Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 19 (07 Apr 2021)
Sequence version 1 (15 Mar 2017)
Previous versions | rss
Add a publicationFeedback
Protein

DNA polymerase

Gene

polb.S

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.

UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+ARBA annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei72Schiff-base intermediate with DNAUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-directed DNA polymeraseUniRule annotationARBA annotation, LyaseARBA annotation, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA repairUniRule annotationARBA annotation, DNA replicationARBA annotation, DNA synthesisARBA annotation
LigandSodiumARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymeraseUniRule annotation (EC:2.7.7.7UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:polb.SImported
Synonyms:polbImported
ORF Names:XELAEV_18020165mgImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000186698 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3s

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-999702, polb.S

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusUniRule annotationARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

MethylationARBA annotation, Ubl conjugationARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A1L8GRP9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 333POLXcInterPro annotationAdd BLAST324
Domaini57 – 76HhH1InterPro annotationAdd BLAST20
Domaini98 – 117HhH1InterPro annotationAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili22 – 42Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-X family.UniRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
ITDMLME

Database of Orthologous Groups

More...
OrthoDBi
1328151at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00141, NT_POLXc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.110, 1 hit
3.30.210.10, 1 hit
3.30.460.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002054, DNA-dir_DNA_pol_X
IPR019843, DNA_pol-X_BS
IPR010996, DNA_pol_b-like_N
IPR028207, DNA_pol_B_palm_palm
IPR018944, DNA_pol_lambd_fingers_domain
IPR027421, DNA_pol_lamdba_lyase_dom_sf
IPR037160, DNA_Pol_thumb_sf
IPR022312, DNA_pol_X
IPR002008, DNA_pol_X_beta-like
IPR003583, Hlx-hairpin-Hlx_DNA-bd_motif
IPR043519, NT_sf
IPR029398, PolB_thumb

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14792, DNA_pol_B_palm, 1 hit
PF14791, DNA_pol_B_thumb, 1 hit
PF10391, DNA_pol_lambd_f, 1 hit
PF14716, HHH_8, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00869, DNAPOLX
PR00870, DNAPOLXBETA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00278, HhH1, 2 hits
SM00483, POLXc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47802, SSF47802, 1 hit
SSF81301, SSF81301, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00522, DNA_POLYMERASE_X, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1L8GRP9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKRKAPQES PNEGITDFLV ELANYERNVN RAIHKYNAYR KAASVIAKYP
60 70 80 90 100
TKIKSGTEAK KLDGVGAKIA EKIDEFLATG KLRKLEKIRQ DDTSSSINFL
110 120 130 140 150
TRVTGIGPAA ARKFFDEGIK TLDDLRNNEH KLNHHQKIGL KHFDDFEKRI
160 170 180 190 200
PRKEMLQMQE IILDKVNNLD PEYIATVCGS FRRGAESSGD MDILLTHPDF
210 220 230 240 250
TSESAKQPRL LHQVVQCLED CNFITDTLVK GDTKFMGVCQ LPCESDQDYP
260 270 280 290 300
YRRIDIRLIP KDQYYCGVLY FTGSDIFNKN MRTHALEKGF TLNEYTLRPL
310 320 330
GVTGIAGEPL PIDSEKDIFD YIQWKYREPK DRSE
Length:334
Mass (Da):38,294
Last modified:March 15, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i33073FF0D0554458
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CM004471 Genomic DNA Translation: OCT86481.1

NCBI Reference Sequences

More...
RefSeqi
NP_001081643.1, NM_001088174.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
397973

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:397973

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM004471 Genomic DNA Translation: OCT86481.1
RefSeqiNP_001081643.1, NM_001088174.1

3D structure databases

SMRiA0A1L8GRP9
ModBaseiSearch...

Genome annotation databases

GeneIDi397973
KEGGixla:397973

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
397973
XenbaseiXB-GENE-999702, polb.S

Phylogenomic databases

OMAiITDMLME
OrthoDBi1328151at2759

Family and domain databases

CDDicd00141, NT_POLXc, 1 hit
Gene3Di1.10.150.110, 1 hit
3.30.210.10, 1 hit
3.30.460.10, 1 hit
InterProiView protein in InterPro
IPR002054, DNA-dir_DNA_pol_X
IPR019843, DNA_pol-X_BS
IPR010996, DNA_pol_b-like_N
IPR028207, DNA_pol_B_palm_palm
IPR018944, DNA_pol_lambd_fingers_domain
IPR027421, DNA_pol_lamdba_lyase_dom_sf
IPR037160, DNA_Pol_thumb_sf
IPR022312, DNA_pol_X
IPR002008, DNA_pol_X_beta-like
IPR003583, Hlx-hairpin-Hlx_DNA-bd_motif
IPR043519, NT_sf
IPR029398, PolB_thumb
PfamiView protein in Pfam
PF14792, DNA_pol_B_palm, 1 hit
PF14791, DNA_pol_B_thumb, 1 hit
PF10391, DNA_pol_lambd_f, 1 hit
PF14716, HHH_8, 1 hit
PRINTSiPR00869, DNAPOLX
PR00870, DNAPOLXBETA
SMARTiView protein in SMART
SM00278, HhH1, 2 hits
SM00483, POLXc, 1 hit
SUPFAMiSSF47802, SSF47802, 1 hit
SSF81301, SSF81301, 1 hit
PROSITEiView protein in PROSITE
PS00522, DNA_POLYMERASE_X, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1L8GRP9_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1L8GRP9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 15, 2017
Last sequence update: March 15, 2017
Last modified: April 7, 2021
This is version 19 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again