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Entry version 21 (02 Jun 2021)
Sequence version 1 (15 Mar 2017)
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Protein

Malformin synthetase mlfA

Gene

mlfA

Organism
Aspergillus luchuensis (strain CBS 106.47)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of malformins, cyclic pentapeptides with a disulfide bond between 2 consecutive cysteins, that show potential anti-tumor as well as antimalarial and antitrypanosomal properties (PubMed:30560908).

The nonribosomal peptide synthetase mlfA is responsible of the formation of the cyclic pentapeptide (Probable). The malformin biosynthesis clusters in malformin-producing fungi also contain enzymes involved in the formation of the disulfide bond between the two consecutive cysteins within malformins, in addition to additionnal tailoring enzymes such as methyltransferases or oxidoreductases. They are also composed of up to 4 major facilitator superfamily transporters, and transcription factors probably involved in the regulation of the expression of those clusters (Probable).

1 Publication1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Secondary metabolite biosynthesis

This protein is involved in Secondary metabolite biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in Secondary metabolite biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Malformin synthetase mlfA1 Publication (EC:6.3.2.-1 Publication)
Alternative name(s):
Malformin biosynthesis cluster protein A1 Publication
Nonribosomal peptide synthetase mlfA1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mlfA1 Publication
ORF Names:ASPFODRAFT_65064
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAspergillus luchuensis (strain CBS 106.47)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1137211 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000184063 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

Malformins show anti-tumor properties against human colorectal and prostate cancer cells by the inhibition of proliferation and induction of apoptosis through the activation of the p38 signaling pathway (PubMed:26540166, PubMed:26645406, PubMed:28713983). Malformin C has also been shown to exhibit potent antimalarial and antitrypanosomal properties (PubMed:19876076).4 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004464341 – 5082Malformin synthetase mlfAAdd BLAST5082

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei783O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei1883O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3061O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei4597O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A1M3T4K3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini749 – 822Carrier 1PROSITE-ProRule annotationAdd BLAST74
Domaini1846 – 1923Carrier 2PROSITE-ProRule annotationAdd BLAST78
Domaini3024 – 3100Carrier 3PROSITE-ProRule annotationAdd BLAST77
Domaini4560 – 4636Carrier 4PROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni225 – 616Adenylation 1Sequence analysisAdd BLAST392
Regioni860 – 1291Condensation 1Sequence analysisAdd BLAST432
Regioni1319 – 1708Adenylation 2Sequence analysisAdd BLAST390
Regioni1924 – 1953DisorderedSequence analysisAdd BLAST30
Regioni1986 – 2012DisorderedSequence analysisAdd BLAST27
Regioni2058 – 2473Condensation 2Sequence analysisAdd BLAST416
Regioni2496 – 2888Adenylation 3Sequence analysisAdd BLAST393
Regioni3117 – 3582Condensation 3Sequence analysisAdd BLAST466
Regioni3603 – 4022Condensation 4Sequence analysisAdd BLAST420
Regioni4047 – 4426Adenylation 4Sequence analysisAdd BLAST380
Regioni4673 – 5000Condensation 5Sequence analysisAdd BLAST328

