UniProtKB - A0A1L8F5J9 (NMDZ1_XENLA)
Glutamate receptor ionotropic, NMDA 1
grin1
Functioni
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 67 | Zinc; via tele nitrogen1 Publication | 1 | |
Metal bindingi | 94 | Zinc1 Publication | 1 | |
Metal bindingi | 100 | Zinc1 Publication | 1 | |
Binding sitei | 521 | GlycineBy similarity | 1 | |
Binding sitei | 686 | GlycineBy similarity | 1 | |
Binding sitei | 730 | GlycineBy similarity | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- NMDA glutamate receptor activity Source: UniProtKB
GO - Biological processi
- response to zinc ion Source: UniProtKB
Keywordsi
Molecular function | Ion channel, Ligand-gated ion channel, Receptor |
Biological process | Ion transport, Transport |
Ligand | Calcium, Magnesium, Metal-binding, Zinc |
Protein family/group databases
TCDBi | 1.A.10.1.12, the glutamate-gated ion channel (gic) family of neurotransmitter receptors |
Names & Taxonomyi
Protein namesi | Recommended name: Glutamate receptor ionotropic, NMDA 1Short name: GluN1 Alternative name(s): N-methyl-D-aspartate receptor subunit NR11 Publication Short name: NMD-R1 |
Gene namesi | Name:grin1Imported |
Organismi | Xenopus laevis (African clawed frog)Imported |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-866327, grin1.L |
Subcellular locationi
Plasma membrane
- Cell membrane 7 Publications; Multi-pass membrane protein 3 Publications
- postsynaptic cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Plasma membrane
- Cell membrane 2 Publications; Multi-pass membrane protein Curated
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Curated
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- NMDA selective glutamate receptor complex Source: UniProtKB
- postsynaptic membrane Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 557 | ExtracellularCuratedAdd BLAST | 537 | |
Transmembranei | 558 – 578 | Helical1 PublicationAdd BLAST | 21 | |
Topological domaini | 579 – 600 | CytoplasmicCuratedAdd BLAST | 22 | |
Intramembranei | 601 – 622 | Discontinuously helical1 PublicationAdd BLAST | 22 | |
Topological domaini | 623 – 628 | CytoplasmicCurated | 6 | |
Transmembranei | 629 – 645 | Helical1 PublicationAdd BLAST | 17 | |
Topological domaini | 646 – 810 | ExtracellularCuratedAdd BLAST | 165 | |
Transmembranei | 811 – 831 | Helical1 PublicationAdd BLAST | 21 | |
Topological domaini | 832 – 903 | CytoplasmicCuratedAdd BLAST | 72 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000442209 | 21 – 903 | Glutamate receptor ionotropic, NMDA 1Sequence analysisAdd BLAST | 883 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 61 | N-linked (GlcNAc...) asparagineCombined sources2 Publications | 1 | |
Disulfide bondi | 79 ↔ 308 | Combined sources1 Publication | ||
Glycosylationi | 203 | N-linked (GlcNAc...) asparagineCombined sources3 Publications | 1 | |
Glycosylationi | 276 | N-linked (GlcNAc...) asparagineCombined sources3 Publications | 1 | |
Glycosylationi | 300 | N-linked (GlcNAc...) asparagineCombined sources2 Publications | 1 | |
Glycosylationi | 350 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 368 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 | |
Disulfide bondi | 420 ↔ 452 | Combined sources1 Publication | ||
Disulfide bondi | 436 ↔ 453 | Combined sources1 Publication | ||
Glycosylationi | 440 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 469 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 489 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Disulfide bondi | 742 ↔ 796 | Combined sources1 Publication | ||
Glycosylationi | 769 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinPTM databases
iPTMneti | A0A1L8F5J9 |
Interactioni
Subunit structurei
Heterotetramer (PubMed:27062927). Forms heterotetrameric channels composed of two zeta subunits (grin1), and two epsilon subunits (grin2a, grin2b, grin2c or grin2d) (in vitro) (PubMed:16214956, PubMed:19524674, PubMed:21677647, PubMed:25008524, PubMed:26912815, PubMed:27135925, Ref. 11, PubMed:28232581). Does not form functional channels by itself (PubMed:16214956). In vivo, the subunit composition may depend on the expression levels of the different subunits (Probable).
