UniProtKB - A0A1L8F936 (A0A1L8F936_XENLA)
Protein
Transforming growth factor beta
Gene
tgfb1.L
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.ARBA annotation
GO - Molecular functioni
- growth factor activity Source: UniProtKB-UniRule
- transforming growth factor beta receptor binding Source: InterPro
GO - Biological processi
- positive regulation of cell division Source: UniProtKB-UniRule
Keywordsi
Molecular function | Growth factorUniRule annotationARBA annotation, MitogenUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Transforming growth factor betaUniRule annotation |
Gene namesi | ORF Names:XELAEV_18039344mgImported |
Organismi | Xenopus laevis (African clawed frog)Imported |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-865765, tgfb1.L |
Subcellular locationi
Extracellular region or secreted
- Secreted UniRule annotationARBA annotation
Extracellular region or secreted
- extracellular space Source: UniProtKB-UniRule
Keywords - Cellular componenti
Extracellular matrixARBA annotation, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | UniRule annotationAdd BLAST | 21 | |
ChainiPRO_5016196675 | 22 – 382 | Transforming growth factor betaUniRule annotationAdd BLAST | 361 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 277 ↔ 286 | UniRule annotation | ||
Disulfide bondi | 285 ↔ 348 | UniRule annotation | ||
Disulfide bondi | 314 ↔ 379 | UniRule annotation | ||
Disulfide bondi | 318 ↔ 381 | UniRule annotation | ||
Disulfide bondi | 347 | InterchainUniRule annotation |
Keywords - PTMi
Disulfide bondUniRule annotationInteractioni
Subunit structurei
Homodimer; disulfide-linked.
UniRule annotationGO - Molecular functioni
- growth factor activity Source: UniProtKB-UniRule
- transforming growth factor beta receptor binding Source: InterPro
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 267 – 382 | TGF_BETA_2InterPro annotationAdd BLAST | 116 |
Sequence similaritiesi
Keywords - Domaini
SignalUniRule annotationARBA annotationPhylogenomic databases
OMAi | MAKEPEP |
OrthoDBi | 643840at2759 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR016319, TGF-beta IPR015615, TGF-beta-rel IPR003939, TGFb1 IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF001787, TGF-beta, 1 hit |
PRINTSi | PR01423, TGFBETA PR01424, TGFBETA1 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A1L8F936-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEVLWMLLVL LVLHLSSLAM SLSTCKAVDM EEVRKRRIEA IRGQILSKLK
60 70 80 90 100
LDKTPDVDSE KMTVPSEAIF LYNSTLEVIR EKATREEEHV GHDQNIQDYY
110 120 130 140 150
AKQVYRFESI TELEDHEFKF KFNASHVREN VGMNSLLHHA ELRMYKKQTD
160 170 180 190 200
KNMDQRMELF WKYQENGTTH SRYLESKYIT PVTDDEWMSF DVTKTVNEWL
210 220 230 240 250
KRAEENEQFG LQPACKCPTP QAKDIDIEGF PALRGDLASL SSKENTKPYL
260 270 280 290 300
MITSMPAERI DTVTSSRKKR GVGQEYCFGN NGPNCCVKPL YINFRKDLGW
310 320 330 340 350
KWIHEPKGYE ANYCLGNCPY IWSMDTQYSK VLSLYNQNNP GASISPCCVP
360 370 380
DVLEPLPIIY YVGRTAKVEQ LSNMVVRSCN CS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CM004480 Genomic DNA Translation: OCT68048.1 |
RefSeqi | NP_001081330.1, NM_001087861.1 |
Genome annotation databases
GeneIDi | 397778 |
KEGGi | xla:397778 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CM004480 Genomic DNA Translation: OCT68048.1 |
RefSeqi | NP_001081330.1, NM_001087861.1 |
3D structure databases
SMRi | A0A1L8F936 |
ModBasei | Search... |
Protocols and materials databases
DNASUi | 397778 |
Genome annotation databases
GeneIDi | 397778 |
KEGGi | xla:397778 |
Organism-specific databases
CTDi | 397778 |
Xenbasei | XB-GENE-865765, tgfb1.L |
Phylogenomic databases
OMAi | MAKEPEP |
OrthoDBi | 643840at2759 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR016319, TGF-beta IPR015615, TGF-beta-rel IPR003939, TGFb1 IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF001787, TGF-beta, 1 hit |
PRINTSi | PR01423, TGFBETA PR01424, TGFBETA1 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A1L8F936_XENLA | |
Accessioni | A0A1L8F936Primary (citable) accession number: A0A1L8F936 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 15, 2017 |
Last sequence update: | March 15, 2017 | |
Last modified: | April 7, 2021 | |
This is version 21 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |