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Protein

Pyruvate carboxylase

Gene

cfiB_1

Organism
Mycobacteroides abscessus subsp. abscessus
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

biotinUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei117ATPUniRule annotation1
Binding sitei200ATPUniRule annotation1
Binding sitei235ATPUniRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei292UniRule annotation1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi533Divalent metal cationUniRule annotation1
Binding sitei605SubstrateUniRule annotation1
Metal bindingi703Divalent metal cation; via carbamate groupUniRule annotation1
Metal bindingi732Divalent metal cationUniRule annotation1
Metal bindingi734Divalent metal cationUniRule annotation1
Binding sitei867SubstrateUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigaseUniRule annotationImported
LigandATP-bindingUniRule annotation, BiotinUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, PyruvateImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pyruvate carboxylaseUniRule annotation (EC:6.4.1.1UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cfiB_1Imported
Synonyms:cfiBImported, cfiB_3Imported
ORF Names:SAMEA2068975_00952Imported, SAMEA2070424_04961Imported, SAMEA2070599_03374Imported, SAMEA2071298_04977Imported, SAMEA2071560_02589Imported, SAMEA2145025_00728Imported, SAMEA2275726_05737Imported, SAMEA2275790_03061Imported, SAMEA2275861_03859Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacteroides abscessus subsp. abscessusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1185650 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteroidesMycobacteroides abscessus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000248551 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000184814 Componenti: Unassembled WGS sequence
  • UP000249599 Componenti: Unassembled WGS sequence
  • UP000249597 Componenti: Unassembled WGS sequence
  • UP000248755 Componenti: Unassembled WGS sequence
  • UP000184667 Componenti: Unassembled WGS sequence
  • UP000249750 Componenti: Unassembled WGS sequence
  • UP000249368 Componenti: Unassembled WGS sequence
  • UP000248947 Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 449Biotin carboxylationInterPro annotationAdd BLAST449
Domaini121 – 317ATP-graspInterPro annotationAdd BLAST197
Domaini524 – 793Pyruvate carboxyltransferaseInterPro annotationAdd BLAST270
Domaini1053 – 1127Lipoyl-bindingInterPro annotationAdd BLAST75

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili174 – 194Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013785 Aldolase_TIM
IPR011761 ATP-grasp
IPR005481 BC-like_N
IPR001882 Biotin_BS
IPR011764 Biotin_carboxylation_dom
IPR005482 Biotin_COase_C
IPR000089 Biotin_lipoyl
IPR003379 Carboxylase_cons_dom
IPR005479 CbamoylP_synth_lsu-like_ATP-bd
IPR016185 PreATP-grasp_dom_sf
IPR000891 PYR_CT
IPR005930 Pyruv_COase
IPR011054 Rudment_hybrid_motif
IPR011053 Single_hybrid_motif