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1924 – 1947Polar residuesSequence analysisAdd BLAST24
Compositional biasi1986 – 2008Polar residuesSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module. Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product. Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, epimerase (E) domains (responsible for L- to D- amino acid conversion) are present within the NRP synthetase. MlfA has the following architecture: A-T-C-A-T-C-A-T-C-C-A-T-C, with the functions of the five condensation domains during malformin biosynthesis being DL-joining (epimerizing subtype), LL-joining, epimerization, DL-joining and cyclizing domain, respectively.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRP synthase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
4243at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 4 hits
3.30.559.10, 5 hits
3.40.50.12780, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501, AMP-binding, 4 hits
PF00668, Condensation, 5 hits
PF00550, PP-binding, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823, PKS_PP, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 4 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733, AA-adenyl-dom, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455, AMP_BINDING, 3 hits
PS50075, CARRIER, 4 hits
PS00012, PHOSPHOPANTETHEINE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1M3T4K3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRFSCIFPT LTDGYVPNPD HTRAAGRRTY RIDLSGWKAP GSETESLILA
60 70 80 90 100
AWGLVLSSYV GTDEVAFYVV PTTGPDTTAL AELKVEGDMP RQSLTYAAHQ
110 120 130 140 150
LLHPGLVGAG QVSGETANTI ITFANDIESL FVTQTEESFL SLHVYRDEQG
160 170 180 190 200
HISLSLTYYL SLLTDAQAAN VGTAMAQALA EVGTCDNDKL VKDLSLMSPA
210 220 230 240 250
HLEHIWRFNA DVPGIWEECF HDVIERHAAN RPHSLAVDAW DTKLTYTDLV
260 270 280 290 300
REARLLAAYL QRRGVGPGSV VPISFERSGA ALVAMLAVSK AGGAFVSVPP
310 320 330 340 350
NLPAGRVDAI LEVIEAPFVV TWTKYESFWA ERLPTLPIDN YPKPAADATV
360 370 380 390 400
EALGKPEDLF YVIFTSGSTG RPKGCMLSHT NWLNGALRNA PSWKYGPESR
410 420 430 440 450
VLQMLSHTFD MSLLEICTSL GSGSCVCVPR PEEIETSISD AINRWQVNHV
460 470 480 490 500
IMTPSLARAL RPDDVPGLKT MCLGGEAFPK EIVTMWSERI NLWQFYGPSE
510 520 530 540 550
CSINSSSWPI TRPDADPLNI GPPNSAACWV VDVHDYNKLV PVGAIGELLV
560 570 580 590 600
SGPIVGMGYL KNPVKTAEAF LEEVGFVAKD DPQFGGFRFY RTGDLVRWNS
610 620 630 640 650
DGTITFCGRA DTQVKLNGQR LELAEVEYQL GLEAGVQYAI AMAPQAGLCK
660 670 680 690 700
NNLIAILTVK GTSTGTQDTA ADEIPLLDRR DPIVQETVKK LRSQLQHALP
710 720 730 740 750
RYMVPTIWAF VGRMPMSASG KIDRRMSQET FDAITGRSLE AEEHAFGLSR
760 770 780 790 800
LEQKIQLAWA EALGLSAAEV GLQQPFVALG GDSIKALDAV ARCRARQIKI
810 820 830 840 850
SMVHILSCEG VREAASLAEV QETPAQQVAE MAVDYSNLWT RLSNDYDLDK
860 870 880 890 900
LGVTQVEEVE NVFPCTTMQE GMFLGQIRRP GAYHMRFFHR VQLKGGCLPT
910 920 930 940 950
VERIQQAWAS LVERHPSLRT VFVDDLSPEA IYHSIVLRSV PMEVRMREVP
960 970 980 990 1000
RDLSAEAALA IFTEELVPFR ANAPLHRMLL LTCRGRVPYL MLEISHVIMD
1010 1020 1030 1040 1050
GYALSVFRRE FIRACSSSAP LPRGPDYRMF ANYHRTRQTD DSARYWTDYL
1060 1070 1080 1090 1100
ADCVPCHIPT HAVSAPSDGP PEWPRTLQRR DFGFENSAAF LQRCKERQVT
1110 1120 1130 1140 1150
LACAIRAAWA LVLRAYTQSE DVCFGYVSSG RNVPVPEVET IFGLCLSMQV
1160 1170 1180 1190 1200
CRARLSEAST IASLARKIQE DYVASLPFQH YPLAEAQRGL KQTHGQGLFN
1210 1220 1230 1240 1250
TAISMEWVPP SAEDEDALLD LEEIREQDDP TEYDIAISVD VHEGHIKLGF
1260 1270 1280 1290 1300
LYWPDLTDFE INHLAEALHG AMNCFASHPD EALNTLSLLQ ASDVCSALSD
1310 1320 1330 1340 1350
GPTLLPLEAV RGNVVSMIDR WVTRQPEGAA IDGWDGSMSY KELHEQSSWV
1360 1370 1380 1390 1400
ARNLLHQGVR LGDRVLVCAD RSSRTVATIL GIVRAGCVLV LSNPTDPEKR
1410 1420 1430 1440 1450
LQWLAKKCNA SLVVADPTYE ERLATADAHV LSTTSVCAPA AWDYEFPALD
1460 1470 1480 1490 1500
EHDLISILFT SGSTGTPKGI LMEHGALATS VFLGHGRTLR FSRHTRMLHF
1510 1520 1530 1540 1550
ASLTFDAALA EIFTTLAHGG CICVPCEEDR LSDVPGCISR FAVNTAMLTP
1560 1570 1580 1590 1600
SVGRLLDPGA LPTLQTLIMV GEPMSRLDVE RFAPVLDLYN GAGPTETSIM
1610 1620 1630 1640 1650
VTIAGPMKPT DEPVNLGYAV AGVRLWVTEA ENPNRLAPLG AVGELIVEGR
1660 1670 1680 1690 1700
LVTSGYLDDQ ARTQEAFLPT LPWLPSQHAL YRTGDLVRYV DDGSLRYMGR
1710 1720 1730 1740 1750
KDTQVKLRGQ RIELQEVEYH LRKSLQQAQI VVEMVVPAGK MRAQASLVAF
1760 1770 1780 1790 1800
VSGLTAADVE SSSACNLEGT IPISQIVLPK SAFQALEEVL PRHMIPSVYY
1810 1820 1830 1840 1850
ALDTIPLSVN GKADRRRLRE MGSLLLASSA AHKNNIEGMS KSVKWTPTLE
1860 1870 1880 1890 1900
LERTLLGLWA ATLGLEAETI HGDDSFFELG GDSVSAMKLV ATARDKYKLS
1910 1920 1930 1940 1950
LSVPQMFRYP TVCQLAAEVG EPAGQSASSA SSTTEEGFTF STPDDSSTND
1960 1970 1980 1990 2000
GVDDDFLQLA TAQLAQLAQE KGKKVDIAAL LKQLQGGSSS NKTPSVSSSS
2010 2020 2030 2040 2050
SSSSSSKRKK NAAKAESLAE AAAPIPVQFS LLDGGADALD KVRAQAVEHC
2060 2070 2080 2090 2100
KITHEDIEDI YPATALQEGM MALTARTPGV YTTTLTGDLS EQVDIARLQY
2110 2120 2130 2140 2150
AWGKAAEAHP ILRTRIILTD NNTAVQVVQR AKGLPWDTYS LREDNVLPDL
2160 2170 2180 2190 2200
TSNMTSGSPL LRLAVVHRQS QPRMLLVAIH HALYDGWSMP LLKQAVEDAY
2210 2220 2230 2240 2250
HGRDLRPQPF TPFIKHLIAG KPAAQDFWTT HLDNFVGGVF PKLPSIYHQI
2260 2270 2280 2290 2300
QPTERRTRSM TLPTAAPKAQ YTMATKIQAA WAVTVSRYVE ANDIVFGTVS
2310 2320 2330 2340 2350
TGRSAPVPAI DRMVGPTVTT VPVRISLGGQ ADRVLSLLQR VQEDSWNKLD
2360 2370 2380 2390 2400
HEHLGLQHIR RLGESAAAAC NFQTLLVIQP REQPDTKYRS TLLSGLQDVA
2410 2420 2430 2440 2450
ELEGVDTYPL MLVCEPDGAS LNLTAVFDRA VLDGATLDRM LAHWELVLTQ
2460 2470 2480 2490 2500
MWNEPNMAVI DIDAVSCSDK ETLMRWNTGE TITEGCAHNA VCEWSRRTPH
2510 2520 2530 2540 2550
APAVCAWDGE WTYKELERYS SLIASQISAH GLSSGDFVAL YHEKSRWTAA
2560 2570 2580 2590 2600
