UniProtKB - A0A1L1SSL9 (A0A1L1SSL9_MOUSE)
Protein
Non-specific serine/threonine protein kinase
Gene
Atr
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- MutLalpha complex binding Source: Ensembl
- MutSalpha complex binding Source: Ensembl
- protein serine/threonine kinase activity Source: Ensembl
GO - Biological processi
- cellular response to gamma radiation Source: Ensembl
- cellular response to UV Source: Ensembl
- DNA damage checkpoint Source: Ensembl
- DNA repair Source: UniProtKB-KW
- establishment of RNA localization to telomere Source: Ensembl
- negative regulation of DNA replication Source: Ensembl
- peptidyl-serine phosphorylation Source: Ensembl
- positive regulation of DNA damage response, signal transduction by p53 class mediator Source: Ensembl
- positive regulation of telomerase catalytic core complex assembly Source: Ensembl
- protein autophosphorylation Source: Ensembl
- protein localization to chromosome, telomeric region Source: Ensembl
- replicative senescence Source: Ensembl
- response to drug Source: Ensembl
Keywordsi
Molecular function | KinasePROSITE-ProRule annotationARBA annotation, Transferase |
Biological process | DNA damage, DNA repairARBA annotation |
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation) |
Gene namesi | Name:AtrImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:108028, Atr |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Golgi apparatus
- Golgi apparatus Source: Ensembl
Nucleus
- PML body Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 805 – 839 | HEATPROSITE-ProRule annotationAdd BLAST | 35 | |
Domaini | 1640 – 2185 | FATInterPro annotationAdd BLAST | 546 | |
Domaini | 2319 – 2641 | PI3K/PI4KInterPro annotationAdd BLAST | 323 | |
Domaini | 2609 – 2641 | FATCInterPro annotationAdd BLAST | 33 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 423 – 447 | DisorderedSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00940000155714 |
OMAi | WMLLPHF |
OrthoDBi | 80538at2759 |
Family and domain databases
Gene3Di | 1.10.1070.11, 1 hit 1.25.10.10, 2 hits 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR003152, FATC_dom IPR021133, HEAT_type_2 IPR011009, Kinase-like_dom_sf IPR000403, PI3/4_kinase_cat_dom IPR036940, PI3/4_kinase_cat_sf IPR018936, PI3/4_kinase_CS IPR003151, PIK-rel_kinase_FAT IPR014009, PIK_FAT IPR011990, TPR-like_helical_dom_sf IPR012993, UME |
Pfami | View protein in Pfam PF02259, FAT, 1 hit PF02260, FATC, 1 hit PF00454, PI3_PI4_kinase, 1 hit PF08064, UME, 1 hit |
SMARTi | View protein in SMART SM01343, FATC, 1 hit SM00146, PI3Kc, 1 hit SM00802, UME, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF48452, SSF48452, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51189, FAT, 1 hit PS51190, FATC, 1 hit PS50077, HEAT_REPEAT, 1 hit PS00916, PI3_4_KINASE_2, 1 hit PS50290, PI3_4_KINASE_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
A0A1L1SSL9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGDHGLELAS MIPALRELAS ATPEEYNTVV QKPRQILCQF IDRILTDVNV
60 70 80 90 100
VALELVKKTD AQPTSVMLLD FIQHIMKSSP LMFVNVNGSQ GQNEAKDSCI
110 120 130 140 150
EFSHWIITRL LRIAATPSCH MLHKKICEVI CSLLFLFKSK NPAIFGVLTR
160 170 180 190 200
ELLYLFEDLI YLHKRNAVGE VMEWPVVVSR FLSRLDEHMG CLQPAPLQFM
