSNDI RKRCSNGSSI HFFLPEDVID YIERNDLYGS

TADRRKA
Length:207
Mass (Da):23,636
Last modified:April 12, 2017 - v1
Checksum:i171A9F731BF150E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP012098 Genomic DNA Translation: AQP40446.1

Similar proteinsi

Entry informationi

Entry nameiA0A1Q2C9N0_ANAHA
AccessioniPrimary (citable) accession number: A0A1Q2C9N0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: March 28, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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