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Protein

Pectinesterase

Gene

PMEPCRF

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Pectin + n H2O = n methanol + pectate.UniRule annotationSAAS annotation

Pathwayi: pectin degradation

This protein is involved in step 1 of the subpathway that synthesizes 2-dehydro-3-deoxy-D-gluconate from pectin.UniRule annotationSAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Pectinesterase PPME1 (PPME1), Probable pectinesterase/pectinesterase inhibitor 44 (PME44), Putative pectinesterase 11 (PME11), Probable pectinesterase 15 (PME15), Probable pectinesterase/pectinesterase inhibitor 60 (PME60), Probable pectinesterase 67 (PME67), Probable pectinesterase/pectinesterase inhibitor 25 (PME25), Probable pectinesterase/pectinesterase inhibitor 33 (PME33), Probable pectinesterase/pectinesterase inhibitor 41 (PME41), Putative pectinesterase/pectinesterase inhibitor 45 (PME45), Probable pectinesterase/pectinesterase inhibitor 47 (PME47), Probable pectinesterase 49 (PME49), Probable pectinesterase/pectinesterase inhibitor 13 (PME13), Probable pectinesterase 50 (PME50), Probable pectinesterase/pectinesterase inhibitor 54 (PME54), Probable pectinesterase/pectinesterase inhibitor 61 (PME61), Pectinesterase QRT1 (QRT1), Putative pectinesterase 63 (PME63), Probable pectinesterase 30 (PME30), Pectinesterase 31 (PME31), Probable pectinesterase/pectinesterase inhibitor 36 (PME36), Pectinesterase/pectinesterase inhibitor 18 (PME18), Probable pectinesterase/pectinesterase inhibitor 19 (PME19), Probable pectinesterase/pectinesterase inhibitor 23 (PME23), Putative pectinesterase/pectinesterase inhibitor 28 (PME28), Putative pectinesterase/pectinesterase inhibitor 43 (PME43), Probable pectinesterase/pectinesterase inhibitor 46 (PME46), Probable pectinesterase 48 (PME48), Pectinesterase 4 (PME4), Putative pectinesterase 14 (PME14), Probable pectinesterase 55 (PME55), Probable pectinesterase 56 (PME56), Probable pectinesterase 66 (PME66), Probable pectinesterase/pectinesterase inhibitor 20 (PME20), Probable pectinesterase 8 (PME8), Probable pectinesterase/pectinesterase inhibitor 39 (PME39), Pectinesterase/pectinesterase inhibitor 3 (PME3), Putative pectinesterase 52 (PME52), Probable pectinesterase/pectinesterase inhibitor 59 (PME59), Probable pectinesterase/pectinesterase inhibitor 64 (PME64), Probable pectinesterase/pectinesterase inhibitor 21 (PME21), Putative pectinesterase/pectinesterase inhibitor 22 (PME22), Putative pectinesterase/pectinesterase inhibitor 24 (PME24), Putative pectinesterase/pectinesterase inhibitor 26 (PME26), Pectinesterase 2 (PME2), Probable pectinesterase/pectinesterase inhibitor VGDH2 (VGDH2), Probable pectinesterase/pectinesterase inhibitor 12 (PME12), Probable pectinesterase 53 (PME53), Probable pectinesterase/pectinesterase inhibitor 16 (PME16), Pectinesterase 1 (PME1), Probable pectinesterase/pectinesterase inhibitor 34 (PME34), Probable pectinesterase/pectinesterase inhibitor 40 (PME40), Probable pectinesterase/pectinesterase inhibitor 42 (PME42), Putative pectinesterase 10 (PME10), Probable pectinesterase/pectinesterase inhibitor 51 (PME51), Putative pectinesterase 57 (PME57), Probable pectinesterase/pectinesterase inhibitor 58 (PME58), Probable pectinesterase/pectinesterase inhibitor 17 (PME17), Pectinesterase 5 (PME5), Probable pectinesterase 68 (PME68), Probable pectinesterase/pectinesterase inhibitor 6 (PME6), Probable pectinesterase/pectinesterase inhibitor 7 (PME7), Probable pectinesterase 29 (PME29), Probable pectinesterase/pectinesterase inhibitor 32 (PME32), Probable pectinesterase/pectinesterase inhibitor 35 (PME35), Putative pectinesterase/pectinesterase inhibitor 38 (PME38), Uncharacterized protein (AXX17_At3g05180), Pectinesterase (AXX17_At5g52320), Pectinesterase (AXX17_At3g17940), Pectinesterase (AXX17_At3g53530), Pectinesterase (AXX17_At5g50300), PME26 (AXX17_At3g14890), Pectinesterase (AXX17_At4g02940), Pectinesterase (At4g15980), Pectinesterase (At3g14310), Plant invertase/pectin methylesterase inhibitor superfamily (At5g09760), Pectinesterase (At5g26810), Pectinesterase (AXX17_At3g36460), Pectinesterase (AXX17_At4g00230), Pectinesterase (AXX17_At5g04420), Pectinesterase (AXX17_At2g45340), Pectinesterase (At3g10720), Pectinesterase (AXX17_At5g04430), Pectinesterase (AXX17_At1g11890), Uncharacterized protein (AXX17_At5g27870), Pectinesterase (PMEPCRA), Pectinesterase (AXX17_At5g50310), Uncharacterized protein (AXX17_At5g64270), Pectinesterase (AXX17_At3g31890), Pectinesterase (AXX17_At5g20800), Pectinesterase (AXX17_At3g06710), Pectinesterase (AXX17_At3g55110), Pectinesterase (At5g20860), Pectinesterase (AXX17_At4g38040), Pectinesterase (AXX17_At1g04730), Pectinesterase (AXX17_At1g11900), Pectinesterase (AXX17_At2g33410), Pectinesterase, Pectinesterase (AXX17_At2g22270), Pectinesterase (AXX17_At2g40510), Pectinesterase (AXX17_At2g44780), Pectinesterase (AXX17_At4g18720), Pectinesterase (AXX17_At4g02930), Pectinesterase (AXX17_At5g47900), Pectinesterase (AXX17_At4g38050), Pectinesterase (AXX17_At3g56460), Pectinesterase (AXX17_At1g11920), Pectinesterase (At3g49220), Pectinesterase (AXX17_At3g41380), Pectinesterase (AXX17_At1g24390), Pectinesterase (AXX17_At1g48300), Pectinesterase (AXX17_At2g42790), Pectinesterase (AXX17_At5g19650), Pectinesterase, Pectinesterase (AXX17_At3g05190), Pectinesterase (AXX17_At3g30550), Pectinesterase (AXX17_At4g06570), Pectinesterase (At1g53840), Pectinesterase, Pectinesterase (AXX17_At4g02900), Pectinesterase (AXX17_At2g33420), Pectinesterase (AXX17_At2g33420), Pectinesterase (AXX17_At5g45990), Pectinesterase (AXX17_At2g44790), Pectinesterase (F14I3.7), Pectinesterase (AXX17_At3g10560), Pectinesterase (AXX17_At1g01970), Pectinesterase (AXX17_At3g26070), Pectinesterase (AXX17_At3g14900), Pectinesterase (AXX17_At3g10570), Pectinesterase (AXX17_At3g43380), Plant invertase/pectin methylesterase inhibitor superfamily (At3g49220), Pectinesterase (PME44), Pectinesterase (PMEPCRF), Pectinesterase (AXX17_At1g48290), Pectinesterase, Pectinesterase (AXX17_At2g22280)
