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Protein

Pectinesterase

Gene

At4g15980

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Acts in the modification of cell walls via demethylesterification of cell wall pectin.UniRule annotation

Catalytic activityi

Pectin + n H2O = n methanol + pectate.UniRule annotationSAAS annotation

Pathwayi: pectin degradation

This protein is involved in step 1 of the subpathway that synthesizes 2-dehydro-3-deoxy-D-gluconate from pectin.UniRule annotationSAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Putative pectinesterase/pectinesterase inhibitor 26 (PME26), Putative pectinesterase/pectinesterase inhibitor 28 (PME28), Probable pectinesterase/pectinesterase inhibitor 33 (PME33), Probable pectinesterase/pectinesterase inhibitor 40 (PME40), Probable pectinesterase/pectinesterase inhibitor 13 (PME13), Probable pectinesterase/pectinesterase inhibitor 19 (PME19), Probable pectinesterase/pectinesterase inhibitor 25 (PME25), Probable pectinesterase/pectinesterase inhibitor 34 (PME34), Probable pectinesterase/pectinesterase inhibitor 36 (PME36), Pectinesterase/pectinesterase inhibitor 3 (PME3), Probable pectinesterase/pectinesterase inhibitor 47 (PME47), Probable pectinesterase/pectinesterase inhibitor 12 (PME12), Probable pectinesterase/pectinesterase inhibitor 21 (PME21), Probable pectinesterase/pectinesterase inhibitor 60 (PME60), Probable pectinesterase 66 (PME66), Probable pectinesterase 8 (PME8), Putative pectinesterase 11 (PME11), Probable pectinesterase 15 (PME15), Putative pectinesterase/pectinesterase inhibitor 22 (PME22), Probable pectinesterase 29 (PME29), Putative pectinesterase/pectinesterase inhibitor 38 (PME38), Putative pectinesterase 14 (PME14), Pectinesterase/pectinesterase inhibitor 18 (PME18), Pectinesterase 2 (PME2), Probable pectinesterase/pectinesterase inhibitor 42 (PME42), Probable pectinesterase/pectinesterase inhibitor 64 (PME64), Probable pectinesterase 48 (PME48), Probable pectinesterase/pectinesterase inhibitor 39 (PME39), Probable pectinesterase 53 (PME53), Probable pectinesterase/pectinesterase inhibitor 54 (PME54), Probable pectinesterase 67 (PME67), Putative pectinesterase/pectinesterase inhibitor 24 (PME24), Probable pectinesterase/pectinesterase inhibitor 35 (PME35), Probable pectinesterase/pectinesterase inhibitor VGDH2 (VGDH2), Probable pectinesterase/pectinesterase inhibitor 6 (PME6), Probable pectinesterase/pectinesterase inhibitor 16 (PME16), Probable pectinesterase 50 (PME50), Probable pectinesterase 30 (PME30), Pectinesterase 31 (PME31), Probable pectinesterase/pectinesterase inhibitor 58 (PME58), Probable pectinesterase/pectinesterase inhibitor 32 (PME32), Probable pectinesterase/pectinesterase inhibitor 44 (PME44), Probable pectinesterase/pectinesterase inhibitor 46 (PME46), Probable pectinesterase/pectinesterase inhibitor 23 (PME23), Probable pectinesterase/pectinesterase inhibitor 41 (PME41), Probable pectinesterase 56 (PME56), Probable pectinesterase/pectinesterase inhibitor 59 (PME59), Probable pectinesterase/pectinesterase inhibitor 61 (PME61), Putative pectinesterase/pectinesterase inhibitor 45 (PME45), Pectinesterase 4 (PME4), Probable pectinesterase/pectinesterase inhibitor 20 (PME20), Probable pectinesterase/pectinesterase inhibitor 51 (PME51), Pectinesterase QRT1 (QRT1), Putative pectinesterase 63 (PME63), Probable pectinesterase/pectinesterase inhibitor 7 (PME7), Putative pectinesterase/pectinesterase inhibitor 43 (PME43), Putative pectinesterase 10 (PME10), Probable pectinesterase/pectinesterase inhibitor 17 (PME17), Putative pectinesterase 52 (PME52), Putative pectinesterase 57 (PME57), Pectinesterase 5 (PME5), Pectinesterase 1 (PME1), Probable pectinesterase 55 (PME55), Probable pectinesterase 68 (PME68), Probable pectinesterase 49 (PME49), Pectinesterase PPME1 (PPME1), Pectinesterase (AXX17_At3g36460), Pectinesterase (PMEPCRF), Pectinesterase (AXX17_At5g20800), Pectinesterase (At3g10720), Pectinesterase (AXX17_At5g50310), Pectinesterase (AXX17_At1g11890), Pectinesterase (AXX17_At2g42790), Pectinesterase (AXX17_At3g06710), Pectinesterase (AXX17_At3g10570), Pectinesterase (AXX17_At1g04730), Pectinesterase (AXX17_At2g44780), Pectinesterase (AXX17_At1g48300), Pectinesterase (AXX17_At2g33420), Pectinesterase (AXX17_At2g45340), Pectinesterase (AXX17_At1g24390), Pectinesterase (AXX17_At2g22270), PME26 (AXX17_At3g14890), Pectinesterase (AXX17_At1g11900), Pectinesterase (AXX17_At3g31890), Pectinesterase, Pectinesterase (AXX17_At5g45990), Pectinesterase, Pectinesterase (AXX17_At3g43380), Pectinesterase (At4g15980), Pectinesterase (AXX17_At1g01970), Pectinesterase (F14I3.7), Pectinesterase (AXX17_At5g19650), Pectinesterase (AXX17_At4g02930), Pectinesterase (AXX17_At4g02900), Pectinesterase (At3g14310), Pectinesterase (AXX17_At3g14900), Pectinesterase (AXX17_At3g53530), Pectinesterase (AXX17_At3g30550), Pectinesterase (AXX17_At1g11920), Pectinesterase (PMEPCRA), Pectinesterase (AXX17_At5g04420), Uncharacterized protein (AXX17_At5g27870), Pectinesterase (AXX17_At5g50300), Pectinesterase (AXX17_At2g44790), Pectinesterase (AXX17_At5g04430), Pectinesterase (AXX17_At4g38040), Pectinesterase (AXX17_At4g00230), Uncharacterized protein (AXX17_At5g64270), Uncharacterized protein (AXX17_At5g09310), Pectinesterase (AXX17_At2g33410), Pectinesterase (AXX17_At2g40510), Pectinesterase (AXX17_At4g02940), Pectinesterase (AXX17_At3g41380), Pectinesterase (AXX17_At4g18720), Pectinesterase (AXX17_At3g05190), Plant invertase/pectin methylesterase inhibitor superfamily (At5g09760), Pectinesterase (AXX17_At3g55110), Pectinesterase (AXX17_At2g33420), Pectinesterase (AXX17_At5g47900), Uncharacterized protein (AXX17_At3g05180), Pectinesterase (AXX17_At4g06570), Pectinesterase (At1g53840), Pectinesterase (AXX17_At4g38050), Pectinesterase (AXX17_At3g56460), Pectinesterase (PME44), Pectinesterase (At3g49220), Pectinesterase (AXX17_At3g26070), Pectinesterase (AXX17_At3g17940), Pectinesterase, Plant invertase/pectin methylesterase inhibitor superfamily (At3g49220), Pectinesterase (AXX17_At3g10560), Pectinesterase (AXX17_At5g52320), Pectinesterase (At5g20860), Pectinesterase (At5g26810), Pectinesterase (AXX17_At5g26780), Pectinesterase (AXX17_At2g22280), Pectinesterase (AXX17_At1g48290), Pectinesterase
  2. Probable pectate lyase 13 (PMR6), Putative pectate lyase 21 (At5g55720), Probable pectate lyase 3 (AT59), Putative pectate lyase 17 (At4g22090), Probable pectate lyase 18 (At4g24780), Probable pectate lyase 22 (At5g63180), Probable pectate lyase 16 (At4g22080), Probable pectate lyase 5 (At1g67750), Probable pectate lyase 1 (At1g04680), Putative pectate lyase 14 (At4g13210), Probable pectate lyase 20 (At5g48900), Putative pectate lyase 2 (At1g11920), Probable pectate lyase 6 (At2g02720), Probable pectate lyase 9 (At3g24230), Probable pectate lyase 15 (At4g13710), Probable pectate lyase 4 (At1g30350), Putative pectate lyase 11 (At3g27400), Probable pectate lyase 12 (At3g53190), Probable pectate lyase 7 (At3g01270), Probable pectate lyase 8 (At3g07010), Probable pectate lyase 10 (At3g24670), Probable pectate lyase 19 (At5g15110), Pectate lyase (At3g55140), Pectate lyase, Pectate lyase (At5g09280), Pectate lyase (F11F8_12), Pectate lyase (AXX17_At3g00310), Pectate lyase (At3g27400), Pectate lyase (AXX17_At4g25610), Pectate lyase (AXX17_At1g61710), Pectate lyase, Pectate lyase (AXX17_At5g14600), Pectate lyase (AXX17_At1g30780), Pectate lyase (AXX17_At3g47590), Pectate lyase (AXX17_At3g49720), Pectate lyase (AXX17_At1g04020), Pectate lyase (At3g01270), Pectate lyase (At3g07010), Pectate lyase (AXX17_At5g08800), Pectate lyase (At3g01270), Pectate lyase (T26I12.20), Pectate lyase (AXX17_At3g09180), Pectate lyase (AXX17_At1g15010), Pectate lyase (AXX17_At5g47570), Pectate lyase (AXX17_At3g06910), Pectate lyase, Pectate lyase (AXX17_At5g03700), Pectate lyase (AXX17_At3g26200), Pectate lyase (AXX17_At4g25600), Pectate lyase (AXX17_At4g15660), Pectate lyase (At3g07010), Pectate lyase, Pectate lyase (At3g53190), Pectate lyase (AXX17_At3g49450), Pectate lyase (AXX17_At4g28670), Pectate lyase, Pectate lyase (AXX17_At2g01680), Pectate lyase (At4g13210), Pectate lyase (AXX17_At1g12300), Pectate lyase (At3g09540), Pectate lyase (At4g13710), Pectate lyase (At5g04310), Pectate lyase (AXX17_At4g14900), Pectate lyase (AXX17_At3g29900), Pectate lyase (AXX17_At5g54880), Pectate lyase (At3g55140), Pectate lyase (At3g07010), Pectate lyase (AXX17_At3g26720), Pectate lyase (AXX17_At5g62760), Pectate lyase (At1g14420), Pectate lyase (At5g04310)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway pectin degradation, which is itself part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-dehydro-3-deoxy-D-gluconate from pectin, the pathway pectin degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei551PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAspartyl esteraseUniRule annotationSAAS annotation, Hydrolase
Biological processCell wall biogenesis/degradationUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00545;UER00823

