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Entry version 17 (03 Jul 2019)
Sequence version 1 (15 Mar 2017)
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Protein

Malformin synthetase mlfA

Gene

mlfA

Organism
Aspergillus brasiliensis (strain CBS 101740 / IMI 381727 / IBT 21946)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of malformins, cyclic pentapeptides with a disulfide bond between 2 consecutive cysteins, that show potential anti-tumor as well as antimalarial and antitrypanosomal properties (PubMed:30560908). The nonribosomal peptide synthetase mlfA is responsible of the formation of the cyclic pentapeptide. MlfA probably acts iteratively on one amino acid and possesses multiple amino acid specificities since it is involved in the biosynthesis of multiple malformins, including malformin C and malformin A2. Malformin C corresponds to a cyclo[D-Cys-D-Cys-Val-D-Leu-Val] pentapeptide whereas malformin A2 corresponds to a cyclo[D-Cys-D-Cys-Val-D-Leu-Ile] pentapeptide (PubMed:30560908). The malformin biosynthesis clusters in malformin-producing fungi also contain enzymes involved in the formation of the disulfide bond between the two consecutive cysteins within malformins, in addition to additionnal tailoring enzymes such as methyltransferases or oxidoreductases. They are also composed of up to 4 major facilitator superfamily transporters, and transcription factors probably involved in the regulation of the expression of those clusters (Probable).1 Publication1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Secondary metabolite biosynthesis

This protein is involved in Secondary metabolite biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in Secondary metabolite biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Malformin synthetase mlfA1 Publication (EC:6.3.2.-1 Publication)
Alternative name(s):
Malformin biosynthesis cluster protein A1 Publication
Nonribosomal peptide synthetase mlfA1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mlfA1 Publication
ORF Names:ASPBRDRAFT_34020
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAspergillus brasiliensis (strain CBS 101740 / IMI 381727 / IBT 21946)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri767769 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000184499 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

Malformins show anti-tumor properties against human colorectal and prostate cancer cells by the inhibition of proliferation and induction of apoptosis through the activation of the p38 signaling pathway (PubMed:26540166, PubMed:26645406, PubMed:28713983). Malformin C has also been shown to exhibit potent antimalarial and antitrypanosomal properties (PubMed:19876076).4 Publications

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Leads to a total abolishment of malformin A2 and C production.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004464291 – 5112Malformin synthetase mlfAAdd BLAST5112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei791O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei1891O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3067O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei4630O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini757 – 830Carrier 1PROSITE-ProRule annotation1 PublicationAdd BLAST74
Domaini1854 – 1931Carrier 2PROSITE-ProRule annotation1 PublicationAdd BLAST78
Domaini3030 – 3106Carrier 3PROSITE-ProRule annotation1 PublicationAdd BLAST77
Domaini4593 – 4669Carrier 4PROSITE-ProRule annotation1 PublicationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni225 – 616Adenylation 1Sequence analysis1 PublicationAdd BLAST392
Regioni868 – 1299Condensation 1Sequence analysis1 PublicationAdd BLAST432
Regioni1327 – 1716Adenylation 2Sequence analysis1 PublicationAdd BLAST390
Regioni2064 – 2479Condensation 2Sequence analysis1 PublicationAdd BLAST416
Regioni2502 – 2894Adenylation 3Sequence analysis1 PublicationAdd BLAST393
Regioni3122 – 3586Condensation 3Sequence analysis1 PublicationAdd BLAST465
Regioni3607 – 4044Condensation 4Sequence analysis1 PublicationAdd BLAST438
Regioni4069 – 4459Adenylation 4Sequence analysis1 PublicationAdd BLAST391
Regioni4724 – 5106Condensation 5Sequence analysis1 PublicationAdd BLAST383