210 220 230 240 250
NVQNVEFIEV TLLMVLIHIV PTVFFRRQEL LLWQIGCALL EHGSPKIRSL
260 270 280 290 300
AISLLTELFE LGGLPAQPAS TFFSLFLELL QHLVGMDADQ LKLYEEPLSK
310 320 330 340 350
LLKTLFPFEA EAYRNIEPVY LNVLLEKLSV MFEDRVLMRL KSDLLKAALC
360 370 380 390 400
HLLQYFLTFV PAGYESALQV RKVYVTNICR ALVDALGVQK HVGYLLGPFY
410 420 430 440 450
AALKMESKEI IERIQCQAQQ ENLSGNNDEV SPKRRKLSSS LSSYKKPSRQ
460 470 480 490 500
PEEIIHVDMD KKSILWNVLK QKAESLQISL ECGTLKNSVA EALEGITVVL
510 520 530 540 550
QLTALCTVHC SHQDMDGHNV KDHQHKYKKK PPVVVTWMSL DFYTKVLKSC
560 570 580 590 600
RSLLESVQKL ELELVIDSMV RICDALMYMQ VKSSFKDHVL EELCGMLSLP
610 620 630 640 650
WIYSYSDDNS LKMTTFATNL LPLSQRVWDS YSPQAQSKCV FLLTLFPRRI
660 670 680 690 700
FLEWRTAVYN WALKSSHEVI RASCVKGFFI LLHQQNSCNQ IPKMLVDRVK
710 720 730 740 750
DDSDMVKKEF ASVLGQLVCT LHGMFYLSSS VEPCFEHMDL FSKNLKATSQ
760 770 780 790 800
HECSSSQVKA STCKPFLFLL TKNTPSPVKL AFIDNLHHLC KHLDFQEDER
810 820 830 840 850
EVKAVLGTLL NLMEDPDKDV RIAFSGNIKY ILESLNSEDG FVKELFVLRM
860 870 880 890 900
KEAYTHAQIA RNNELKDTLI LTTGDIGRAA KGDLIPFALL HLLHCLLSKS
910 920 930 940 950
ASVSGAAYTE IRALVAAKSV KLQNFFSQYK KPICQFLVES LHSSQMTALP
960 970 980 990 1000
SAPCQSSEIR KQDVAHHREM ALNTLSEIAN VFDFPDLNRF LTRTLQVLLP
1010 1020 1030 1040 1050
DLAAKASPAA SALIRTLGKQ LNVSRREILI NNFKYIFSHL VCSCSKDELE
1060 1070 1080 1090 1100
RALHYLKNET EIELGSLLRQ DFQGLHNELL LRIGEHYQQV FNGLSILASF
1110 1120 1130 1140 1150
ASSDDPYQGP RDITSPELMA DYLQPKLLGI LAFFNMQLLS SSVGIEDKKM
1160 1170 1180 1190 1200
ALTSLMSLMK LMGPKHVSSV RVKMMTTLRT GLRFKDDFPE LCCRAWDCFV
1210 1220 1230 1240 1250
RCLDHAYLGP LLSHVIVALL PLIHMQPKET AAIFHYLIIE NRDAVQDFLH
1260 1270 1280 1290 1300
EIYFLPDHPE LEKIKAVLQE YRKETSETTD LQTTLQLSMK AIQHENVDVR
1310 1320 1330 1340 1350
IHALTSLKET LYKNQEKLIK YATDSETVEP VISQLVTVIL KGCQDANSQA
1360 1370 1380 1390 1400
RLLCGECLGE LGAIDPGRLD FSTTETQGKD FTFVTGVEDL SFAYGLLMEL
1410 1420 1430 1440 1450
TRAYLAYADN SRAQDSAAYA IQELLSIYDC REMQSNGPGY QLWKRFPEHV
1460 1470 1480 1490 1500
REILEPHLNT RYKSSQKSTD WSGVTKPIYL SKLGNNFAEW SSSWAGYLIT
1510 1520 1530 1540 1550
KVRDNLASKI FTCCSIMMKH DFKVTIYLLP HILVYVLLGC NQEDQQEVYA
1560 1570 1580 1590 1600
EIMAVLKHDE QHAISTQDSA SDLCQLSTQT VFSVLDHLTQ WARHKFQALN
1610 1620 1630 1640 1650
AEKLAQNKPK GGKVNKILSN VNFEDYQSVT RFLDLIPQDT LAVASFRSKA
1660 1670 1680 1690 1700
YTRAVMHFES FITEKKQNIQ KHLGFLQKLY AAMHEPDGVA GVSAIRKAEP
1710 1720 1730 1740 1750
SLKEQILEHE SIGLLRDATA CYDRAIQLEP DQIIHYHGVV KSMLGLGQLS
1760 1770 1780 1790 1800
TVITQVNGVH ANRSEWTDEL NTYRVEAAWK LSQWDLVENY LAADGKSTTW
1810 1820 1830 1840 1850
SVRLGQLLLS AKKRDTTTFY DTLKLVRAEQ IVPLSAASFE RGSYQRGYEF
1860 1870 1880 1890 1900
IVRLHMLCEL EHSLKPLFRK SPGDSCNEDS LNWGARLEMT QNSYRAKEPI
1910 1920 1930 1940 1950
LALRRALLSL NKRPDYNEMV GECWLQSARV ARKAGHHQTA YNALLNAGES
1960 1970 1980 1990 2000
RLAELYVERA KWLWSKGDVH QALIVLQKGV ELCFPENKSP SESKHMLIHG
2010 2020 2030 2040 2050
RATLLVGRFM EETANFESNA VMKKYKDVTL FLPEWEDGHF YLAKYYDKLM
2060 2070 2080 2090 2100
PMVTDNKMEK QGDLIRYIVL HFGRSLQYGN QFIYQSMPRM LSLWLDFGAK
2110 2120 2130 2140 2150
AYEWEKGGRS DRLQMRNDLA KINSVLTEHT NRLAPYQFLT AFSQLISRIC
2160 2170 2180 2190 2200
HSHDEVFVVL MEIIAKVFLA YPQQAMWMMT AVSKSSYPMR VNRCKEILTK
2210 2220 2230 2240 2250
AIHMKKSLEK FVGDATRLTD KLLELCNKSV DGSNSTLSMS THFKMLKRLV
2260 2270 2280 2290 2300