GILAVFKAGA ILITLDPAHP TDRIKDILDQ ARPRLILTSQ SLLDVARNLD
2610 2620 2630 2640 2650
TPVLSVQFAA SQPLPEEWSS LPTICPTLAA YAPFTSGSTG RPKGIPLDHR
2660 2670 2680 2690 2700
GLAASTASIA RSCLLRPASR VLHFASFAFD ASMMEHLIAW HAGGCLCIPD
2710 2720 2730 2740 2750
ETARQTDLAK CIRDFNVTWA FLTPSCLRLI TPDDVPSLQA LGLGGESMTS
2760 2770 2780 2790 2800
EDITIWSPRL RQIVQLYGPA ECCIVAALTE VTKPSENRLI GRPNACRCWV
2810 2820 2830 2840 2850
VDPQNPDRLA PIGAVGELLI EGITVGRGYI NDPDRTTPAF IRPPKWLQTL
2860 2870 2880 2890 2900
YPDDQEPKRL YRTGDLVRYA GVDGKLAFIG RRDGQLKLHG QRIELADVEA
2910 2920 2930 2940 2950
HLRSLIPGMQ KMVVEMVHSA DNQNPFLAAF LEEISTSQKP KEREIGLLHP
2960 2970 2980 2990 3000
SQSQCALDVK AIDSALSRTV PQYMIPSMYL HISRLPLSAS GKLDRRHLRE
3010 3020 3030 3040 3050
MVAELPRQSL NEYAAGSGLG VPDRPVTSQE HEMQAIWARV LSLDPNTFGV
3060 3070 3080 3090 3100
NDDFFRIGGD SISGMQVSTK CNAAGIHITS ADLFRHRTIE QLICHLNTIR
3110 3120 3130 3140 3150
TTDSASVLLP TEPVNEWVAL APIQHLFFEV APEGPNHFNQ SLLLRTSRRV
3160 3170 3180 3190 3200
SVEELAGGLD VLIGRHSMLR ARFCRKDSGQ WFQQVKSLDS EPASAFYRLA
3210 3220 3230 3240 3250
AHNHITRESL RTLFTAAQMA LSIEDGPLLT VDLVELEDGS QLVYLAAHHL
3260 3270 3280 3290 3300
IIDLVSWRIL HGDLEEYLQT GSLSSATGSV PFLTWTQLQA EYSAEHLTPA
3310 3320 3330 3340 3350
RALPGFQEAN DDFDFMRYWG ISSESNTFGQ TSTSRFALDR TVTDILFGSA
3360 3370 3380 3390 3400
NKVMDTRPVE ILEAALWYSC NQALPDHPGP SIYVEGHGRE PWTDSIDVSG
3410 3420 3430 3440 3450
TVGWFTIMSP LVSTPWHHLS RKSMRDFVDV LSYIKDQRRR IPANGWAYFT
3460 3470 3480 3490 3500
SRYLNDEGRV AYGRTKPVME VLFNYMGQYQ EMKREDAILQ LAGDDIQSGT
3510 3520 3530 3540 3550
GASDIAGNVP RFSLIDVTAF TANGCLTFEF TFPQLIQQDA RLEQCIKECE
3560 3570 3580 3590 3600
HTLVAAASSL SAEGPRKTLT DFPLMSALTY DQLSQCLNHT LPSMGLRAQD
3610 3620 3630 3640 3650
VWNIYPCSPV QRGMLLAQLR DRQAYQQRFK FQVMSRGPTE QLSLEKVKDA
3660 3670 3680 3690 3700
WTEVINRHDI LRTLLLPVSD HSHFDQVVMV PGSLQHLVRG DAMDANPTEG
3710 3720 3730 3740 3750
LPHTINITSD STGAIICEWN VSHALVDAMS IAFIQREVNQ ALEGSLGQHQ
3760 3770 3780 3790 3800
NLPQYVEYIK WLTLQDNTEA QAYWQNHLNG VEPCLFPKLT SSPDKVNPEA
3810 3820 3830 3840 3850
TISAIRATWS RDVRMDELCH KHAITLTNLF HIVWAIVLGA YVGTDEVCFG
3860 3870 3880 3890 3900
YTALGRDVPV HRVETLVGPL VNVLATTVRH QEDETILNAL LTHQAHLTNS
3910 3920 3930 3940 3950
LQHQHYALAD VYASLGLVGS QLFNTIVSLQ DTSHFDAPDE QRTRLEMLPA
3960 3970 3980 3990 4000
NDVSEYDVAL NIGVDKSTIQ LVCSYQTVSL SAEQADALLR TAFHVLDEIL
4010 4020 4030 4040 4050
RDPTQRFCEL EVISPKCKEH LVKWNAGMLA PTHEYIHEKI QGQCRIHNSR
4060 4070 4080 4090 4100
QAVFDDLSSR LAARLIRMGV TSEDIIPIYS PKSRWMVIAI LGVLKAGAAF
4110 4120 4130 4140 4150
TLLEISHPMA RLRVICNQIK APMLIAPASH AVPAANLAPI LVVLDNITSL
4160 4170 4180 4190 4200
AEERPVSLPA VDIPPAREAL AYLIFTSGST GNPKGVMVTH QNLCSNASII
4210 4220 4230 4240 4250
TTSVNMTSDS RVLQFASHAF DGCLWEILGA LLAGACLIIP SESENKEDLT
4260 4270 4280 4290 4300
GCIERMGVTW AFLTPSVARI LKPETLPSLC NLVLGGEPIA ASDLEMWRGH