Names & Taxonomyi

Protein namesi
Recommended name:
PectinesteraseUniRule annotation (EC:3.1.1.11UniRule annotation)
Gene namesi
Ordered Locus Names:At4g15980Imported
ORF Names:Dl4030cImported, FCAALL.248Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell wallUniRule annotation, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32UniRule annotationAdd BLAST32
ChainiPRO_501000189833 – 711PectinesteraseUniRule annotationAdd BLAST679

Expressioni

Gene expression databases

ExpressionAtlasiA0A1P8B5T5 differential

Structurei

3D structure databases

SMRiA0A1P8B5T5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 205PMEIInterPro annotationAdd BLAST153

Sequence similaritiesi

In the C-terminal section; belongs to the pectinesterase family.SAAS annotation
In the N-terminal section; belongs to the PMEI family.SAAS annotation

Keywords - Domaini

SignalUniRule annotation

Family and domain databases

Gene3Di1.20.140.40, 1 hit
2.160.20.10, 1 hit
InterProiView protein in InterPro
IPR035513 Invertase/methylesterase_inhib
IPR012334 Pectin_lyas_fold
IPR011050 Pectin_lyase_fold/virulence
IPR033131 Pectinesterase_Asp_AS
IPR000070 Pectinesterase_cat
IPR006501 Pectinesterase_inhib_dom
IPR018040 Pectinesterase_Tyr_AS
PfamiView protein in Pfam
PF01095 Pectinesterase, 1 hit
PF04043 PMEI, 1 hit
SMARTiView protein in SMART
SM00856 PMEI, 1 hit
SUPFAMiSSF101148 SSF101148, 1 hit
SSF51126 SSF51126, 1 hit
TIGRFAMsiTIGR01614 PME_inhib, 1 hit
PROSITEiView protein in PROSITE
PS00800 PECTINESTERASE_1, 1 hit
PS00503 PECTINESTERASE_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

