Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 26 (17 Jun 2020)
Sequence version 1 (15 Mar 2017)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Glutamate receptor ionotropic, NMDA 1

Gene

grin1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+ (PubMed:16214956, PubMed:19524674, PubMed:21677647, PubMed:25008524, PubMed:26912815, PubMed:27135925, Ref. 11, PubMed:28232581). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable).Curated8 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Channel activity is modulated by zinc ions. The activity of the heterotetramer with grin2b is stimulated by micromolar levels of Zn2+ (PubMed:19524674). The activity of the heterotetramer with grin2a is inhibited by nanomolar levels of Zn2+ (Ref. 11).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi67Zinc; via tele nitrogen1 Publication1
Metal bindingi94Zinc1 Publication1
Metal bindingi100Zinc1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei521GlycineBy similarity1
Binding sitei686GlycineBy similarity1
Binding sitei730GlycineBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport
LigandCalcium, Magnesium, Metal-binding, Zinc

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.10.1.12 the glutamate-gated ion channel (gic) family of neurotransmitter receptors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutamate receptor ionotropic, NMDA 1
Short name:
GluN1
Alternative name(s):
N-methyl-D-aspartate receptor subunit NR11 Publication
Short name:
NMD-R1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:grin1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000186698 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 8l, Unassembled WGS sequence

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-866327 grin1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 557ExtracellularCuratedAdd BLAST537
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei558 – 578Helical1 PublicationAdd BLAST21
Topological domaini579 – 600CytoplasmicCuratedAdd BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei601 – 622Discontinuously helical1 PublicationAdd BLAST22
Topological domaini623 – 628CytoplasmicCurated6
Transmembranei629 – 645Helical1 PublicationAdd BLAST17
Topological domaini646 – 810ExtracellularCuratedAdd BLAST165
Transmembranei811 – 831Helical1 PublicationAdd BLAST21
Topological domaini832 – 903CytoplasmicCuratedAdd BLAST72

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000044220921 – 903Glutamate receptor ionotropic, NMDA 1Sequence analysisAdd BLAST883

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi61N-linked (GlcNAc...) asparagineCombined sources2 Publications1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi79 ↔ 308Combined sources1 Publication
Glycosylationi203N-linked (GlcNAc...) asparagineCombined sources3 Publications1
Glycosylationi276N-linked (GlcNAc...) asparagineCombined sources3 Publications1
Glycosylationi300N-linked (GlcNAc...) asparagineCombined sources2 Publications1
Glycosylationi350N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi368N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi420 ↔ 452Combined sources1 Publication
Disulfide bondi436 ↔ 453Combined sources1 Publication
Glycosylationi440N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi469N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi489N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi742 ↔ 796Combined sources1 Publication
Glycosylationi769N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Disulfide bond, Glycoprotein

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A0A1L8F5J9

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer (PubMed:27062927). Forms heterotetrameric channels composed of two zeta subunits (grin1), and two epsilon subunits (grin2a, grin2b, grin2c or grin2d) (in vitro) (PubMed:16214956, PubMed:19524674, PubMed:21677647, PubMed:25008524, PubMed:26912815, PubMed:27135925, Ref. 11, PubMed:28232581). Does not form functional channels by itself (PubMed:16214956). In vivo, the subunit composition may depend on the expression levels of the different subunits (Probable).

Curated9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-59169N
DIP-61036N

Protein interaction database and analysis system

More...
IntActi
A0A1L8F5J9, 2 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1903
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A1L8F5J9

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni514 – 516Glycine bindingBy similarity3
Regioni601 – 620Pore-forming1 PublicationAdd BLAST20

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

A hydrophobic region that gives rise to the prediction of a transmembrane span does not cross the membrane, but is part of a discontinuously helical region that dips into the membrane and is probably part of the pore and of the selectivity filter.2 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K05208

Database of Orthologous Groups

More...
OrthoDBi
188544at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR018882 CaM-bd_C0_NMDA_rcpt_NR1
IPR019594 Glu/Gly-bd
IPR001508 Iono_rcpt_met
IPR001320 Iontro_rcpt
IPR028082 Peripla_BP_I

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01094 ANF_receptor, 2 hits
PF10562 CaM_bdg_C0, 1 hit
PF00060 Lig_chan, 1 hit
PF10613 Lig_chan-Glu_bd, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00177 NMDARECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00918 Lig_chan-Glu_bd, 1 hit
SM00079 PBPe, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53822 SSF53822, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A0A1L8F5J9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGTMRLFLLA VLFLFSFARA GCDPKIVNIG AVLSTKKHEQ IFREAVNQAN
60 70 80 90 100
KRHFTRKIQL NATSVTHRPN AIQMALSVCE DLISSQVYAI LVSHPPAPTD
110 120 130 140 150
HLTPTPISYT AGFYRIPVIG LTTRMSIYSD KSIHLSFLRT VPPYSHQALV
160 170 180 190 200
WFEMMRLFNW NHVILIVSDD HEGRAAQKKL ETLLEEKESK ADKVLQFEPG
210 220 230 240 250
TKNLTALLLE AKELEARVII LSASEDDATA VYKSAAMLDM TGAGYVWLVG
260 270 280 290 300
EREISGSALR YAPDGIIGLQ LINGKNESAH ISDAVAVVAQ AIHELFEMEN
310 320 330 340 350
ITDPPRGCVG NTNIWKTGPL FKRVLMSSKY PDGVTGRIEF NEDGDRKFAN
360 370 380 390 400
YSIMNLQNRK LVQVGIFNGS YIIQNDRKII WPGGETERPQ GYQMSTRLKI
410 420 430 440 450
VTIHQEPFVY VRPTTSDGTC REEYTINGDP IKKVICNGPN ETIPGRPTVP
460 470 480 490 500
QCCYGFCVDL LIKLAREMNF TYEVHLVADG KFGTQERVNN SNKKEWNGMM
510 520 530 540 550
GELLSGQADM IVAPLTINNE RAQYIEFSKP FKYQGLTILV KKEIPRSTLD
560 570 580 590 600
SFMQPFQSTL WLLVGLSVHV VAVMLYLLDR FSPFGRFKVN SEEEEEDALT
610 620 630 640 650
LSSAMWFSWG VLLNSGIGEG APRSFSARIL GMVWAGFAMI IVASYTANLA
660 670 680 690 700
AFLVLDRPEE RITGINDPRL RNPSDKFIYA TVKQSSVDIY FRRQVELSTM
710 720 730 740 750
YRHMEKHNYE SAAEAIQAVR DNKLHAFIWD SAVLEFEASQ KCDLVTTGEL
760 770 780 790 800
FFRSGFGIGM RKDSPWKQNV SLNILKSHEN GFMEELDKTW VRYQECDSRS
810 820 830 840 850
NAPATLTFEN MAGVFMLVAG GIVAGIFLIF IEIAYKRHKD ARRKQMQLAF
860 870 880 890 900
AAVNVWRKNL QDRKSGRAEP DPKKKASFRS ITSTLASSFK RRRSSKDTVN

VVV
Length:903
Mass (Da):101,793
Last modified:March 15, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE2612938C9125D76
GO
Isoform 2 (identifier: A0A1L8F5J9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     899-901: VNV → QYPPTDITGQLNLSDPSVST

Show »
Length:920
Mass (Da):103,596
Checksum:iCF2631A4826597F5
GO
Isoform 3 (identifier: A0A1L8F5J9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     189-189: S → SKSKKRNYENLDQLSYDNKRGP
     899-901: VNV → QYPPTDITGQLNLSDPSVST

Show »
Length:941
Mass (Da):106,132
Checksum:iF2291DCD2C0E9925
GO
Isoform 4 (identifier: A0A1L8F5J9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     862-866: DRKSG → PGNIK
     867-903: Missing.

Show »
Length:866
Mass (Da):97,626
Checksum:i4A11A43A122EE867
GO
Isoform 5 (identifier: A0A1L8F5J9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     189-189: S → SKSKKRNYENLDQLSYDNKRGP
     862-866: DRKSG → PGNIK
     867-903: Missing.

Show »
Length:887
Mass (Da):100,162
Checksum:i5D4C46D99603128F
GO
Isoform 6 (identifier: A0A1L8F5J9-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     189-189: S → SKSKKRNYENLDQLSYDNKRGP
     862-901: DRKSGRAEPDPKKKASFRSITSTLASSFKRRRSSKDTVNV → QYPPTDITGQLNLSDPSVST

Show »
Length:904
Mass (Da):101,966
Checksum:i8ACCA847F88D4A9D
GO
Isoform 7 (identifier: A0A1L8F5J9-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     862-901: DRKSGRAEPDPKKKASFRSITSTLASSFKRRRSSKDTVNV → QYPPTDITGQLNLSDPSVST

Show »
Length:883
Mass (Da):99,430
Checksum:iE46FE8F7CA85F883
GO
Isoform 8 (identifier: A0A1L8F5J9-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     186-189: EKES → GKESKSKKRNYENLDQLSYDNKRGP
     862-901: DRKSGRAEPDPKKKASFRSITSTLASSFKRRRSSKDTVNV → QYPPTDITGQLNLSDPSVST

Show »
Length:904
Mass (Da):101,894
Checksum:i46D8FE0EA6D903F2
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_059206186 – 189EKES → GKESKSKKRNYENLDQLSYD NKRGP in isoform 8. 4
Alternative sequenceiVSP_059207189S → SKSKKRNYENLDQLSYDNKR GP in isoform 3, isoform 5 and isoform 6. 1
Alternative sequenceiVSP_059208862 – 901DRKSG…DTVNV → QYPPTDITGQLNLSDPSVST in isoform 6, isoform 7 and isoform 8. Add BLAST40
Alternative sequenceiVSP_059209862 – 866DRKSG → PGNIK in isoform 4 and isoform 5. 5
Alternative sequenceiVSP_059210867 – 903Missing in isoform 4 and isoform 5. Add BLAST37
Alternative sequenceiVSP_059211899 – 901VNV → QYPPTDITGQLNLSDPSVST in isoform 2 and isoform 3. 3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X94081 mRNA Translation: CAA63825.1
X94156 mRNA Translation: CAA63871.1
DQ066918 mRNA Translation: AAY63890.1
FJ571597 mRNA Translation: ACN87989.1
FJ571598 mRNA Translation: ACN87990.1
FJ571599 mRNA Translation: ACN87991.1
FJ571600 mRNA Translation: ACN87992.1
FJ571601 mRNA Translation: ACN87993.1
CM004480 Genomic DNA Translation: OCT66859.1

NCBI Reference Sequences

More...
RefSeqi
NP_001081615.1, NM_001088146.1 [A0A1L8F5J9-8]
NP_001081616.1, NM_001088147.1 [A0A1L8F5J9-7]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
397953

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:397953

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94081 mRNA Translation: CAA63825.1
X94156 mRNA Translation: CAA63871.1
DQ066918 mRNA Translation: AAY63890.1
FJ571597 mRNA Translation: ACN87989.1
FJ571598 mRNA Translation: ACN87990.1
FJ571599 mRNA Translation: ACN87991.1
FJ571600 mRNA Translation: ACN87992.1
FJ571601 mRNA Translation: ACN87993.1
CM004480 Genomic DNA Translation: OCT66859.1
RefSeqiNP_001081615.1, NM_001088146.1 [A0A1L8F5J9-8]
NP_001081616.1, NM_001088147.1 [A0A1L8F5J9-7]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QEKX-ray2.00A/B23-384[»]
3QELX-ray2.60A/C23-384[»]
3QEMX-ray3.00A/C23-384[»]
4TLLX-ray3.59A/C22-836[»]
4TLMX-ray3.77A/C22-836[»]
5B3JX-ray2.90A/B23-384[»]
5EWJX-ray2.77A/C23-387[»]
5EWLX-ray2.98A/C23-387[»]
5EWMX-ray2.76A/C23-387[»]
5IOUelectron microscopy7.00A/C23-836[»]
5IOVelectron microscopy7.50A/C23-836[»]
5IPQelectron microscopy13.50A/C23-836[»]
5IPRelectron microscopy14.10A/C23-836[»]
5IPSelectron microscopy13.50A/C23-836[»]
5IPTelectron microscopy14.10A/C23-836[»]
5IPUelectron microscopy15.40A/C23-836[»]
5IPVelectron microscopy9.25A/C23-836[»]
5TPWX-ray2.91A24-387[»]
5TPZX-ray3.10A23-384[»]
5TQ0X-ray2.70A24-387[»]
5TQ2X-ray3.29A24-387[»]
5UN1X-ray3.60A/C/E/G394-836[»]
5UOWelectron microscopy4.50A/C23-836[»]
5UP2electron microscopy6.00A/C1-836[»]
6E7RX-ray2.10A/C23-386[»]
6E7SX-ray2.72A/C23-386[»]
6E7TX-ray2.31A/C23-386[»]
6E7UX-ray2.27A/C23-386[»]
6E7VX-ray2.60A/C23-386[»]
6E7WX-ray2.67A/C23-386[»]
6E7XX-ray2.58A/C23-386[»]
SMRiA0A1L8F5J9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-59169N
DIP-61036N
IntActiA0A1L8F5J9, 2 interactors

Protein family/group databases

TCDBi1.A.10.1.12 the glutamate-gated ion channel (gic) family of neurotransmitter receptors

PTM databases

iPTMnetiA0A1L8F5J9

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
A0A1L8F5J9 1 sequenced antibody

Genome annotation databases

GeneIDi397953
KEGGixla:397953

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
397953
XenbaseiXB-GENE-866327 grin1

Phylogenomic databases

KOiK05208
OrthoDBi188544at2759

Family and domain databases

InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR018882 CaM-bd_C0_NMDA_rcpt_NR1
IPR019594 Glu/Gly-bd
IPR001508 Iono_rcpt_met
IPR001320 Iontro_rcpt
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF01094 ANF_receptor, 2 hits
PF10562 CaM_bdg_C0, 1 hit
PF00060 Lig_chan, 1 hit
PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSiPR00177 NMDARECEPTOR
SMARTiView protein in SMART
SM00918 Lig_chan-Glu_bd, 1 hit
SM00079 PBPe, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNMDZ1_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1L8F5J9
Secondary accession number(s): C0KD15
, C0KD16, C0KD17, C0KD18, C0KD19, Q4PLR7, Q91805, Q91977
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2017
Last sequence update: March 15, 2017
Last modified: June 17, 2020
This is version 26 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again