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UniProtKB - A0A1P0AYU5 (A0A1P0AYU5_HUMAN)
Protein
Sidoreflexin
Gene
SFXN3
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
GO - Molecular functioni
- ion transmembrane transporter activity Source: InterPro
GO - Biological processi
- amino acid transport Source: UniProtKB-KW
Keywordsi
Biological process | Amino-acid transportARBA annotation, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: SidoreflexinUniRule annotation |
Gene namesi | Name:SFXN3Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16087, SFXN3 |
VEuPathDBi | HostDB:ENSG00000107819 |
Subcellular locationi
Mitochondrion
- Mitochondrion membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Mitochondrion
- mitochondrial membrane Source: UniProtKB-SubCell
- mitochondrion Source: HPA
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 270 – 290 | HelicalUniRule annotationAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, MitochondrionUniRule annotationARBA annotationInteractioni
Binary interactionsi
A0A1P0AYU5
Protein-protein interaction databases
IntActi | A0A1P0AYU5, 17 interactors |
Structurei
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT01030000234641 |
OrthoDBi | 881974at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR004686, Mtc |
PANTHERi | PTHR11153, PTHR11153, 1 hit |
Pfami | View protein in Pfam PF03820, SFXNs, 1 hit |
TIGRFAMsi | TIGR00798, mtc, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
A0A1P0AYU5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MESKMGELPL DINIQEPRWD QSTFLGRARH FFTVTDPRNL LLSGAQLEAS
60 70 80 90 100
RNIVQNYRAG VVTPGITEDQ LWRAKYVYDS AFHPDTGEKV VLIGRMSAQV
110 120 130 140 150
PMNMTITGCM LTFYRKTPTV VFWQWVNQSF NAIVNYSNRS GDTPITVRQL
160 170 180 190 200
GTAYVSATTG AVATALGLKS LTKHLPPLVG RFVPFAAVAA ANCINIPLMR
210 220 230 240 250
QRELQVGIPV ADEAGQRLGY SVTAAKQGIF QVVISRICMA IPAMAIPPLI
260 270 280 290 300
MDTLEKKDFL KRRPWLGAPL QVGLVGFCLV FATPLCCALF PQKSSIHISN
310 320
LEPELRAQIH EQNPSVEVVY YNKGL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9BWM7 | SFXN3_HUMAN | Sideroflexin-3 | SFXN3 | 321 | Annotation score: | ||
S4R3N9 | S4R3N9_HUMAN | Sideroflexin-3 | SFXN3 | 177 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL133215 Genomic DNA No translation available. |
RefSeqi | NP_112233.2, NM_030971.3 |
Genome annotation databases
Ensembli | ENST00000224807; ENSP00000224807; ENSG00000107819 |
GeneIDi | 81855 |
KEGGi | hsa:81855 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL133215 Genomic DNA No translation available. |
RefSeqi | NP_112233.2, NM_030971.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | A0A1P0AYU5, 17 interactors |
Proteomic databases
MaxQBi | A0A1P0AYU5 |
PeptideAtlasi | A0A1P0AYU5 |
Protocols and materials databases
Antibodypediai | 2332, 144 antibodies from 25 providers |
DNASUi | 81855 |
Genome annotation databases
Ensembli | ENST00000224807; ENSP00000224807; ENSG00000107819 |
GeneIDi | 81855 |
KEGGi | hsa:81855 |
Organism-specific databases
CTDi | 81855 |
HGNCi | HGNC:16087, SFXN3 |
OpenTargetsi | ENSG00000107819 |
VEuPathDBi | HostDB:ENSG00000107819 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT01030000234641 |
OrthoDBi | 881974at2759 |
Miscellaneous databases
BioGRID-ORCSi | 81855, 4 hits in 1037 CRISPR screens |
ChiTaRSi | SFXN3, human |
GenomeRNAii | 81855 |
Gene expression databases
ExpressionAtlasi | A0A1P0AYU5, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR004686, Mtc |
PANTHERi | PTHR11153, PTHR11153, 1 hit |
Pfami | View protein in Pfam PF03820, SFXNs, 1 hit |
TIGRFAMsi | TIGR00798, mtc, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A1P0AYU5_HUMAN | |
Accessioni | A0A1P0AYU5Primary (citable) accession number: A0A1P0AYU5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 15, 2017 |
Last sequence update: | March 15, 2017 | |
Last modified: | January 19, 2022 | |
This is version 33 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |