UniProtKB - A0A1L1SSH9 (A0A1L1SSH9_MOUSE)
Protein
Osteonectin
Gene
Sparc
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- calcium ion binding Source: InterPro
- collagen binding Source: InterPro
Keywordsi
Ligand | CopperARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: OsteonectinARBA annotationAlternative name(s): SPARCARBA annotation Secreted protein acidic and rich in cysteineARBA annotation |
Gene namesi | Name:SparcImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98373, Sparc |
Subcellular locationi
Extracellular region or secreted
- basement membrane ARBA annotation
Other locations
- Membrane ARBA annotation
Extracellular region or secreted
- basement membrane Source: UniProtKB-SubCell
- extracellular space Source: InterPro
Other locations
- membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Basement membraneARBA annotation, Extracellular matrix, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 47 | Sequence analysisAdd BLAST | 47 | |
ChainiPRO_5015066558 | 48 – 332 | OsteonectinSequence analysisAdd BLAST | 285 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 101 ↔ 112 | UniRule annotation | ||
Disulfide bondi | 106 ↔ 122 | UniRule annotation | ||
Disulfide bondi | 124 ↔ 159 | UniRule annotation | ||
Disulfide bondi | 130 ↔ 152 | UniRule annotation | ||
Disulfide bondi | 141 ↔ 178 | UniRule annotation | ||
Disulfide bondi | 184 ↔ 294 | UniRule annotation | ||
Disulfide bondi | 302 ↔ 318 | UniRule annotation |
Keywords - PTMi
Disulfide bondUniRule annotation, GlycoproteinARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 123 – 180 | Kazal-likeInterPro annotationAdd BLAST | 58 |
Sequence similaritiesi
Belongs to the SPARC family.ARBA annotation
Keywords - Domaini
SignalSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00510000046787 |
Family and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR003645, Fol_N IPR015369, Follistatin/Osteonectin_EGF IPR002350, Kazal_dom IPR036058, Kazal_dom_sf IPR001999, Osteonectin_CS IPR037641, SPARC IPR019577, SPARC/Testican_Ca-bd-dom |
PANTHERi | PTHR13866:SF6, PTHR13866:SF6, 1 hit |
Pfami | View protein in Pfam PF09289, FOLN, 1 hit PF00050, Kazal_1, 1 hit PF10591, SPARC_Ca_bdg, 1 hit |
SMARTi | View protein in SMART SM00274, FOLN, 1 hit SM00280, KAZAL, 1 hit |
SUPFAMi | SSF100895, SSF100895, 1 hit SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS51465, KAZAL_2, 1 hit PS00612, OSTEONECTIN_1, 1 hit PS00613, OSTEONECTIN_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
A0A1L1SSH9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRQPFRPPEL FCRLPACLPA CLPVPRVPSI MRAWIFFLLC LAGRALAAPQ
60 70 80 90 100
QTEVAEEIVE EETVVEETGV PVGANPVQVE MGEFEDGAEE TVEEVVADNP
110 120 130 140 150
CQNHHCKHGK VCELDESNTP MCVCQDPTSC PAPIGEFEKV CSNDNKTFDS
160 170 180 190 200
SCHFFATKCT LEGTKKGHKL HLDYIGPCKY IAPCLDSELT EFPLRMRDWL
210 220 230 240 250
KNVLVTLYER DEGNNLLTEK QKLRVKKIHE NEKRLEAGDH PVELLARDFE
260 270 280 290 300
KNYNMYIFPV HWQFGQLDQH PIDGYLSHTE LAPLRAPLIP MEHCTTRFFE
310 320 330
TCDLDNDKYI ALEEWAGCFG IKEQDINKDL VI
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP07214 | SPRC_MOUSE | SPARC | Sparc | 302 | Annotation score: | ||
Q5NCU4 | Q5NCU4_MOUSE | Osteonectin | Sparc | 301 | Annotation score: | ||
Q5NCU3 | Q5NCU3_MOUSE | Osteonectin | Sparc | 172 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL596207 Genomic DNA No translation available. AL772268 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSMUST00000213866; ENSMUSP00000149604; ENSMUSG00000018593 ENSMUST00000216313; ENSMUSP00000149918; ENSMUSG00000018593 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL596207 Genomic DNA No translation available. AL772268 Genomic DNA No translation available. |
3D structure databases
SMRi | A0A1L1SSH9 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 878, 758 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000213866; ENSMUSP00000149604; ENSMUSG00000018593 ENSMUST00000216313; ENSMUSP00000149918; ENSMUSG00000018593 |
Organism-specific databases
MGIi | MGI:98373, Sparc |
Phylogenomic databases
GeneTreei | ENSGT00510000046787 |
Miscellaneous databases
ChiTaRSi | Sparc, mouse |
SOURCEi | Search... |
Gene expression databases
ExpressionAtlasi | A0A1L1SSH9, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR003645, Fol_N IPR015369, Follistatin/Osteonectin_EGF IPR002350, Kazal_dom IPR036058, Kazal_dom_sf IPR001999, Osteonectin_CS IPR037641, SPARC IPR019577, SPARC/Testican_Ca-bd-dom |
PANTHERi | PTHR13866:SF6, PTHR13866:SF6, 1 hit |
Pfami | View protein in Pfam PF09289, FOLN, 1 hit PF00050, Kazal_1, 1 hit PF10591, SPARC_Ca_bdg, 1 hit |
SMARTi | View protein in SMART SM00274, FOLN, 1 hit SM00280, KAZAL, 1 hit |
SUPFAMi | SSF100895, SSF100895, 1 hit SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS51465, KAZAL_2, 1 hit PS00612, OSTEONECTIN_1, 1 hit PS00613, OSTEONECTIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A1L1SSH9_MOUSE | |
Accessioni | A0A1L1SSH9Primary (citable) accession number: A0A1L1SSH9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 15, 2017 |
Last sequence update: | February 15, 2017 | |
Last modified: | February 10, 2021 | |
This is version 28 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |