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Protein

Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)

Gene

uppS

Organism
Methanothermobacter wolfeii (Methanobacterium wolfei)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

Geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tritrans,heptacis-undecaprenyl diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei33UniRule annotation1
Metal bindingi33MagnesiumUniRule annotation1
Binding sitei51SubstrateUniRule annotation1
Active sitei82Proton acceptorUniRule annotation1
Binding sitei83SubstrateUniRule annotation1
Binding sitei85SubstrateUniRule annotation1
Binding sitei204SubstrateUniRule annotation1
Metal bindingi223MagnesiumUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionTransferaseUniRule annotationImported
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)UniRule annotation (EC:2.5.1.89UniRule annotation)
Alternative name(s):
Undecaprenyl diphosphate synthaseUniRule annotation
Short name:
UDSUniRule annotation
Undecaprenyl pyrophosphate synthaseUniRule annotation
Short name:
UPP synthaseUniRule annotation
Gene namesi
Name:uppSUniRule annotationImported
ORF Names:MWSIV6_0644Imported
OrganismiMethanothermobacter wolfeii (Methanobacterium wolfei)Imported
Taxonomic identifieri145261 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000184850 Componenti: Chromosome i

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni34 – 37Substrate bindingUniRule annotation4
Regioni79 – 81Substrate bindingUniRule annotation3
Regioni210 – 212Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

KOiK15888

Family and domain databases

CDDicd00475 Cis_IPPS, 1 hit
Gene3Di3.40.1180.10, 1 hit
HAMAPiMF_01139 ISPT, 1 hit
InterProiView protein in InterPro
IPR001441 UPP_synth-like
IPR018520 UPP_synth-like_CS
IPR036424 UPP_synth-like_sf
PANTHERiPTHR10291 PTHR10291, 1 hit
PfamiView protein in Pfam
PF01255 Prenyltransf, 1 hit
SUPFAMiSSF64005 SSF64005, 1 hit
TIGRFAMsiTIGR00055 uppS, 1 hit
PROSITEiView protein in PROSITE
PS01066 UPP_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1M4MRB4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPLKPIYRL YEWYISRNLK KEKMPRHIAI IMDGNRRYSR IHGSFDPIEG
60 70 80 90 100
HKKGIETLEK VLDWCVDLCI EIVTAYAFST ENFKRPEREV KGLMKLFKEN
110 120 130 140 150
FEAITSNEKI HKNRVRVKAV GKLELLPEDV RRAIEVAEKS TEQYSDRLVN
160 170 180 190 200
IAIGYDGRQE IVDAARKIAE DVKAGKIEPE DIDEDLINRN LYTAGLEDPH
210 220 230 240 250
LIIRTSGEER LSGFLLWQSS YSELYFCDSL WPELRKVDFL RAIRSYQERE

RRFGT
Length:255
Mass (Da):29,944
Last modified:March 15, 2017 - v1
Checksum:i0D663D01B787C6F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT608329 Genomic DNA Translation: SCM56681.1
RefSeqiWP_074359726.1, NZ_LT608329.1

Genome annotation databases

GeneIDi30670244
KEGGimwo:MWSIV6_0644

Entry informationi

Entry nameiA0A1M4MRB4_METWO
AccessioniPrimary (citable) accession number: A0A1M4MRB4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 15, 2017
Last sequence update: March 15, 2017
Last modified: November 22, 2017
This is version 9 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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