A0A1P8B5T5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWNGWNYSSK MNKYVLLGVT ALIMAMVICV EANDGNSPSR KMEEVHRESK
60 70 80 90 100
LMITKTTVSI ICASTDYKQD CTTSLATVRS PDPRNLIRSA FDLAIISIRS
110 120 130 140 150
GIDRGMIDLK SRADADMHTR EALNTCRELM DDAIDDLRKT RDKFRGFLFT
160 170 180 190 200
RLSDFVEDLC VWLSGSITYQ QTCIDGFEGI DSEAAVMMER VMRKGQHLTS
210 220 230 240 250
NGLAIAANLD KLLKAFRIPF PFLRSRRGRL GILGSGSSRD ESVGSSQDSP
260 270 280 290 300
PNEDSSDDSP STVDSSENQP VDSSSENQSS DSSNNRPLDS SKNQQMESSE
310 320 330 340 350
DTPKKSAFSG NQPLDDSSDK LPQKSTSSEN QPLDSSENPP QKSTSSENRP
360 370 380 390 400
LDPLRKLNPL NKLDSLKDRH LSEEGEFPPW VTPHSRRLLA RRPRNNGIKA
410 420 430 440 450
NVVVAKDGSG KCKTIAQALA MVPMKNTKKF VIHIKEGVYK EKVEVTKKML
460 470 480 490 500
HVMFVGDGPT KTVITGDIAF LPDQVGTYRT ASVAVNGDYF MAKDIGFENT
510 520 530 540 550
AGAARHQAVA LRVSADFAVF FNCHMNGYQD TLYVHTHRQF YRNCRVSGTI
560 570 580 590 600
DFVFGDAKAV FQNCEFVIRR PMEHQQCIVT AQGRKDRRET TGIVIHNSRI
610 620 630 640 650
TGDASYLPVK AKNRAFLGRP WKEFSRTIIM NTEIDDVIDP EGWLKWNETF
660 670 680 690 700
ALNTLFYTEY RNRGRGSGQG RRVRWRGIKR ISDRAAREFA PGNFLRGNTW
710
IPQTRIPYNA N
Length:711
Mass (Da):79,827
Last modified:April 12, 2017 - v1
Checksum:i293D9B2E70812031
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O23447PME43_ARATH
Putative pectinesterase/pectinester...
PME43 ARATH43, At4g15980, dl4030c, FCAALL.248
701Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002687 Genomic DNA Translation: ANM66956.1
RefSeqiNP_001328819.1, NM_001341080.1

Genome annotation databases

EnsemblPlantsiAT4G15980.2; AT4G15980.2; AT4G15980
GeneIDi827282
GrameneiAT4G15980.2; AT4G15980.2; AT4G15980

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002687 Genomic DNA Translation: ANM66956.1
RefSeqiNP_001328819.1, NM_001341080.1

3D structure databases

SMRiA0A1P8B5T5
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G15980.2; AT4G15980.2; AT4G15980
GeneIDi827282
GrameneiAT4G15980.2; AT4G15980.2; AT4G15980

Enzyme and pathway databases

UniPathwayi
UPA00545;UER00823

Gene expression databases

ExpressionAtlasiA0A1P8B5T5 differential

Family and domain databases

Gene3Di1.20.140.40, 1 hit
2.160.20.10, 1 hit
InterProiView protein in InterPro
IPR035513 Invertase/methylesterase_inhib
IPR012334 Pectin_lyas_fold
IPR011050 Pectin_lyase_fold/virulence
IPR033131 Pectinesterase_Asp_AS
IPR000070 Pectinesterase_cat
IPR006501 Pectinesterase_inhib_dom
IPR018040 Pectinesterase_Tyr_AS
PfamiView protein in Pfam
PF01095 Pectinesterase, 1 hit
PF04043 PMEI, 1 hit
SMARTiView protein in SMART
SM00856 PMEI, 1 hit
SUPFAMiSSF101148 SSF101148, 1 hit
SSF51126 SSF51126, 1 hit
TIGRFAMsiTIGR01614 PME_inhib, 1 hit
PROSITEiView protein in PROSITE
PS00800 PECTINESTERASE_1, 1 hit
PS00503 PECTINESTERASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A1P8B5T5_ARATH
AccessioniPrimary (citable) accession number: A0A1P8B5T5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: May 23, 2018
This is version 10 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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