  2. Probable pectate lyase 10 (At3g24670), Putative pectate lyase 11 (At3g27400), Probable pectate lyase 15 (At4g13710), Probable pectate lyase 18 (At4g24780), Probable pectate lyase 1 (At1g04680), Putative pectate lyase 14 (At4g13210), Probable pectate lyase 19 (At5g15110), Putative pectate lyase 21 (At5g55720), Probable pectate lyase 22 (At5g63180), Putative pectate lyase 2 (At1g11920), Probable pectate lyase 3 (AT59), Probable pectate lyase 5 (At1g67750), Probable pectate lyase 6 (At2g02720), Probable pectate lyase 7 (At3g01270), Probable pectate lyase 16 (At4g22080), Putative pectate lyase 17 (At4g22090), Probable pectate lyase 13 (PMR6), Probable pectate lyase 12 (At3g53190), Probable pectate lyase 20 (At5g48900), Probable pectate lyase 4 (At1g30350), Probable pectate lyase 8 (At3g07010), Probable pectate lyase 9 (At3g24230), Pectate lyase (At3g01270), Pectate lyase (At3g09540), Pectate lyase (AXX17_At3g09180), Pectate lyase (At5g09280), Pectate lyase (At5g04310), Pectate lyase (F11F8_12), Pectate lyase (At1g14420), Pectate lyase (At3g55140), Pectate lyase (AXX17_At4g28670), Pectate lyase, Pectate lyase (At3g27400), Pectate lyase (AXX17_At5g03700), Pectate lyase (AXX17_At4g25610), Pectate lyase (AXX17_At3g00310), Pectate lyase (AXX17_At3g49720), Pectate lyase (At3g07010), Pectate lyase (AXX17_At3g06910), Pectate lyase (AXX17_At3g47590), Pectate lyase (At5g04310), Pectate lyase (At4g13710), Pectate lyase, Pectate lyase (At3g53190), Pectate lyase (AXX17_At4g25600), Pectate lyase (AXX17_At3g49450), Pectate lyase (AXX17_At5g08800), Pectate lyase (At4g13210), Pectate lyase (At3g55140), Pectate lyase (At3g01270), Pectate lyase (AXX17_At4g15660), Pectate lyase (T26I12.20), Pectate lyase (AXX17_At2g01680), Pectate lyase (AXX17_At3g26720), Pectate lyase (AXX17_At5g14600), Pectate lyase (AXX17_At1g04020), Pectate lyase (AXX17_At1g12300), Pectate lyase (At3g07010), Pectate lyase (AXX17_At1g15010), Pectate lyase (AXX17_At1g30780), Pectate lyase (AXX17_At5g47570), Pectate lyase, Pectate lyase (AXX17_At3g29900), Pectate lyase (AXX17_At5g54880), Pectate lyase (AXX17_At1g61710), Pectate lyase (AXX17_At4g14900), Pectate lyase (AXX17_At3g26200), Pectate lyase (At3g07010), Pectate lyase (AXX17_At5g62760), Pectate lyase
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway pectin degradation, which is itself part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-dehydro-3-deoxy-D-gluconate from pectin, the pathway pectin degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei459PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAspartyl esteraseUniRule annotationSAAS annotation, Hydrolase

