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Protein

Phosphopantetheine adenylyltransferase

Gene

coaD

Organism
Thermocrinis minervae
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.UniRule annotationSAAS annotation

Catalytic activityi

ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotationSAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (SAMN05444391_1510)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (SAMN05444391_1510)
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9SubstrateUniRule annotation1
Binding sitei17ATPUniRule annotation1
Sitei17Transition state stabilizerUniRule annotation1
Binding sitei41SubstrateUniRule annotation1
Binding sitei73Substrate; via amide nitrogenUniRule annotation1
Binding sitei87SubstrateUniRule annotation1
Binding sitei98ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 10ATPUniRule annotation2
Nucleotide bindingi88 – 90ATPUniRule annotation3
Nucleotide bindingi122 – 128ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processCoenzyme A biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00241;UER00355

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphopantetheine adenylyltransferaseUniRule annotation (EC:2.7.7.3UniRule annotation)
Alternative name(s):
Dephospho-CoA pyrophosphorylaseUniRule annotation
Pantetheine-phosphate adenylyltransferaseUniRule annotation
Short name:
PPATUniRule annotation
Gene namesi
Name:coaDUniRule annotation
ORF Names:SAMN05444391_0541Imported
OrganismiThermocrinis minervaeImported
Taxonomic identifieri381751 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeThermocrinis
Proteomesi
  • UP000189810 Componenti: Chromosome i

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homohexamer.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 131CTP_transf_likeInterPro annotationAdd BLAST127

Sequence similaritiesi

Belongs to the bacterial CoaD family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd02163 PPAT, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00151 PPAT_bact, 1 hit
InterProiView protein in InterPro
IPR004821 Cyt_trans-like
IPR001980 PPAT
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR21342:SF1 PTHR21342:SF1, 1 hit
PfamiView protein in Pfam
PF01467 CTP_transf_like, 1 hit
PRINTSiPR01020 LPSBIOSNTHSS
TIGRFAMsiTIGR01510 coaD_prev_kdtB, 1 hit
TIGR00125 cyt_tran_rel, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1M6R7H5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVRVVYPGTF DPPHLGHLDI VKRSLRLFDE VLVAVAKNPQ KKTLFTLEER
60 70 80 90 100
VDMFQKMVEG MERVSVEGFE CLLVDFMKQK NIWVIVRGVR LFTDFEYELL
110 120 130 140 150
IAMNNHRLMG VETVFMMPSQ EYIHISSSIV KDIASYCGNL ENLVHPYVGK

KLREKFGCY
Length:159
Mass (Da):18,522
Last modified:March 15, 2017 - v1
Checksum:iF753573DE97F12D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT670846 Genomic DNA Translation: SHK28431.1

Similar proteinsi

Entry informationi

Entry nameiA0A1M6R7H5_9AQUI
AccessioniPrimary (citable) accession number: A0A1M6R7H5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 15, 2017
Last sequence update: March 15, 2017
Last modified: October 25, 2017
This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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