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Entry version 21 (29 Sep 2021)
Sequence version 1 (15 Mar 2017)
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Protein

Methylcytosine dioxygenase tet3-A

Gene

tet3-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development. Conversion of 5mC into 5hmC probably constitutes the first step in cytosine demethylation. Selectively binds to the promoter region of target genes and contributes to regulate the expression of numerous developmental genes, including pax6, rax, sox9 and six3. May also contribute to the regulation of target genes in ways that do not require its enzyme activity.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi69Zinc 1PROSITE-ProRule annotation1
Metal bindingi72Zinc 1PROSITE-ProRule annotation1
Metal bindingi75Zinc 1PROSITE-ProRule annotation1
Metal bindingi81Zinc 2PROSITE-ProRule annotation1
Metal bindingi84Zinc 2PROSITE-ProRule annotation1
Metal bindingi87Zinc 2PROSITE-ProRule annotation1
Metal bindingi97Zinc 2PROSITE-ProRule annotation1
Metal bindingi102Zinc 1PROSITE-ProRule annotation1
Metal bindingi982Zinc 3By similarity1
Metal bindingi984Zinc 3By similarity1
Metal bindingi1042Zinc 4By similarity1
Metal bindingi1068Zinc 1; via pros nitrogenBy similarity1
Metal bindingi1070Zinc 3By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei11102-oxoglutarateBy similarity1
Metal bindingi1120Zinc 4By similarity1
Metal bindingi1122Zinc 4By similarity1
Metal bindingi1138Zinc 3By similarity1
Metal bindingi1147Zinc 3By similarity1
Metal bindingi1207Zinc 3By similarity1
Binding sitei12232-oxoglutarateBy similarity1
Metal bindingi1229Zinc 2; via tele nitrogenBy similarity1
Metal bindingi1231Iron; catalyticBy similarity1
Metal bindingi1233Iron; catalyticBy similarity1
Binding sitei12652-oxoglutarateBy similarity1
Metal bindingi1804Iron; catalyticBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri62 – 103CXXC-typePROSITE-ProRule annotationAdd BLAST42

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Developmental protein, Dioxygenase, DNA-binding, Oxidoreductase
LigandIron, Metal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Methylcytosine dioxygenase tet3-A (EC:1.14.11.n21 Publication)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tet3-aImported
ORF Names:XELAEV_18020377mgImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000186698 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 3s, Unassembled WGS sequence

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-17338508, tet3.S

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Morpholino knockdown of both tet3-a and tet3-b causes defects in embryonic development, including malformations of the eye (eyeless), small head, and missing pigmentation along the lateral body, leading to embryonic death between stages 35 and 40.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004423151 – 1925Methylcytosine dioxygenase tet3-AAdd BLAST1925

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in embryo (at protein level). Detected in embryonic head, in developing brain, neural tube and eye.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression in oocytes is very low. Barely detectable from stage 2 (2-cell stage) to stage 9. Increases strongly from stage 9 to 17, and decreases again at stage 25.1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A1L8GSA2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni457 – 476DisorderedSequence analysisAdd BLAST20
Regioni630 – 685DisorderedSequence analysisAdd BLAST56
Regioni774 – 812DisorderedSequence analysisAdd BLAST39
Regioni833 – 892DisorderedSequence analysisAdd BLAST60
Regioni1307 – 1364DisorderedSequence analysisAdd BLAST58
Regioni1474 – 1513DisorderedSequence analysisAdd BLAST40
Regioni1556 – 1600DisorderedSequence analysisAdd BLAST45
Regioni1722 – 1769DisorderedSequence analysisAdd BLAST48
Regioni1819 – 18212-oxoglutarate bindingBy similarity3

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1837 – 1870Sequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi655 – 676Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi774 – 808Polar residuesSequence analysisAdd BLAST35
Compositional biasi838 – 852Polar residuesSequence analysisAdd BLAST15
Compositional biasi866 – 892Polar residuesSequence analysisAdd BLAST27
Compositional biasi1307 – 1346Basic and acidic residuesSequence analysisAdd BLAST40
Compositional biasi1347 – 1364Polar residuesSequence analysisAdd BLAST18
Compositional biasi1556 – 1595Polar residuesSequence analysisAdd BLAST40
Compositional biasi1725 – 1746Polar residuesSequence analysisAdd BLAST22
Compositional biasi1747 – 1764Basic and acidic residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Binds target DNA that contains at least one unmethylated cytosine via the CXXC-type zinc-finger domain.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TET family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri62 – 103CXXC-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
VMVGGFQ

Database of Orthologous Groups

More...
OrthoDBi
29059at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024779, 2OGFeDO_noxygenase_dom
IPR040175, TET1/2/3
IPR002857, Znf_CXXC

The PANTHER Classification System

More...
PANTHERi
PTHR23358, PTHR23358, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12851, Tet_JBP, 1 hit
PF02008, zf-CXXC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01333, Tet_JBP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51058, ZF_CXXC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1L8GSA2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMETQPTSLP HVLPQDVYEF CDDRKSLGRL RVSEMPAESN GDGGGSKGDG
60 70 80 90 100
AAVVAKEVPE QSNKKRKRCG VCVPCLRKEP CGACYNCVNR STSHQICKMR
110 120 130 140 150
KCEQLKKKRV VPLKGVEAVN KDDSKNQAKE QVPNVKNCSE SILVDGPKTD
160 170 180 190 200
QMEAGPVNHV QEGRLKKECD STLPSKACED LANQLLMEAN SWLSNTAAPQ
210 220 230 240 250
DPCNKLNWDK PTIPNHTAAT NNSNLEDAKN LVAFSAVAEA MSNYGMPASG
260 270 280 290 300
TPSSVSMQLY EKFNYETNRD SSGHPEGNAP SCPEDLNTLK TALALAKHGV
310 320 330 340 350
KPPNCNCDGP ECPDYLEWLE NKIKSSQKDS QESSFPGLGQ VSKELVQKSY
360 370 380 390 400
PKEEVLNLEN KNLCPSGNLP FSQNALSLAK EKNISLQTAI AIEALTQLSS
410 420 430 440 450
ALPQTNNECP NSSSQPLINT CDQLTHFPTA KGNQLPIFPM ACNELFQNQQ
460 470 480 490 500
SQLYTGKNAL PVPQSPRQTS WEQNKKPSYQ EGQYIPENLS QSSSVLPSDA
510 520 530 540 550
STPQKTEFLQ QWIQNADLLK SPSDPMTGLK QLLGNTDEYI KSVFKGPEAL
560 570 580 590 600
PNKIKHVKTK RTIKSIKKKS SDFLKMSPDQ QLSQLLQEND FHHNAQAALQ
610 620 630 640 650
QHLHHKRNLF VDPNTMEACA QEQQNWWVPK SQKLPVSKTT ENPVKERKKR
660 670 680 690 700
RQRSPSQKQV EPKPKPPRKQ VQIKKPRMKE GNAVFMPVSQ ISLDAFRGAE
710 720 730 740 750
KEENQLKEMN LEKSLSNNIQ PDLLESQSIL VTGSQANIEN RKTVNTQETC
760 770 780 790 800
NENQASNGKA SNFALCVNQA NSLGAKDSCP TPSTDDASSS SGQGDSANQH
810 820 830 840 850
TNVGDVPGQN DLSCLDDKFE DLLRQFEAEF GEDFSLPGSE APSQNGVGPP
860 870 880 890 900
KQQISGDPQF KMPFPSQLLP SENSTRPDAH SNPALSNNPI SHNVSHNLDS
910 920 930 940 950
LFSSKSPKKI KIESSGAITV VSTTCFYSEE NQHLDGTPTK SDLPFNPTLS
960 970 980 990 1000
GFLESPLKYL TSPTKSLIDT PAKMAQAEFP TCDCVEQINE KDEGPYYTHL
1010 1020 1030 1040 1050
GSGPTVASIR ELMEDRFGEK GEAIRIEKVI YTGKEGKSSR GCPIAKWVIR
1060 1070 1080 1090 1100
RQSEDEKLMC LVRQRAGHHC ENAVIIILIM AWEGIPRALG DSLYSDITET
1110 1120 1130 1140 1150
ITKYGNPTSR RCGLNDDRTC ACQGKDPNTC GASFSFGCSW SMYFNGCKYA
1160 1170 1180 1190 1200
RSKTPRKFRL IGDNPKEEEF LNDNFQDLAT KVAPVYQMLA PQSYENQVNN
1210 1220 1230 1240 1250
EEVAIDCRLG LKEGRPFSGV TACMDFCAHA HKDQHNLYNG CTVVCTLTKE
1260 1270 1280 1290 1300
DNRTIGRIPE DEQLHVLPLY KVSSTDEFGS EDGQAEKIRK GGIQVLASFP
1310 1320 1330 1340 1350
REVRKLSEPA KSCRQRQLDA KKAAAEKKKL QKEKLVSPDK TKQEPADTKM
1360 1370 1380 1390 1400
CQQNPGVPQQ QTKPCVKVEP SNHYNTYKYN GNGVVESYSV LGSCRPSDPY
1410 1420 1430 1440 1450
SMNSVYSYHS FYAQPNLPSV NGFHSKFALP PFGFYGFPNN PVVPNQFMNY
1460 1470 1480 1490 1500
GTSDARNSGW MNNSFEKKPD VQSLADGMNQ SYGSELPEQS YRRSSEVPHH
1510 1520 1530 1540 1550
YSLQNPNSQK SFNISHRTTP SPMETTPYSN LPCYNKVIKK EPVCDPLVDP
1560 1570 1580 1590 1600
FQRANSVHSQ SPGVNHSLQT SDLPFKANGA LPSSGRSNAE GPCSMSLPND
1610 1620 1630 1640 1650
KSGLEKRDYF GVHSNVPALK DKQWTPYGTD VPVGQRDSLD AQSPGKVWSS
1660 1670 1680 1690 1700
CKLSDSPAVL PSFASTQTKN WNGRQASLNQ GLKEPMPFQE KLWNSVAASD
1710 1720 1730 1740 1750
RCSVTPSDRS SVTPCAELQD KNWASFPNPV GNSLKTESSQ NHWDPYSLDD
1760 1770 1780 1790 1800
NMDDGQSKSV KEEEDEEEIW SDSEHNFLDK NIGGVAVAPG HGSILIECAR
1810 1820 1830 1840 1850
RELHATTPLK KPNRCHPARI SLVFYQHKNL NQPNHGLALW EAKMKLLAER
1860 1870 1880 1890 1900
ARVKEEEAAR LGIKQEVKSL GKKRKWGGAA TTETPPVEKK DFIPTRQATT
1910 1920
ILTDSATTAF SYAYTKVTGP YSRFI
Length:1,925
Mass (Da):213,144
Last modified:March 15, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5A1C1757BF9BAEAC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1Missing in ADU77105 (PubMed:23217707).Curated1
Sequence conflicti598A → V in ADU77105 (PubMed:23217707).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CM004471 Genomic DNA Translation: OCT86689.1
HQ220207 mRNA Translation: ADU77105.1