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module. Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product. Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, epimerase (E) domains (responsible for L- to D- amino acid conversion) are present within the NRP synthetase. MlfA has the following architecture: A-T-C-A-T-C-A-T-C-C-A-T-C, with the functions of the five condensation domains during malformin biosynthesis being DL-joining (epimerizing subtype), LL-joining, epimerization, DL-joining and cyclizing domain, respectively.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRP synthase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
4243at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 4 hits
3.30.559.10, 5 hits
3.40.50.12780, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071 AA_adenyl_domain
IPR036736 ACP-like_sf
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501 AMP-binding, 4 hits
PF00668 Condensation, 5 hits
PF00550 PP-binding, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823 PKS_PP, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336 SSF47336, 4 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733 AA-adenyl-dom, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455 AMP_BINDING, 3 hits
PS50075 CARRIER, 4 hits
PS00012 PHOSPHOPANTETHEINE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1L9U7P9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRFSCIFPT LTDGYVPNPD HTRAAGRRTY TIDLSGWNGS SGQAESYILA
60 70 80 90 100
AWGLVLSSYV GTDEVAFYVV PTTGPDTTAL AELKVEGDMS RLSLTDAAEQ
110 120 130 140 150
LLHPKHVGAG QISGETANTI ITFANDIESL FVTQTEESFL LLHVHRDEKG
160 170 180 190 200
HISLTLTYYL SLLTDAQAAN VCTAMSQALA VVTTDHPERL IKDLNLMSPT
210 220 230 240 250
HIDHIWKFNA NVPGPWEECF HDVVERHAAN RPHSLAVDAW DMKLTYAELV
260 270 280 290 300
REAHLLAAYL QQRGVRPGSV VPISFERSGA ALVAMLAVSK AGGAFVSVPP
310 320 330 340 350
NLPAGRLDAI LEVIEAPFVV TWSKYEAFWS ERLSTLPIDN YPKPSGDATV
360 370 380 390 400
ESLGKPDDLF YVIFTSGSTG RPKGCMLSHS NWLNGALRNA PSWKYGPESR
410 420 430 440 450
VLQMLSHTFD MSLLEICTSL GSGACVCVPC TEEIETSVSD AINRWQVNHV
460 470 480 490 500
IMTPSLARAL KPDDVPGLKT MCLGGEAFPK EIVTMWSERI NLWQFYGPSE
510 520 530 540 550
CSINSSSRPI TRPDADPLNI GPPNSAACWV VDAQDYNKLV PVGAIGELLV
560 570 580 590 600
SGPIVGMGYL KNPVKTAEAF LDQVGFVSKD DPQFGGFRFY RTGDHVRWNS
610 620 630 640 650
DGTITFCGRA DTQVKLNGQR LELAEVEYQL GLEDGVQYAI AMSPQTGRCK
660 670 680 690 700
NNLIAILTVK GTNCSNQRNA ADEIPLLDRR DPIIQQTVKK LRSQLQHALP
710 720 730 740 750
RYMVPTIWAF VGRMPMSASG KIDRVQLRNW VQEMSQETFD AITGRSFEAE
760 770 780 790 800
DHVLGLSRLE QEIQLAWAEA LGLSAAEVGL QQPFVALGGD SIKALDAVAR
810 820 830 840 850
CRTRQIKISM VHILSCEGVR EAASLAEVQE TPAQQVAEMA VDYSDLWTRL
860 870 880 890 900
STEYDLGKLG VTQVEDVEDV FPCTTMQEGM FLGQIRRPGA YHMRFFHRVQ