Enzyme and pathway databases

UniPathwayi
UPA00545;UER00823

Names & Taxonomyi

Protein namesi
Recommended name:
PectinesteraseUniRule annotation (EC:3.1.1.11UniRule annotation)
Gene namesi
Name:PMEPCRFImported
Synonyms:ATPMEPCRFImported
Ordered Locus Names:At5g53370Imported
ORF Names:K19E1.17Imported, K19E1_17Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 25HelicalSequence analysisAdd BLAST20
Transmembranei70 – 91HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

ExpressionAtlasiA0A1P8BGK2 baseline and differential

Structurei

3D structure databases

SMRiA0A1P8BGK2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini106 – 259PMEIInterPro annotationAdd BLAST154

Sequence similaritiesi

In the C-terminal section; belongs to the pectinesterase family.SAAS annotation
In the N-terminal section; belongs to the PMEI family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3Di1.20.140.40, 1 hit
2.160.20.10, 1 hit
InterProiView protein in InterPro
IPR035513 Invertase/methylesterase_inhib
IPR012334 Pectin_lyas_fold
IPR011050 Pectin_lyase_fold/virulence
IPR033131 Pectinesterase_Asp_AS
IPR000070 Pectinesterase_cat
IPR006501 Pectinesterase_inhib_dom
PfamiView protein in Pfam
PF01095 Pectinesterase, 1 hit
PF04043 PMEI, 1 hit
SMARTiView protein in SMART
SM00856 PMEI, 1 hit
SUPFAMiSSF101148 SSF101148, 1 hit
SSF51126 SSF51126, 1 hit
TIGRFAMsiTIGR01614 PME_inhib, 1 hit
PROSITEiView protein in PROSITE
PS00503 PECTINESTERASE_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A1P8BGK2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTFLFLNSSF YIIIYRAFHI SFVPLTNSKP KKKKKTMGYD RLGPSGPSNP
60 70 80 90 100
NQKDPATSLP ELQKKTKTKL ILFTLAVLVV GVVCFGIFAG IRAVDSGKTE
110 120 130 140 150
PKLTRKPTQA ISRTCSKSLY PNLCIDTLLD FPGSLTADEN ELIHISFNAT
160 170 180 190 200
LQKFSKALYT SSTITYTQMP PRVRSAYDSC LELLDDSVDA LTRALSSVVV
210 220 230 240 250
VSGDESHSDV MTWLSSAMTN HDTCTDGFDE IEGQGGEVKD QVIGAVKDLS
260 270 280 290 300
EMVSNCLAIF AGKVKDLSGV PVVNNRKLLG TEETEELPNW LKREDRELLG
310 320 330 340 350
TPTSAIQADI TVSKDGSGTF KTIAEAIKKA PEHSSRRFVI YVKAGRYEEE
360 370 380 390 400
NLKVGRKKTN LMFIGDGKGK TVITGGKSIA DDLTTFHTAT FAATGAGFIV
410 420 430 440 450
RDMTFENYAG PAKHQAVALR VGGDHAVVYR CNIIGYQDAL YVHSNRQFFR
460 470 480 490 500
ECEIYGTVDF IFGNAAVILQ SCNIYARKPM AQQKITITAQ NRKDPNQNTG
510 520 530 540 550
ISIHACKLLA TPDLEASKGS YPTYLGRPWK LYSRVVYMMS DMGDHIDPRG
560 570 580 590 600
WLEWNGPFAL DSLYYGEYMN KGLGSGIGQR VKWPGYHVIT STVEASKFTV
610 620
AQFISGSSWL PSTGVSFFSG LSQ
Length:623
Mass (Da):68,533
Last modified:April 12, 2017 - v1
Checksum:i0F698EEC11B6F737
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9FK05PME61_ARATH
Probable pectinesterase/pectinester...
PME61 ARATH61, At5g53370, K19E1.17
587Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002688 Genomic DNA Translation: ANM70677.1
RefSeqiNP_001332265.1, NM_001345052.1
UniGeneiAt.24561
At.29558

Genome annotation databases

EnsemblPlantsiAT5G53370.2; AT5G53370.2; AT5G53370
GeneIDi835418
GrameneiAT5G53370.2; AT5G53370.2; AT5G53370

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002688 Genomic DNA Translation: ANM70677.1
RefSeqiNP_001332265.1, NM_001345052.1
UniGeneiAt.24561
At.29558

3D structure databases

SMRiA0A1P8BGK2
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G53370.2; AT5G53370.2; AT5G53370
GeneIDi835418
GrameneiAT5G53370.2; AT5G53370.2; AT5G53370

Enzyme and pathway databases

UniPathwayi
UPA00545;UER00823

Gene expression databases

ExpressionAtlasiA0A1P8BGK2 baseline and differential

Family and domain databases

Gene3Di1.20.140.40, 1 hit
2.160.20.10, 1 hit
InterProiView protein in InterPro
IPR035513 Invertase/methylesterase_inhib
IPR012334 Pectin_lyas_fold
IPR011050 Pectin_lyase_fold/virulence
IPR033131 Pectinesterase_Asp_AS
IPR000070 Pectinesterase_cat
IPR006501 Pectinesterase_inhib_dom
PfamiView protein in Pfam
PF01095 Pectinesterase, 1 hit
PF04043 PMEI, 1 hit
SMARTiView protein in SMART
SM00856 PMEI, 1 hit
SUPFAMiSSF101148 SSF101148, 1 hit
SSF51126 SSF51126, 1 hit
TIGRFAMsiTIGR01614 PME_inhib, 1 hit
PROSITEiView protein in PROSITE
PS00503 PECTINESTERASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A1P8BGK2_ARATH
AccessioniPrimary (citable) accession number: A0A1P8BGK2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: October 10, 2018
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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