NCBI Reference Sequences

More...
RefSeqi
XP_018110686.1, XM_018255197.1
XP_018110687.1, XM_018255198.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
108712780

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:108712780

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM004471 Genomic DNA Translation: OCT86689.1
HQ220207 mRNA Translation: ADU77105.1
RefSeqiXP_018110686.1, XM_018255197.1
XP_018110687.1, XM_018255198.1

3D structure databases

SMRiA0A1L8GSA2
ModBaseiSearch...

Genome annotation databases

GeneIDi108712780
KEGGixla:108712780

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
108712780
XenbaseiXB-GENE-17338508, tet3.S

Phylogenomic databases

OMAiVMVGGFQ
OrthoDBi29059at2759

Family and domain databases

InterProiView protein in InterPro
IPR024779, 2OGFeDO_noxygenase_dom
IPR040175, TET1/2/3
IPR002857, Znf_CXXC
PANTHERiPTHR23358, PTHR23358, 1 hit
PfamiView protein in Pfam
PF12851, Tet_JBP, 1 hit
PF02008, zf-CXXC, 1 hit
SMARTiView protein in SMART
SM01333, Tet_JBP, 1 hit
PROSITEiView protein in PROSITE
PS51058, ZF_CXXC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTET3A_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1L8GSA2
Secondary accession number(s): K9JHZ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2017
Last sequence update: March 15, 2017
Last modified: September 29, 2021
This is version 21 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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