910 920 930 940 950
LKGGCLPTVD RIQQAWASLI ERHPSLRTIF VDDLSPDAIY HSVVLRSVPL
960 970 980 990 1000
ELTMREVPRD LSPEDALAMF TDELVPFRPN APLHRMLLLT CRGRVPYFML
1010 1020 1030 1040 1050
EISHVIMDGY ALSVFRREFI QACSSTGPLP RGPDYRMFAN YHRTRQTDDS
1060 1070 1080 1090 1100
AKYWTNYLSD CVPCHIPTHA VIAPTDAPPE WPRNLQRRDF SFNNSAAFLQ
1110 1120 1130 1140 1150
RCKERQVTLA CAIRAAWALV LRAYTQSQDV CFGYVSSGRN VPVPEVETIF
1160 1170 1180 1190 1200
GLCLSMQVCR ARLSESSTIA SLARKIQEDY VASLPFQHYP LAEAQRGLKQ
1210 1220 1230 1240 1250
THGQGLFNTA ISMEWVPPTA EDGDALLDLE EIREQDDPTE YDVAISVDIH
1260 1270 1280 1290 1300
EGHIKLGFLY WPNLTEFEIA HLAEALQGAM NCFAYQPDDA LDSLTLLQAS
1310 1320 1330 1340 1350
DVCSTLADGP TLLPLEAVRV NMLSMIDRRV TRQPDTPAIE GWDGSLSYKQ
1360 1370 1380 1390 1400
LHEQSCWVAR NLLHQGLQLG DRVLVCADRS SRTVATILGL VRAGCVLVLS
1410 1420 1430 1440 1450
NPTDPDKRLH WLAEKCNAAL IIADPAYEKR FATAGSRVLL TTAVCSPAAW
1460 1470 1480 1490 1500
DYEFPALDEH DLISILFTSG STGTPKGILM DHGALATSVL LGHGRTLRFS
1510 1520 1530 1540 1550
RQTRMLHFAS LTFDAALAEI FTTLAHGGCI CVPTEEDRLS DVPGCISRFA
1560 1570 1580 1590 1600
VNTAMLTPSV GRLLDPTALP MLKSLIMVGE PMSRLDVERF APVLDLYNGA
1610 1620 1630 1640 1650
GPTETSIMVT IAGPMTPTDE PTNLGHSVAG VRLWVTEAED PNRLAPLGAV
1660 1670 1680 1690 1700
GELIVEGRLV TRGYLDDGER TQQAFLPSLP WLPSQHALYR TGDLVRYADD
1710 1720 1730 1740 1750
GSLRYMGRKD TQVKLRGQRI ELQEVEYHLR KSLQQAQVVV EMVIPEGKTR
1760 1770 1780 1790 1800
AQASLVAFVS GLTAADVESS SACNSEESMT ISQVVLPKST IQTLEEALPR
1810 1820 1830 1840 1850
HMIPSVYYAL ETIPLSVNGK ADRRRLREMG ASLLASSAAN KSTADGKKEP
1860 1870 1880 1890 1900
AKWTAASELE RTLLELWATT LGLEVEAIHG DDSFFELGGD SVSAMKLVAT
1910 1920 1930 1940 1950
ARDKFKLSLS VPQMFRYPTI RQLAAELGES PRSSTSSASS STEDEFTIST
1960 1970 1980 1990 2000
PDDSSTNDGV DDDFLQLATA QLAQLAQEKG KKVDIAALLK QLQGGSSSSK
2010 2020 2030 2040 2050
TPSVSSSSSS SSSRKKKSSK AAFPVEAPGP VPEPFSLLNG DADVVEQVRA
2060 2070 2080 2090 2100
HAAEQCKIPH EDIEDIYPAT ALQEGMMALM ARTPGVYTTA LTCELSSQID
2110 2120 2130 2140 2150
LARLHSAWDK AAEAHPILRT RIIMTDDNTA VQVVQRAKGL PWDRYTLQDG
2160 2170 2180 2190 2200
ESIPNLTSDM TLGSPLLRLA EIHRHSKPPM LLVAIHHALY DGWSMPLLKQ
2210 2220 2230 2240 2250
AVEDAYHGQT LQPQPFTPFI NYLKEGKRAA QDFWTAHLDG FAGGVFPNLP
2260 2270 2280 2290 2300
SIDHHIQPSE RRSRSLTIPT AVSRNQYTMA TKIQAAWAVT VSRYAEDEDI
2310 2320 2330 2340 2350
VFGTVSTGRS APVPAIDRMV GPTITTVPVR ISLGDQAQRV SPLLQRVQED
2360 2370 2380 2390 2400
GWNRMDHEHL GLQYIGRLSE SAAAACRLQT LLVIQPREES HANSGATLLS
2410 2420 2430 2440 2450
GLQDSAELEG VDTYPLMLVC EPDGASLHLT AVFDPLVLDR TILERMLAHW
2460 2470 2480 2490 2500
ELVLTQLWTE PDMAVVDLDA VSYSDKQTLV QWNVGEKIAD GCAHDAVHEW
2510 2520 2530 2540 2550
SIRTPHAPAV CAWDGEWTYE ELDKCSSLLA SQILEHGVTS GDFVALYHEK
2560 2570 2580 2590 2600
SRWVAAGILA VFKAGGILVT LDPAHPKDRI RDILDQTQPR LILTSQSLLG
2610 2620 2630 2640 2650
EARELDTPVL CLQFAASQPV PERCSSPPTV SPTQAAYAPF TSGSTGRPKG
2660 2670 2680 2690 2700
VPLEHRGLAA STASVSRACL LRPASRVLHF ASFAFDASIM EPLVAWHAGG
2710 2720 2730 2740 2750
CLCIPDETAR QTDLARCIRD FDVTWAFLTP SCLRLITPDD VQCLEALALG
2760 2770 2780 2790 2800
GESMTPEDIS IWCPRLNQMV QLYGPAECCF VAALTEVTKP SENRLIGRPN
2810 2820 2830 2840 2850
ACRCWVVNPK SPERLAPLGA IGELMVEGIT VGQGYINNPE RTTQSFIQPP
2860 2870 2880 2890 2900
TWLQALYPDE EQPRHLYRTG DLVRYAGEDG KLTFIGRRDG QVKLHGQRIE
2910 2920 2930 2940 2950
LADVEAHLRP LIPAKHNIVV EMISSVDNQH PLLAAFVEEP SPSQGPQEQH
2960 2970 2980 2990 3000
IGLIHPSEAQ YALNVKTIDG ALSRTVPQHM IPSMYLHISR LPLSSSGKLN
3010 3020 3030 3040 3050
RRQLREMVAQ LPRQKLNEYA AGSCEMASQR PTTAKECEMQ AIWARVLAAD
3060 3070 3080 3090 3100
PDTIGLNDDF FRIGGDSISG MQIATKCNAA GMHITSADLF RHRTIAQLLF
3110 3120 3130 3140 3150
HLRNAKKRGD AISLPAEPVE EWVDLAPIQQ LFFEIAPEGS SHFNQSLLLR
3160 3170 3180 3190 3200
TSRHISVEEL TAGLDILVKR HSMLRASFRR SESGHWSQQV RSLDSPAGTF
3210 3220 3230 3240 3250
YRLATHNGIT RESLPSVFTT SQTSLSIQEG PLLAIDLVEL TDGSQLLYLV
3260 3270 3280 3290 3300
AHHLVIDLVS WRILHGELEQ YLQTGSLEPV TESVPFLTWS RAQAEYSAKH
3310 3320 3330 3340 3350
LTPVSALPRF QEAHDEFDGA RYWGIPPESN TFGQTSTFRF TLDQTATDTL
3360 3370 3380 3390 3400
FGTGNNVLGT RPVEILQAAL WYSFTQSLTD RPYPSIYVEG HGREPWADSI
3410 3420 3430 3440 3450
DISGTVGWFT TMSPLVFAPW DSLSRTSMED FLDALSYIKD QRRRVPANGW
3460 3470 3480 3490 3500
AYFTSRYLND EGKVAYGRMK PVVEILFNYM GQYQEMTRED AILQLAGDDI
3510 3520 3530 3540 3550
QSGTGAADIA DDVPRFSLID VGAFTANGCL SFEFIFPECI QRDARLKLWV
3560 3570 3580 3590 3600
ENCERMLLSA AKLLSNEGPR KTLSDFPLMP ELTYEQLSQC FEHTLPSMGL
3610 3620 3630 3640 3650
SASDVVNIYP CSSVQQGMLL AQLRDPQAYQ QRFKFHVKSD ERRLTLEQVK
3660 3670 3680 3690 3700
DAWREVINRH DILRTLLLPV SDHGHLDQVV MAPGSLQHLV RIDATDVNLT
3710 3720 3730 3740 3750
QGIPHSINIT RDSSGTVVCE WNVSHVLVDA MSVAVIQLEV SQSLDGLLGQ
3760 3770 3780 3790 3800
HEKPGQYADY IQWVSRRDKT ETQAYWQRYL EGVEPCLFPK LTSTSDNVKP
3810 3820 3830 3840 3850
EGTISAVRAT WDRDARMDEL CQKHGITLTN LFHIVWALVL GAYVGTDDVC
3860 3870 3880 3890 3900
FGYTTLGRDV PVDGVEMMVG PLVNVLATTV QLRDEDSILD ALRTHQAHLT
3910 3920 3930 3940 3950
NSLQHQHHAL ADVYASIGLV GSQLFNTIVS LQDVSHFDAP DEQSTRLEVQ
3960 3970 3980 3990 4000
PANDASEVCH YLLVYKCFIF FDVNFRKYDV ALNIGVGSSS IQLVCSYRTL
4010 4020 4030 4040 4050
SLSAEHADTL LRTASHVLSE ILRDPTQRIQ EIEIISPECK EQLVKWNPTV
4060 4070 4080 4090 4100
PAPSDEYIHE KIQGQCRLHS SRQAVCAWDG IFTYAELDDL SSRLAVRLTR
4110 4120 4130 4140 4150
MGATSEHIIP IYSPRSRWTV IAILGVLKTG AAFTLLEVSH PMNRLQEVCK
4160 4170 4180 4190 4200
QIDASVIIAP ASHATSAASL APILVVLDNI TSMTPGQSES SPAVRMPPAS
4210 4220 4230 4240 4250
EALAYLIFTS GSTGNPKGVM VTHQNLCSNA SIMTTSVNMT ADSRVLQFAS
4260 4270 4280 4290 4300
YAFDASLWEM LGALFAGACL VIPSESESKE DLAGCIDRMA VTWAFLTPSV
4310 4320 4330 4340 4350
ARILKPERVP QLRVLALGGE PIAVSDLDTW RTHAQVVCAY GPSETAILAS
4360 4370 4380 4390 4400
TTSPSTIPTV GKDIGMPTTC SLWIVDKRDY QKLAPLGATG ELLIEGPNVS
4410 4420 4430 4440 4450
KGYLGDPEKT NEAFPVAPRW LSQLRQSPTR VYRTGDLVRF DQSTGTLRFV
4460 4470 4480 4490 4500
GRKDNQIKFH GQRIELGDIE NHAQQALPNA STVIVDLISP GESQQSYLVA
4510 4520 4530 4540 4550
FVYQPDTSTQ TADAIDPILL PPSESFRTDA LAAQKHMHDR LPHYMVPTAF
4560 4570 4580 4590 4600
LPLNCLPLSN TGKADRKRLR HCALALSGSE LNAYRATATA KRMPSTEAEC
4610 4620 4630 4640 4650
IMQQLIATVL GRDASEIGMD DSFFHLGGDS VQAMRLVSEG RQQGLTLSLR
4660 4670 4680 4690 4700
TIFDSPRLDD LARHNSLVQD DQPAAASPAT MHDTFSLIDK LVSTYPIDKA
4710 4720 4730 4740 4750
AVVDILPTTS FQRHWLDAQL KSYIVVDIPG RISRDRLFTA MQRVVDAHPI
4760 4770 4780 4790 4800
LRTSFVPHDN TAVQVILRTA FAITDADLST TTVEDLCRQD ANAAIAPGAP
4810 4820 4830 4840 4850
YLRVILATGE FGYKLIMRLS HAQYDAVSLS LLMNDLGHAY ENDTHELPSS
4860 4870 4880 4890 4900
YSPSFTDYIT YQQRQKVDST ATTFWRHLLQ DVPLTSLDLQ PSKPSTSNGT
4910 4920 4930 4940 4950
PITRTRDINI ATFPQLPNGI TLATAVKAAW SIVLAQKTNS PAVIFGQVVH
4960 4970 4980 4990 5000
GRGIPLPGVE GIVGPCANIT PVVARLSPQT TGLELLQALQ DQHRSGLSYE
5010 5020 5030 5040 5050
AVDLDDALAY TKGWQAGSPR VQTIVQHQNN VMTDGMGLSL GEVKCGVDVR
5060 5070 5080 5090 5100
AVDHVPREVW VYSSVDENKP GMLEVKIMSS TLVLSEEVAE ELMDLVVEKV
5110
VALLRDPRGV CV
Length:5,112
Mass (Da):563,090
Last modified:March 15, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i60BC6ED30CA7BC27
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
KV878693 Genomic DNA Translation: OJJ67652.1

Genome annotation databases

Ensembl fungal genome annotation project

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EnsemblFungii
OJJ67652; OJJ67652; ASPBRDRAFT_34020

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KV878693 Genomic DNA Translation: OJJ67652.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblFungiiOJJ67652; OJJ67652; ASPBRDRAFT_34020

Phylogenomic databases

OrthoDBi4243at2759

Family and domain databases

Gene3Di1.10.1200.10, 4 hits
3.30.559.10, 5 hits
3.40.50.12780, 4 hits
InterProiView protein in InterPro
IPR010071 AA_adenyl_domain
IPR036736 ACP-like_sf
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501 AMP-binding, 4 hits
PF00668 Condensation, 5 hits
PF00550 PP-binding, 4 hits
SMARTiView protein in SMART
SM00823 PKS_PP, 3 hits
SUPFAMiSSF47336 SSF47336, 4 hits
TIGRFAMsiTIGR01733 AA-adenyl-dom, 4 hits
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 3 hits
PS50075 CARRIER, 4 hits
PS00012 PHOSPHOPANTETHEINE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMLFA_ASPBC
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1L9U7P9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 10, 2019
Last sequence update: March 15, 2017
Last modified: July 3, 2019
This is version 17 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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