Curated9 PublicationsBinary interactionsi
Hide detailsA0A1L8F5J9
With | #Exp. | IntAct |
---|---|---|
grin2b [A7XY94] | 3 | EBI-15932423,EBI-16113306 |
Isoform 8 [A0A1L8F5J9-8]
With | #Exp. | IntAct |
---|---|---|
Grin2b [Q00960] from Rattus norvegicus. | 6 | EBI-16582829,EBI-396905 |
Protein-protein interaction databases
DIPi | DIP-59169N DIP-61036N |
IntActi | A0A1L8F5J9, 2 interactors |
Structurei
Secondary structure
3D structure databases
SMRi | A0A1L8F5J9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 514 – 516 | Glycine bindingBy similarity | 3 | |
Regioni | 601 – 620 | Pore-forming1 PublicationAdd BLAST | 20 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
OrthoDBi | 188544at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR018882, CaM-bd_C0_NMDA_rcpt_NR1 IPR019594, Glu/Gly-bd IPR001508, Iono_rcpt_met IPR001320, Iontro_rcpt IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF01094, ANF_receptor, 1 hit PF10562, CaM_bdg_C0, 1 hit PF00060, Lig_chan, 1 hit PF10613, Lig_chan-Glu_bd, 1 hit |
PRINTSi | PR00177, NMDARECEPTOR |
SMARTi | View protein in SMART SM00918, Lig_chan-Glu_bd, 1 hit SM00079, PBPe, 1 hit |
SUPFAMi | SSF53822, SSF53822, 1 hit |
s (8)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 8 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGTMRLFLLA VLFLFSFARA GCDPKIVNIG AVLSTKKHEQ IFREAVNQAN
60 70 80 90 100
KRHFTRKIQL NATSVTHRPN AIQMALSVCE DLISSQVYAI LVSHPPAPTD
110 120 130 140 150
HLTPTPISYT AGFYRIPVIG LTTRMSIYSD KSIHLSFLRT VPPYSHQALV
160 170 180 190 200
WFEMMRLFNW NHVILIVSDD HEGRAAQKKL ETLLEEKESK ADKVLQFEPG
210 220 230 240 250
TKNLTALLLE AKELEARVII LSASEDDATA VYKSAAMLDM TGAGYVWLVG
260 270 280 290 300
EREISGSALR YAPDGIIGLQ LINGKNESAH ISDAVAVVAQ AIHELFEMEN
310 320 330 340 350
ITDPPRGCVG NTNIWKTGPL FKRVLMSSKY PDGVTGRIEF NEDGDRKFAN
360 370 380 390 400
YSIMNLQNRK LVQVGIFNGS YIIQNDRKII WPGGETERPQ GYQMSTRLKI
410 420 430 440 450
VTIHQEPFVY VRPTTSDGTC REEYTINGDP IKKVICNGPN ETIPGRPTVP
460 470 480 490 500
QCCYGFCVDL LIKLAREMNF TYEVHLVADG KFGTQERVNN SNKKEWNGMM
510 520 530 540 550
GELLSGQADM IVAPLTINNE RAQYIEFSKP FKYQGLTILV KKEIPRSTLD
560 570 580 590 600
SFMQPFQSTL WLLVGLSVHV VAVMLYLLDR FSPFGRFKVN SEEEEEDALT
610 620 630 640 650
LSSAMWFSWG VLLNSGIGEG APRSFSARIL GMVWAGFAMI IVASYTANLA
660 670 680 690 700
AFLVLDRPEE RITGINDPRL RNPSDKFIYA TVKQSSVDIY FRRQVELSTM
710 720 730 740 750
YRHMEKHNYE SAAEAIQAVR DNKLHAFIWD SAVLEFEASQ KCDLVTTGEL
760 770 780 790 800
FFRSGFGIGM RKDSPWKQNV SLNILKSHEN GFMEELDKTW VRYQECDSRS
810 820 830 840 850
NAPATLTFEN MAGVFMLVAG GIVAGIFLIF IEIAYKRHKD ARRKQMQLAF
860 870 880 890 900
AAVNVWRKNL QDRKSGRAEP DPKKKASFRS ITSTLASSFK RRRSSKDTVN
VVV
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_059206 | 186 – 189 | EKES → GKESKSKKRNYENLDQLSYD NKRGP in isoform 8. | 4 | |
Alternative sequenceiVSP_059207 | 189 | S → SKSKKRNYENLDQLSYDNKR GP in isoform 3, isoform 5 and isoform 6. | 1 | |
Alternative sequenceiVSP_059208 | 862 – 901 | DRKSG…DTVNV → QYPPTDITGQLNLSDPSVST in isoform 6, isoform 7 and isoform 8. Add BLAST | 40 | |
Alternative sequenceiVSP_059209 | 862 – 866 | DRKSG → PGNIK in isoform 4 and isoform 5. | 5 | |
Alternative sequenceiVSP_059210 | 867 – 903 | Missing in isoform 4 and isoform 5. Add BLAST | 37 | |
Alternative sequenceiVSP_059211 | 899 – 901 | VNV → QYPPTDITGQLNLSDPSVST in isoform 2 and isoform 3. | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X94081 mRNA Translation: CAA63825.1 X94156 mRNA Translation: CAA63871.1 DQ066918 mRNA Translation: AAY63890.1 FJ571597 mRNA Translation: ACN87989.1 FJ571598 mRNA Translation: ACN87990.1 FJ571599 mRNA Translation: ACN87991.1 FJ571600 mRNA Translation: ACN87992.1 FJ571601 mRNA Translation: ACN87993.1 CM004480 Genomic DNA Translation: OCT66859.1 |