4310 4320 4330 4340 4350
VQVVCAYGPT ETTILASTTS PSTFPRDGKD IGTPTSSSLW IVDTRNYQTL
4360 4370 4380 4390 4400
VPLGATGELL IEGPNVSQGY LGDPEKTNDA FPDAPRWLSQ LRKSPTRLYR
4410 4420 4430 4440 4450
TGDLVRFDTS TGTIRFVGRK DNQIKFHGQR IELGEIEYHA QFAFSSASTV
4460 4470 4480 4490 4500
IVDLITPEQP RQPYIVAFVH QLDAANETTD TNDTLLLPSS EVFRADALAA
4510 4520 4530 4540 4550
QNKMHKRLPH YMVPAVFLPL HRLPLSVTGK ADRKRLRQCA LALSSPELSA
4560 4570 4580 4590 4600
YRATASTKRM PSTAAERKMQ ELVATVLGRD PTEIGMDDSF FYLGGDSVQA
4610 4620 4630 4640 4650
MRLVAEGRQQ GLTLSLRAIF DSPCLGDLSD QAKSLIEDNQ RASTASRGNL
4660 4670 4680 4690 4700
RYDCDRIDKI VVTNSLNKAD VVDVLPTTSF QRHWLDAQLK SYIVVDIPGP
4710 4720 4730 4740 4750
IDPARLLRAM HRVVEAHPIL RVSFVPYETT TVQVILRTAV AITNVDLSTA
4760 4770 4780 4790 4800
TVEELCRRDV DAQMAPGVPY LRVIIATQDK AGHKLIMRLS HAQYDAVSLS
4810 4820 4830 4840 4850
LLMNDLSHAY ANDTHPLPSS HFPRFNDYIT YQQAQRADLT ATTFWRHLLQ
4860 4870 4880 4890 4900
DVPLTHLNLQ PAESSASNGT PITLSRDIDI AVFPSLPSDI TIATMVKAAW
4910 4920 4930 4940 4950
SLALAQKTNS LAVIFGQVVH GRAIALPGVE GIVGPCANIT PVVARLGLET
4960 4970 4980 4990 5000
TGLELMQALQ DQHHSAMSYE SVDLDDALAY ANDSQAGRKG LQTIVQHQNN
5010 5020 5030 5040 5050
VMVDDMELSL GEVKCGVDFR AVDHLPKEVW VYSSVDEKRP GMLEVKIMSS
5060 5070 5080
TLVLGEEFAE ELMGLLVEKI VGLLRHPESV CV
Length:5,082
Mass (Da):559,619
Last modified:March 15, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9EDF479B8051EC4C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KV878250 Genomic DNA Translation: OJZ81665.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
OJZ81665; OJZ81665; ASPFODRAFT_65064

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KV878250 Genomic DNA Translation: OJZ81665.1

3D structure databases

SMRiA0A1M3T4K3
ModBaseiSearch...

Genome annotation databases

EnsemblFungiiOJZ81665; OJZ81665; ASPFODRAFT_65064

Phylogenomic databases

OrthoDBi4243at2759

Family and domain databases

Gene3Di1.10.1200.10, 4 hits
3.30.559.10, 5 hits
3.40.50.12780, 4 hits
InterProiView protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501, AMP-binding, 4 hits
PF00668, Condensation, 5 hits
PF00550, PP-binding, 4 hits
SMARTiView protein in SMART
SM00823, PKS_PP, 3 hits
SUPFAMiSSF47336, SSF47336, 4 hits
TIGRFAMsiTIGR01733, AA-adenyl-dom, 4 hits
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 3 hits
PS50075, CARRIER, 4 hits
PS00012, PHOSPHOPANTETHEINE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMLFA_ASPLC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1M3T4K3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 10, 2019
Last sequence update: March 15, 2017
Last modified: June 2, 2021
This is version 21 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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