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Protein
Submitted name:

MHC class II antigen

Gene

HLA-DRB1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class II antigenImported
Gene namesi
Name:HLA-DRB1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, MHC IISAAS annotation

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

SMRiA0A1L7H6X3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 180Ig-likeInterPro annotationAdd BLAST89

Sequence similaritiesi

Belongs to the MHC class II family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR000353 MHC_II_b_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00969 MHC_II_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000328 MHC_II_b_N, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00921 MHC_II_beta, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Fragment.

A0A1L7H6X3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RFLEYSTSEC HFFNGTERVR FLDRYFYNQE EYVRFDSDVG EFRAVTELGR
60 70 80 90 100
PDEEYWNSQK DFLEDRRAAV DTYCRHNYGV GESFTVQRRV HPKVTVYPSK
110 120 130 140 150
TQPLQHHNLL VCSVSGFYPG SIEVRWFRNG QEEKTGVVST GLIHNGDWTF
160 170 180
QTLVMLETVP RSGEVYTCQV EHPSVTSPLT VEW
Length:183
Mass (Da):21,465
Last modified:March 15, 2017 - v1
Checksum:i50A0FE723F09A798
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei183Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KX170857 Genomic DNA Translation: APU50637.1

Similar proteinsi

Entry informationi

Entry nameiA0A1L7H6X3_HUMAN
AccessioniPrimary (citable) accession number: A0A1L7H6X3
Entry historyiIntegrated into UniProtKB/TrEMBL: March 15, 2017
Last sequence update: March 15, 2017
Last modified: February 28, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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