RefSeqi | NP_001081615.1, NM_001088146.1 [A0A1L8F5J9-8] NP_001081616.1, NM_001088147.1 [A0A1L8F5J9-7] |
Genome annotation databases
GeneIDi | 397953 |
KEGGi | xla:397953 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X94081 mRNA Translation: CAA63825.1 X94156 mRNA Translation: CAA63871.1 DQ066918 mRNA Translation: AAY63890.1 FJ571597 mRNA Translation: ACN87989.1 FJ571598 mRNA Translation: ACN87990.1 FJ571599 mRNA Translation: ACN87991.1 FJ571600 mRNA Translation: ACN87992.1 FJ571601 mRNA Translation: ACN87993.1 CM004480 Genomic DNA Translation: OCT66859.1 |
RefSeqi | NP_001081615.1, NM_001088146.1 [A0A1L8F5J9-8] NP_001081616.1, NM_001088147.1 [A0A1L8F5J9-7] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3QEK | X-ray | 2.00 | A/B | 23-384 | [»] | |
3QEL | X-ray | 2.60 | A/C | 23-384 | [»] | |
3QEM | X-ray | 3.00 | A/C | 23-384 | [»] | |
4TLL | X-ray | 3.59 | A/C | 22-836 | [»] | |
4TLM | X-ray | 3.77 | A/C | 22-836 | [»] | |
5B3J | X-ray | 2.90 | A/B | 23-384 | [»] | |
5EWJ | X-ray | 2.77 | A/C | 23-387 | [»] | |
5EWL | X-ray | 2.98 | A/C | 23-387 | [»] | |
5EWM | X-ray | 2.76 | A/C | 23-387 | [»] | |
5IOU | electron microscopy | 7.00 | A/C | 23-836 | [»] | |
5IOV | electron microscopy | 7.50 | A/C | 23-836 | [»] | |
5IPQ | electron microscopy | 13.50 | A/C | 23-836 | [»] | |
5IPR | electron microscopy | 14.10 | A/C | 23-836 | [»] | |
5IPS | electron microscopy | 13.50 | A/C | 23-836 | [»] | |
5IPT | electron microscopy | 14.10 | A/C | 23-836 | [»] | |
5IPU | electron microscopy | 15.40 | A/C | 23-836 | [»] | |
5IPV | electron microscopy | 9.25 | A/C | 23-836 | [»] | |
5TPW | X-ray | 2.91 | A | 24-387 | [»] | |
5TPZ | X-ray | 3.10 | A | 23-384 | [»] | |
5TQ0 | X-ray | 2.70 | A | 24-387 | [»] | |
5TQ2 | X-ray | 3.29 | A | 24-387 | [»] | |
5UN1 | X-ray | 3.60 | A/C/E/G | 394-836 | [»] | |
5UOW | electron microscopy | 4.50 | A/C | 23-836 | [»] | |
5UP2 | electron microscopy | 6.00 | A/C | 1-836 | [»] | |
6E7R | X-ray | 2.10 | A/C | 23-386 | [»] | |
6E7S | X-ray | 2.72 | A/C | 23-386 | [»] | |
6E7T | X-ray | 2.31 | A/C | 23-386 | [»] | |
6E7U | X-ray | 2.27 | A/C | 23-386 | [»] | |
6E7V | X-ray | 2.60 | A/C | 23-386 | [»] | |
6E7W | X-ray | 2.67 | A/C | 23-386 | [»] | |
6E7X | X-ray | 2.58 | A/C | 23-386 | [»] | |
SMRi | A0A1L8F5J9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-59169N DIP-61036N |
IntActi | A0A1L8F5J9, 2 interactors |
Protein family/group databases
TCDBi | 1.A.10.1.12, the glutamate-gated ion channel (gic) family of neurotransmitter receptors |
PTM databases
iPTMneti | A0A1L8F5J9 |
Protocols and materials databases
ABCDi | A0A1L8F5J9, 1 sequenced antibody |
Genome annotation databases
GeneIDi | 397953 |
KEGGi | xla:397953 |
Organism-specific databases
CTDi | 397953 |
Xenbasei | XB-GENE-866327, grin1.L |
Phylogenomic databases
OrthoDBi | 188544at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR018882, CaM-bd_C0_NMDA_rcpt_NR1 IPR019594, Glu/Gly-bd IPR001508, Iono_rcpt_met IPR001320, Iontro_rcpt IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF01094, ANF_receptor, 1 hit PF10562, CaM_bdg_C0, 1 hit PF00060, Lig_chan, 1 hit PF10613, Lig_chan-Glu_bd, 1 hit |
PRINTSi | PR00177, NMDARECEPTOR |
SMARTi | View protein in SMART SM00918, Lig_chan-Glu_bd, 1 hit SM00079, PBPe, 1 hit |
SUPFAMi | SSF53822, SSF53822, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NMDZ1_XENLA | |
Accessioni | A0A1L8F5J9Primary (citable) accession number: A0A1L8F5J9 Secondary accession number(s): C0KD15 Q91977 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 25, 2017 |
Last sequence update: | March 15, 2017 | |
Last modified: | December 2, 2020 | |
This is version 29 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families