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Protein

Glyceraldehyde-3-phosphate dehydrogenase

Gene

GAPDH

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
  2. Phosphoglycerate kinase (PGK), Phosphoglycerate kinase (PGK1), Phosphoglycerate kinase (PGK1), Phosphoglycerate kinase (PGK1)
  3. no protein annotated in this organism
  4. Alpha-enolase (ENO1), Beta-enolase (ENO3), Gamma-enolase (ENO2)
  5. Pyruvate kinase PKM (PKM), Pyruvate kinase (PKM), Pyruvate kinase (PKM)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38NAD; via carbonyl oxygenUniRule annotation1
Binding sitei80NADUniRule annotation1
Active sitei110NucleophileUniRule annotation1
Sitei137Activates thiol group during catalysisUniRule annotation1
Binding sitei140Glyceraldehyde 3-phosphateUniRule annotation1
Binding sitei192Glyceraldehyde 3-phosphateUniRule annotation1
Binding sitei274NADUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processGlycolysisUniRule annotation
LigandNADUniRule annotation, Nucleotide-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00184

Names & Taxonomyi

Protein namesi
Recommended name:
Glyceraldehyde-3-phosphate dehydrogenaseUniRule annotation (EC:1.2.1.12UniRule annotation)
Gene namesi
Name:GAPDHImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Pathology & Biotechi

Protein family/group databases

Allergomei12127 Gal d GAPDH

Expressioni

Gene expression databases

ExpressionAtlasiA0A1L1RUV2 baseline and differential

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

SMRiA0A1L1RUV2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 110Gp_dh_NInterPro annotationAdd BLAST110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni109 – 111Glyceraldehyde 3-phosphate bindingUniRule annotation3
Regioni169 – 170Glyceraldehyde 3-phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119172

Family and domain databases

InterProiView protein in InterPro
IPR020831 GlycerAld/Erythrose_P_DH
IPR020830 GlycerAld_3-P_DH_AS
IPR020829 GlycerAld_3-P_DH_cat
IPR020828 GlycerAld_3-P_DH_NAD(P)-bd
IPR006424 Glyceraldehyde-3-P_DH_1
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR10836 PTHR10836, 1 hit
PfamiView protein in Pfam
PF02800 Gp_dh_C, 1 hit
PF00044 Gp_dh_N, 1 hit
PIRSFiPIRSF000149 GAP_DH, 1 hit
PRINTSiPR00078 G3PDHDRGNASE
SMARTiView protein in SMART
SM00846 Gp_dh_N, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01534 GAPDH-I, 1 hit
PROSITEiView protein in PROSITE
PS00071 GAPDH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

A0A1L1RUV2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVYMFKYDST HGHFKGTVKA ENGKLVINGH AITIFQERDP SNIKWADAGA
60 70 80 90 100
EYVVESTGVF TTMEKAGAHL KGGAKRVIIS APSADAPMFV MGVNHEKYDK
110 120 130 140 150
SLKIVSNASC TTNCLAPLAK VIHDNFGIVE GLMTTVHAIT ATQKTVDGPS
160 170 180 190 200
GKLWRDGRGA AQNIIPASTG AAKAVGKVIP ELNGKLTGMA FRVPTPNVSV
210 220 230 240 250
VDLTCRLEKP AKYDDIKRVV KAAADGPLKG ILGYTEDQVV SCDFNGDSHS
260 270 280 290
STFDAGAGIA LNDHFVKLVS WYDNEFGYSN RVVDLMVHMA SKE
Length:293
Mass (Da):31,434
Last modified:February 15, 2017 - v1
Checksum:i16DF2A7C1C92275F
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P00356G3P_CHICK
Glyceraldehyde-3-phosphate dehydrog...
GAPDH GAPD
333Annotation score:
F1NH87F1NH87_CHICK
Glyceraldehyde-3-phosphate dehydrog...
GAPDH
333Annotation score:
A0A1D5PEE2A0A1D5PEE2_CHICK
Glyceraldehyde-3-phosphate dehydrog...
GAPDH
298Annotation score:
A0A1D5NXY1A0A1D5NXY1_CHICK
Glyceraldehyde-3-phosphate dehydrog...
GAPDH
264Annotation score:
A0A1L1RZ68A0A1L1RZ68_CHICK
Glyceraldehyde-3-phosphate dehydrog...
GAPDH
231Annotation score:
A0A1D5P6P0A0A1D5P6P0_CHICK
Glyceraldehyde-3-phosphate dehydrog...
GAPDH
112Annotation score:
A0A1L1RW15A0A1L1RW15_CHICK
Glyceraldehyde-3-phosphate dehydrog...
GAPDH
105Annotation score:
A0A1L1RVZ3A0A1L1RVZ3_CHICK
Glyceraldehyde-3-phosphate dehydrog...
GAPDH
69Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000389 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSGALT00000086833; ENSGALP00000062602; ENSGALG00000014442

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000389 Genomic DNA No translation available.

3D structure databases

SMRiA0A1L1RUV2
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei12127 Gal d GAPDH

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000086833; ENSGALP00000062602; ENSGALG00000014442

Phylogenomic databases

GeneTreeiENSGT00760000119172

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00184

Gene expression databases

ExpressionAtlasiA0A1L1RUV2 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR020831 GlycerAld/Erythrose_P_DH
IPR020830 GlycerAld_3-P_DH_AS
IPR020829 GlycerAld_3-P_DH_cat
IPR020828 GlycerAld_3-P_DH_NAD(P)-bd
IPR006424 Glyceraldehyde-3-P_DH_1
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR10836 PTHR10836, 1 hit
PfamiView protein in Pfam
PF02800 Gp_dh_C, 1 hit
PF00044 Gp_dh_N, 1 hit
PIRSFiPIRSF000149 GAP_DH, 1 hit
PRINTSiPR00078 G3PDHDRGNASE
SMARTiView protein in SMART
SM00846 Gp_dh_N, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01534 GAPDH-I, 1 hit
PROSITEiView protein in PROSITE
PS00071 GAPDH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A1L1RUV2_CHICK
AccessioniPrimary (citable) accession number: A0A1L1RUV2
Entry historyiIntegrated into UniProtKB/TrEMBL: February 15, 2017
Last sequence update: February 15, 2017
Last modified: October 10, 2018
This is version 17 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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