EDPTFSEILI PLQSVMIPTL PSVLGAHANH DPFPGHWAYL AGFDDVVEIL
2310 2320 2330 2340 2350
SSLQKPKKIS LKGSDGKFYI MMCKPKDDLR KDCRLMEFNS LINKSLRKDA
2360 2370 2380 2390 2400
ESRRRELHIR TYAVIPLNDE CGIIEWVNNT AGLRPILTKI YKEKGVYMTG
2410 2420 2430 2440 2450
KELRQCMLPK SAALSEKLKV FQELLLPRHP PVFHEWFLRT FPDPTSWYSS
2460 2470 2480 2490 2500
RSAYCRSTAV MSMVGYILGL GDRHGENILF DSFTGECVHV DFNCLFNKGE
2510 2520 2530 2540 2550
TFEVPEIVPF RLTHNMVNGM GPMGTEGLFR RACEVTLRLM RDQREPLMSV
2560 2570 2580 2590 2600
LKTFLHDPLV EWSKPVKGHS KAPLNETGEV VNEKAKTHVL DIEQRLQGVI
2610 2620 2630 2640
KTRNRVTGLP LSIEGHVHYL IQEATDENLL CQMYLGWTPY M
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9JKK8 | ATR_MOUSE | Serine/threonine-protein kinase ATR | Atr Kiaa4069 | 2,635 | Annotation score: | ||
E9QPK4 | E9QPK4_MOUSE | Non-specific serine/threonine prote... | Atr | 2,635 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC091531 Genomic DNA No translation available. AC121499 Genomic DNA No translation available. |
RefSeqi | NP_063917.1, NM_019864.1 |
Genome annotation databases
Ensembli | ENSMUST00000215311; ENSMUSP00000149953; ENSMUSG00000032409 |
GeneIDi | 245000 |
KEGGi | mmu:245000 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC091531 Genomic DNA No translation available. AC121499 Genomic DNA No translation available. |
RefSeqi | NP_063917.1, NM_019864.1 |
3D structure databases
SMRi | A0A1L1SSL9 |
ModBasei | Search... |
Proteomic databases
MaxQBi | A0A1L1SSL9 |
Protocols and materials databases
Antibodypediai | 18078, 511 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000215311; ENSMUSP00000149953; ENSMUSG00000032409 |
GeneIDi | 245000 |
KEGGi | mmu:245000 |
Organism-specific databases
CTDi | 545 |
MGIi | MGI:108028, Atr |
Phylogenomic databases
GeneTreei | ENSGT00940000155714 |
OMAi | WMLLPHF |
OrthoDBi | 80538at2759 |
Miscellaneous databases
BioGRID-ORCSi | 245000, 7 hits in 20 CRISPR screens |
ChiTaRSi | Atr, mouse |
SOURCEi | Search... |
Gene expression databases
ExpressionAtlasi | A0A1L1SSL9, baseline and differential |
Family and domain databases
Gene3Di | 1.10.1070.11, 1 hit 1.25.10.10, 2 hits 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR003152, FATC_dom IPR021133, HEAT_type_2 IPR011009, Kinase-like_dom_sf IPR000403, PI3/4_kinase_cat_dom IPR036940, PI3/4_kinase_cat_sf IPR018936, PI3/4_kinase_CS IPR003151, PIK-rel_kinase_FAT IPR014009, PIK_FAT IPR011990, TPR-like_helical_dom_sf IPR012993, UME |
Pfami | View protein in Pfam PF02259, FAT, 1 hit PF02260, FATC, 1 hit PF00454, PI3_PI4_kinase, 1 hit PF08064, UME, 1 hit |
SMARTi | View protein in SMART SM01343, FATC, 1 hit SM00146, PI3Kc, 1 hit SM00802, UME, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF48452, SSF48452, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51189, FAT, 1 hit PS51190, FATC, 1 hit PS50077, HEAT_REPEAT, 1 hit PS00916, PI3_4_KINASE_2, 1 hit PS50290, PI3_4_KINASE_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A1L1SSL9_MOUSE | |
Accessioni | A0A1L1SSL9Primary (citable) accession number: A0A1L1SSL9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 15, 2017 |
Last sequence update: | February 15, 2017 | |
Last modified: | December 2, 2020 | |
This is version 29 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |