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Entry version 12 (31 Jul 2019)
Sequence version 1 (15 Mar 2017)
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Protein

CBM21 domain-containing protein

Gene

ppp1r3a

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CBM21 domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ppp1r3aImported
ORF Names:XELAEV_18017628mgImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000186698 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3l

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-17332406 ppp1r3a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1029 – 1059HelicalSequence analysisAdd BLAST31

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini138 – 248CBM21InterPro annotationAdd BLAST111

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni15 – 51DisorderedSequence analysisAdd BLAST37
Regioni267 – 295DisorderedSequence analysisAdd BLAST29
Regioni307 – 326DisorderedSequence analysisAdd BLAST20
Regioni459 – 482DisorderedSequence analysisAdd BLAST24
Regioni571 – 599DisorderedSequence analysisAdd BLAST29
Regioni809 – 828DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi15 – 34PolarSequence analysisAdd BLAST20
Compositional biasi312 – 326AcidicSequence analysisAdd BLAST15
Compositional biasi459 – 476PolyampholyteSequence analysisAdd BLAST18
Compositional biasi574 – 599PolyampholyteSequence analysisAdd BLAST26
Compositional biasi812 – 828PolarSequence analysisAdd BLAST17

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K07189

Database of Orthologous Groups

More...
OrthoDBi
1232750at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.2440, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005036 CBM21_dom
IPR038175 CBM21_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03370 CBM_21, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51159 CBM21, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1L8GYV2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAASSCLAL SLCRSKSPME NTEENNQSKD SLLEPPPLGN SYIEDEDEKS
60 70 80 90 100
SIKLRFSPLP RRRSSVSSDE GDLEPPTTVA RKVSFADAFG FDLVSVKEFD
110 120 130 140 150
TWEVPIVSQI LSYEMETHYI EEFYLTASFT LPSSDDIMGK LHAKKVLLES
160 170 180 190 200
IELTPGTSSM KGIIRVLNVS YEKQIYVRMS MDDWQSYYDL TAEYIPYSFN
210 220 230 240 250
ADTDQFAFAI SLVAPYQKEG ASVQFCISYE TPIGTFWDNN DGQNYTLICH
260 270 280 290 300
KKECAIEKDH PSEDLAEKSK KSCLKSAPSK EEDDLDESEE KYSRSTDKYI
310 320 330 340 350
PRIICSHDEN TEDNNNEEDD SQENNKEADD DLELFLNQNL MKARIISTED
360 370 380 390 400
NKSNKTQIFE EPSLTNTIQT CESLECLKDS SIDILKKIND NISAKESKEF
410 420 430 440 450
NGNEVCLTLS DSHKTLIAED IKSTSRTEQH LKEAGISLQE YLPQNGGDLN
460 470 480 490 500
QKKWLTDSKD DTSVLQGKEE EKWSLTTNRN QEPYNEIEST LSPKTESVQL
510 520 530 540 550
TENLDDNANP NTSNKIVDAS YFSIYNEERM KDENNQFPEN KKINRCFFNK
560 570 580 590 600
AESSQLEQDY STISLNQKYT APVVSEDPDK KDEQSFLRSP EAERKQPSLD
610 620 630 640 650
AAHDCKIFKN TVSDQVAFSC NACLDNQGQI KDINDEKTSK AKRVTTTFSF
660 670 680 690 700
PCDTTDDTSN QGSLEVLFEN KITKKEIYAH TNDSQTVHLQ KSKQCYISTF
710 720 730 740 750
NVSEESQIFE SPLITSNTPL TSQDQDDKDK ARVVDTPDLK IRSKLDCPVH
760 770 780 790 800
TTDRAESTEN QLTMGEKVII ALVTEETSER EICIPVPYID VCTDVSKNTV
810 820 830 840 850
DQEDTKIGVE SESQKVSDNL NKGQGGRNIE SEEITNTPLD DMKVLASIKR
860 870 880 890 900
DGDNGQMQRT TTAKMPGADA IYMGAYNVFK DQFKSNLDDF SNNITTVEES
910 920 930 940 950
DSQMTDNSHT ESSNSLCAEL SGNFSKLVKE QGDTIDNSII SGSTTDMSGM
960 970 980 990 1000
LHAQENTEQN YLRPSILISE PDDELERWCN QDEEKSEPED MNQCYYYSET
1010 1020 1030 1040 1050
NQQTQTGDHE MEDDPLNFSK TSSKVICSVM FVVFSGLMYH YDFLVCFALY
1060 1070
LFSLYWLYWD GDGNKKSVKK E
Length:1,071
Mass (Da):121,326
Last modified:March 15, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4F81B39671B141DC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CM004470 Genomic DNA Translation: OCT88999.1

NCBI Reference Sequences

More...
RefSeqi
XP_018108040.1, XM_018252551.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
108711133

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:108711133

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM004470 Genomic DNA Translation: OCT88999.1
RefSeqiXP_018108040.1, XM_018252551.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi108711133
KEGGixla:108711133

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
108711133
XenbaseiXB-GENE-17332406 ppp1r3a

Phylogenomic databases

KOiK07189
OrthoDBi1232750at2759

Family and domain databases

Gene3Di2.60.40.2440, 1 hit
InterProiView protein in InterPro
IPR005036 CBM21_dom
IPR038175 CBM21_dom_sf
PfamiView protein in Pfam
PF03370 CBM_21, 1 hit
PROSITEiView protein in PROSITE
PS51159 CBM21, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1L8GYV2_XENLA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1L8GYV2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 15, 2017
Last sequence update: March 15, 2017
Last modified: July 31, 2019
This is version 12 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health

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