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02785 Biotin_carb_C, 1 hit
PF00289 Biotin_carb_N, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF02786 CPSase_L_D2, 1 hit
PF00682 HMGL-like, 1 hit
PF02436 PYC_OADA, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001594 Pyruv_carbox, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00878 Biotin_carb_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51230 SSF51230, 1 hit
SSF51246 SSF51246, 1 hit
SSF52440 SSF52440, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01235 pyruv_carbox, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS50979 BC, 1 hit
PS00188 BIOTIN, 1 hit
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00867 CPSASE_2, 1 hit
PS50991 PYR_CT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1N2UKF5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFSKVLVANR GEIAIRAFRA AYELGAETVA VYPYEDRNSG HRLKADEAYQ
60 70 80 90 100
IGEKGHPVRA YLSVSEVVNA ARNAGADAIY PGYGFLSENP DLAAACAEAG
110 120 130 140 150
ITFVGPPADV LELTGNKARA IAAAREAGLP VLASSEPSAS VEELLTAAES
160 170 180 190 200
MEFPVFVKAV AGGGGRGMRR VAERDQLREA IEAASREAES AFGDPTVFLE
210 220 230 240 250
QAVINPRHIE VQILADTAGN VIHLYERDCS VQRRHQKVIE LAPAPNLPPE
260 270 280 290 300
LREKICSDAV AFARHIGYSC AGTVEFLLDE RGHHVFIEMN PRIQVEHTVT
310 320 330 340 350
EEITDVDLVA SQLRIASGET LDDLGLHQDS ITPRGAALQC RITTEDPANG
360 370 380 390 400
FRPDTGRITA YRSPGGAGIR LDGGTTLGAE VGAHFDSMLV KLTCRGRDFQ
410 420 430 440 450
TAVARARRAV AEFRIRGVAT NIPFLQAVLD DPDFRAGHVT TSFIEERPQL
460 470 480 490 500
LTARSSADRG TKILNYLADV TVNKPHGAKP STVYPHDKLP PIDLSVPPPD
510 520 530 540 550
GSRQRLLALG PEGFAKALRE QKAVGLTDTT FRDAHQSLLA TRVRTTGLLA
560 570 580 590 600
VAPYVARLTP ELLSIEAWGG ATYDVALRFL KEDPWERLAD LREAVPNICL
610 620 630 640 650
QMLLRGRNTV GYTPYPETVT KAFIREASAT GVDIYRIFDA LNNIEAMRPA
660 670 680 690 700
IDAVREVGTS VAEVAMCYTG DLSNPGENLY TLDYYLKLAE QIVDAGAHVL
710 720 730 740 750
AIKDMAGLLR PPAAATLVTA LRSRFDLPVH VHTHDTAGGQ LATYLAAWQA
760 770 780 790 800
GADAVDGAAA PMAGTTSQPS LSAIVAAAAH SEYDTGVSLT SVCDLEPYWE
810 820 830 840 850
ALRKVYAPFE SGLPSPTGRV YTHEIPGGQL SNLRQQAIAL GLGDQFEEIE
860 870 880 890 900
ARYAAADRML GRLVKVTPSS KVVGDLALAL VGTGVSADEF ASDPGRFDIP
910 920 930 940 950
ESVIGFLRGE LGDPPGGWPE PFRTRALQGR GPARAEVALT ADDESQLDGD
960 970 980 990 1000
SATRRAALNR LLFPGPTKEF LAHREQYGDT SRLSANQFFY GLRYGEEHRV
1010 1020 1030 1040 1050
KLEKGVELLI GLEAISDADE HGMRTVMCIL NGQLRPVQVR DRSIESAVAS
1060 1070 1080 1090 1100
AEKADRANAD HVPAPFAGVV TLNVVSGQEV SAGETIGTIE AMKMEASITA
1110 1120
PKAGTVARVA LTETAQVEGG DLLVVIS
Length:1,127
Mass (Da):120,906
Last modified:March 15, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i339C748708B19D88
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FSAD01000015 Genomic DNA Translation: SHR31256.1
FSAB01000015 Genomic DNA Translation: SHR32177.1
FSEE01000003 Genomic DNA Translation: SHV85757.1
FSGQ01000009 Genomic DNA Translation: SHZ64712.1
FSQV01000008 Genomic DNA Translation: SIN41640.1
FVKM01000006 Genomic DNA Translation: SKQ79847.1
FVMP01000025 Genomic DNA Translation: SKU29536.1
FVPM01000006 Genomic DNA Translation: SKX43582.1
FVWC01000003 Genomic DNA Translation: SLF97602.1

NCBI Reference Sequences

More...
RefSeqi
WP_005087746.1, NZ_NQUY01000001.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FSAD01000015 Genomic DNA Translation: SHR31256.1
FSAB01000015 Genomic DNA Translation: SHR32177.1
FSEE01000003 Genomic DNA Translation: SHV85757.1
FSGQ01000009 Genomic DNA Translation: SHZ64712.1
FSQV01000008 Genomic DNA Translation: SIN41640.1
FVKM01000006 Genomic DNA Translation: SKQ79847.1
FVMP01000025 Genomic DNA Translation: SKU29536.1
FVPM01000006 Genomic DNA Translation: SKX43582.1
FVWC01000003 Genomic DNA Translation: SLF97602.1
RefSeqiWP_005087746.1, NZ_NQUY01000001.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR011761 ATP-grasp
IPR005481 BC-like_N
IPR001882 Biotin_BS
IPR011764 Biotin_carboxylation_dom
IPR005482 Biotin_COase_C
IPR000089 Biotin_lipoyl
IPR003379 Carboxylase_cons_dom
IPR005479 CbamoylP_synth_lsu-like_ATP-bd
IPR016185 PreATP-grasp_dom_sf
IPR000891 PYR_CT
IPR005930 Pyruv_COase
IPR011054 Rudment_hybrid_motif
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF02785 Biotin_carb_C, 1 hit
PF00289 Biotin_carb_N, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF02786 CPSase_L_D2, 1 hit
PF00682 HMGL-like, 1 hit
PF02436 PYC_OADA, 1 hit
PIRSFiPIRSF001594 Pyruv_carbox, 1 hit
SMARTiView protein in SMART
SM00878 Biotin_carb_C, 1 hit
SUPFAMiSSF51230 SSF51230, 1 hit
SSF51246 SSF51246, 1 hit
SSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01235 pyruv_carbox, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS50979 BC, 1 hit
PS00188 BIOTIN, 1 hit
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00867 CPSASE_2, 1 hit
PS50991 PYR_CT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1N2UKF5_9MYCO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1N2UKF5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 15, 2017
Last sequence update: March 15, 2017
Last modified: December 5, 2018
This is version 14 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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