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Protein

Transthyretin

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone, Thyroid hormoneUniRule annotation

Enzyme and pathway databases

ReactomeiR-GGA-2453902 The canonical retinoid cycle in rods (twilight vision)
R-GGA-3000171 Non-integrin membrane-ECM interactions
R-GGA-6798695 Neutrophil degranulation
R-GGA-975634 Retinoid metabolism and transport

Names & Taxonomyi

Protein namesi
Recommended name:
TransthyretinUniRule annotation
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20UniRule annotationAdd BLAST20
ChainiPRO_501183336221 – 149TransthyretinUniRule annotationAdd BLAST129

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 149TR_THYInterPro annotationAdd BLAST121

Sequence similaritiesi

Belongs to the transthyretin family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000005321

Family and domain databases

Gene3Di2.60.40.180, 1 hit
InterProiView protein in InterPro
IPR023418 Thyroxine_BS
IPR030178 Transthyretin
IPR000895 Transthyretin/HIU_hydrolase
IPR023416 Transthyretin/HIU_hydrolase_d
IPR036817 Transthyretin/HIU_hydrolase_sf
PANTHERiPTHR10395 PTHR10395, 1 hit
PTHR10395:SF12 PTHR10395:SF12, 1 hit
PfamiView protein in Pfam
PF00576 Transthyretin, 1 hit
PRINTSiPR00189 TRNSTHYRETIN
SMARTiView protein in SMART
SM00095 TR_THY, 1 hit
SUPFAMiSSF49472 SSF49472, 1 hit
PROSITEiView protein in PROSITE
PS00768 TRANSTHYRETIN_1, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1L1RWR0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFHSIFLVF LAGLAFFSEA APQVSGSSDS THPLVVKILD SVRGSPAPNV
60 70 80 90 100
PVKLYKAAAD GSWELLNSKE TNENGELQEL TTKEQFVTGI YKIELDTASY
110 120 130 140
WKKLGLNPFH QHADVVFTAN DAGYRHYSIA TVLSPFSYST TAVVSEPVE
Length:149
Mass (Da):16,269
Last modified:February 15, 2017 - v1
Checksum:i7CFB04DB9C8D902E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000228 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSGALT00000087557; ENSGALP00000063278; ENSGALG00000044733

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000228 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000087557; ENSGALP00000063278; ENSGALG00000044733

Phylogenomic databases

GeneTreeiENSGT00390000005321

Enzyme and pathway databases

ReactomeiR-GGA-2453902 The canonical retinoid cycle in rods (twilight vision)
R-GGA-3000171 Non-integrin membrane-ECM interactions
R-GGA-6798695 Neutrophil degranulation
R-GGA-975634 Retinoid metabolism and transport

Family and domain databases

Gene3Di2.60.40.180, 1 hit
InterProiView protein in InterPro
IPR023418 Thyroxine_BS
IPR030178 Transthyretin
IPR000895 Transthyretin/HIU_hydrolase
IPR023416 Transthyretin/HIU_hydrolase_d
IPR036817 Transthyretin/HIU_hydrolase_sf
PANTHERiPTHR10395 PTHR10395, 1 hit
PTHR10395:SF12 PTHR10395:SF12, 1 hit
PfamiView protein in Pfam
PF00576 Transthyretin, 1 hit
PRINTSiPR00189 TRNSTHYRETIN
SMARTiView protein in SMART
SM00095 TR_THY, 1 hit
SUPFAMiSSF49472 SSF49472, 1 hit
PROSITEiView protein in PROSITE
PS00768 TRANSTHYRETIN_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A1L1RWR0_CHICK
AccessioniPrimary (citable) accession number: A0A1L1RWR0
Entry historyiIntegrated into UniProtKB/TrEMBL: February 15, 2017
Last sequence update: February 15, 2017
Last modified: September 12, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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