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Entry version 15 (02 Jun 2021)
Sequence version 1 (15 Mar 2017)
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Protein

Microtubule-associated protein

Gene

XELAEV_18044881mg

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule-associated proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:XELAEV_18044881mgImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000186698 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9_10l

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, CytoskeletonUniRule annotation, MicrotubuleUniRule annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini306 – 1419MAP2_projctnInterPro annotationAdd BLAST1114

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni13 – 127DisorderedSequence analysisAdd BLAST115
Regioni147 – 191DisorderedSequence analysisAdd BLAST45
Regioni382 – 500DisorderedSequence analysisAdd BLAST119
Regioni687 – 722DisorderedSequence analysisAdd BLAST36
Regioni936 – 979DisorderedSequence analysisAdd BLAST44
Regioni1038 – 1192DisorderedSequence analysisAdd BLAST155
Regioni1232 – 1292DisorderedSequence analysisAdd BLAST61
Regioni1319 – 1569DisorderedSequence analysisAdd BLAST251
Regioni1718 – 1741DisorderedSequence analysisAdd BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili985 – 1005Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi70 – 88Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi94 – 112Polar residuesSequence analysisAdd BLAST19
Compositional biasi147 – 162Polar residuesSequence analysisAdd BLAST16
Compositional biasi163 – 191Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi394 – 409Polar residuesSequence analysisAdd BLAST16
Compositional biasi429 – 462Basic and acidic residuesSequence analysisAdd BLAST34
Compositional biasi475 – 492Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi936 – 955Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1038 – 1075Basic and acidic residuesSequence analysisAdd BLAST38
Compositional biasi1085 – 1099Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1135 – 1172Basic and acidic residuesSequence analysisAdd BLAST38
Compositional biasi1274 – 1292Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi1319 – 1393Basic and acidic residuesSequence analysisAdd BLAST75
Compositional biasi1430 – 1445Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1471 – 1544Polar residuesSequence analysisAdd BLAST74
Compositional biasi1722 – 1741Polar residuesSequence analysisAdd BLAST20

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
FIEMPME

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030797, MAP2
IPR013588, MAP2_projctn
IPR001084, MAP_tubulin-bd_rpt

The PANTHER Classification System

More...
PANTHERi
PTHR11501:SF15, PTHR11501:SF15, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08377, MAP2_projctn, 1 hit
PF00418, Tubulin-binding, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00229, TAU_MAP_1, 1 hit
PS51491, TAU_MAP_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1L8EWQ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPFPVHHLDK KVPYLFGGRG SMTDNRQDEP KATHWAPGQL SEASPLPHAT
60 70 80 90 100
DMKEQGGAGE GMVHSSNGIP FREAEERAYG ERDLPASHSA GKENGINGEM
110 120 130 140 150
SSADSAAVED TTNLPPSPPP SPASEQMGTI EEDLLTASKI AAQETLESTP
160 170 180 190 200
LSVEAIHSVE DSSPTKSGKD IKQDTLDLHT PEIEDKRLPP MPLEEITSGQ
210 220 230 240 250
IGFEPHHVHT FSIEPCTPTS PNVPKHNLYD IPDESLTLEW STIQDTSKDS
260 270 280 290 300
SMRDKDDFSA TEKNIEAEIP ISTLTINESE IPLSLDKAEG HHTEDEFSSH
310 320 330 340 350
TDSVLKDLPN IANTELSNNA SASTVDTYRG EHVLSDEQDV ISEKPNLDSM
360 370 380 390 400
PSTLVSSNLS NEAYQADVKD DGDVMSDVLK SHSTDAIAVP PKQYETDTSK
410 420 430 440 450
SSDSAVQSKD TVTKESDKIS LDSEVEGPIS PKESAKVDEE FVSDSYDATK
460 470 480 490 500
KNDKDLLEAT EMKGEMSELP LENVISQLKD EKETEEQKSP VSEDKSGMST
510 520 530 540 550
YFETSALKEE IDREIQQSSD YYELTDVKEP QYEACSIPHI AKEEEDEESG
560 570 580 590 600
DLEQVTKEKV STSAHEVGYS TLTSGKLQAS IYSGDRLFTI DPNIYADKSE
610 620 630 640 650
FLSKNKDDLT LSRSLGLGGR SAIEQRSMSI NLPMSCLDSI ALGFSYARAH
660 670 680 690 700
DLSPLATDIL SNTSGSMDEG DDSDLPATTP ALEKAISFPE EQEHKRAEEE
710 720 730 740 750
EEEEENNDAE KSTEKETFEL EPLCESDYQA KEYYKNGTIM APDLPEMLDL
760 770 780 790 800
TGSRSRLDSA SADSETARRK SGISEIIIDE SCVLQESTIE GSNLLVKTDS
810 820 830 840 850
QQEEFGYCVF NKYTVPLPSP VQDSESLGGG MSTLYESLAV DPSIIQVKLA
860 870 880 890 900
AAEKFGIEGQ DISSETVCWE AELEKKVSEI KLDTVVEKSE EQSDLKEVSE
910 920 930 940 950
IADFIKPEST DTPLKEKIEG PEEELCIAQF DKKSVEESGE QFPQETEERK
960 970 980 990 1000
SSPADISGAE IEAPSEKAMV SAEDTQSNLE TSELIKDASH LKNEIQEKIG
1010 1020 1030 1040 1050
IAEEDNAIEL DSSLIKDIKE TDVEEVTVSK DETKLLESDL KEKGAKPDLV
1060 1070 1080 1090 1100
HQEAMDKEES YESSGEHEQS QEPADEVSKD TSLVCADVQK EDKEDTAPES
1110 1120 1130 1140 1150
QMETQIMISS KDDLKEEEAD EMQTECLSEP QDEQVVEVSV EKEMPKEEIQ
1160 1170 1180 1190 1200
QQLDEEYDED RNKTKETGDN EITSDAPEQE TEAQVPNEEP AVVFTDDVVE
1210 1220 1230 1240 1250
VIESVVTVDE GFIQVVQTAV DDSEIMAHSV RFATSMPVES EEKPEIEEDI
1260 1270 1280 1290 1300
EEAKDEPREG SPCAPASPQK EDTLFTDYKT ETQDDYRDET TIDDSVLDTD
1310 1320 1330 1340 1350
SIWVDTQDDD RSIMTEAIEA IPKEEKAERD LQRTSTEKYR KEKPLKSGRA
1360 1370 1380 1390 1400
RMSTPERKMA KKEPSATCRD EVRRKKAVLK KAETAKKTDV QPHSPSRKII
1410 1420 1430 1440 1450
LKPAVRQSRP THLSCVRRKP AGGESQQTPS AHRHPRDRTM DGVSKSPEKR
1460 1470 1480 1490 1500
SSLPRPSSIH PIRKVYPDKE DNSFSTSTSV SSSVRRTTRS EPIWSRTGKS
1510 1520 1530 1540 1550
GTSTPTTPGS TAITPGTPPS YASRTPGTPG TPSYSRTPRT PGTPKSALLY
1560 1570 1580 1590 1600
SEKKVAVLRT PPKSPSTPKQ IRIMNQPLPD LKSIRSKIGS IDNIKYQPKG
1610 1620 1630 1640 1650
GQVKILSEKI DYSDVQSRCG SKDNITHNAG GGQIQIVSKK IDLSHVTSKC
1660 1670 1680 1690 1700
GSLRKIRHRP GGGNVRIESV KLDFKDKAHA KVGSLDNAHH TPGGGNIKID
1710 1720 1730 1740 1750
SQKLHFREQA KARVDHGAEI ISQSPGRSSA ASPRRLSNVS SSGSINLLES
1760
PQLATLAEDV TAALAKQGL
Length:1,769
Mass (Da):194,595
Last modified:March 15, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC6CBEC1BC77A9980
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CM004482 Genomic DNA Translation: OCT63784.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM004482 Genomic DNA Translation: OCT63784.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Phylogenomic databases

OMAiFIEMPME

Family and domain databases

InterProiView protein in InterPro
IPR030797, MAP2
IPR013588, MAP2_projctn
IPR001084, MAP_tubulin-bd_rpt
PANTHERiPTHR11501:SF15, PTHR11501:SF15, 2 hits
PfamiView protein in Pfam
PF08377, MAP2_projctn, 1 hit
PF00418, Tubulin-binding, 4 hits
PROSITEiView protein in PROSITE
PS00229, TAU_MAP_1, 1 hit
PS51491, TAU_MAP_2, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1L8EWQ3_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1L8EWQ3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 15, 2017
Last sequence update: March 15, 2017
Last modified: June 2, 2021
This is version 15 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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