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Entry version 38 (07 Apr 2021)
Sequence version 1 (15 Feb 2017)
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Protein
Submitted name:

Hok/Gef family protein

Gene

pndA

Organism
Escherichia coli
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processToxin-antitoxin systemARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Hok/Gef family proteinImported
Submitted name:
Post-segregational killing protein PndAImported
Submitted name:
protein PndAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pndAImported
ORF Names:AM446_01300Imported, AWE53_027220Imported, BOH76_00625Imported, BON69_22440Imported, BON76_14220Imported, BON87_04650Imported, BON92_04855Imported, CR539_27375Imported, D6X76_20505Imported, D9G48_20620Imported, D9L99_25620Imported, DAH18_26175Imported, DU321_17795Imported, EA174_20790Imported, EA203_19965Imported, EF082_21645Imported, EHJ36_21010Imported, EPS94_22070Imported, EYY34_29210Imported, GE057_17885Imported, GQE33_18210Imported, HJI76_003919Imported, HJI79_003885Imported, HJI79_004998Imported, HJL93_003625Imported, HL601_20485Imported, HLY53_18705Imported, HLY53_26290Imported, HLZ85_19785Imported, HPE39_26680Imported, HV159_26345Imported, HX136_25705Imported, RCS56_PCDS0217Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniPlasmid RCS56_pImported
Plasmid p14EC033gImported
Plasmid p14ec033gImported
Plasmid pEC2-2Imported
Plasmid pRHBSTW-00321_4Imported
Plasmid pSCU-103-2Imported
Plasmid pec2-2Imported
Plasmid prhbstw-00321_4Imported
Plasmid pscu-103-2Imported
Plasmid rcs56_pImported
Plasmid unnamed3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coliImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri562 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000275882 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000297448 Componenti: Unassembled WGS sequence
  • UP000366120 Componenti: Unassembled WGS sequence
  • UP000262604 Componenti: Plasmid unnamed3
  • UP000477891 Componenti: Unassembled WGS sequence
  • UP000298444 Componenti: Unassembled WGS sequence
  • UP000298281 Componenti: Unassembled WGS sequence
  • UP000065249 Componenti: Unassembled WGS sequence
  • UP000449283 Componenti: Unassembled WGS sequence
  • UP000509796 Componenti: Plasmid pec2-2
  • UP000519688 Componenti: Unassembled WGS sequence
  • UP000528944 Componenti: Unassembled WGS sequence
  • UP000572087 Componenti: Unassembled WGS sequence
  • UP000234543 Componenti: Plasmid p14ec033g
  • UP000308023 Componenti: Plasmid rcs56_p
  • UP000523016 Componenti: Unassembled WGS sequence
  • UP000270175 Componenti: Unassembled WGS sequence
  • UP000297277 Componenti: Unassembled WGS sequence
  • UP000512409 Componenti: Plasmid prhbstw-00321_4
  • UP000396867 Componenti: Unassembled WGS sequence
  • UP000298067 Componenti: Unassembled WGS sequence
  • UP000413862 Componenti: Unassembled WGS sequence
  • UP000298215 Componenti: Unassembled WGS sequence
  • UP000272662 Componenti: Unassembled WGS sequence
  • UP000307175 Componenti: Unassembled WGS sequence
  • UP000387783 Componenti: Unassembled WGS sequence
  • UP000528699 Componenti: Unassembled WGS sequence
  • UP000290055 Componenti: Unassembled WGS sequence
  • UP000509690 Componenti: Plasmid pscu-103-2
  • UP000572436 Componenti: Unassembled WGS sequence
  • UP000560948 Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 24HelicalUniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Hok/Gef family.ARBA annotation
Belongs to the hok/gef family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000021, Hok/gef_toxin
IPR018084, Hok/gef_toxin_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01848, HOK_GEF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00281, HOKGEFTOXIC

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00556, HOK_GEF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1J8HK57-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPQRTFLMML IVVCVTILCF VWMVRDSLCG FRIEQGNTVL VATLAYEVKR
Length:50
Mass (Da):5,796
Last modified:February 15, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF4757270A3F21792
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP024154 Genomic DNA Translation: AUJ98863.1
CP032260 Genomic DNA Translation: AXZ83914.1
AAADNO010000026 Genomic DNA Translation: EAB0914928.1
AAADOH010000039 Genomic DNA Translation: EAB1136068.1
AAADQO010000023 Genomic DNA Translation: EAB1193851.1
DAAZUP010000026 Genomic DNA Translation: HAG9274305.1
DABDVF010000034 Genomic DNA Translation: HAI2486336.1
DABDVI010000017 Genomic DNA Translation: HAI2511361.1
DABDVI010000070 Genomic DNA Translation: HAI2512411.1
DABEAQ010000018 Genomic DNA Translation: HAI3217458.1
DABGZR010000029 Genomic DNA Translation: HAJ0997948.1
DABGHM010000030 Genomic DNA Translation: HAJ4893795.1
DABGHM010000181 Genomic DNA Translation: HAJ4895233.1
DABGMK010000029 Genomic DNA Translation: HAJ5740259.1
RDTN01000034 Genomic DNA Translation: KAA1851337.1
RDUF01000021 Genomic DNA Translation: KAA1946006.1
RNTA01000083 Genomic DNA Translation: MHN96539.1
RVWF01000149 Genomic DNA Translation: MMM60625.1
WSWW01000021 Genomic DNA Translation: MWE67906.1
CP054459 Genomic DNA Translation: QKQ01788.1
CP058573 Genomic DNA Translation: QLG60141.1
CP056607 Genomic DNA Translation: QLW14238.1
RRVG01000023 Genomic DNA Translation: RRL44501.1
LQSL02000005 Genomic DNA Translation: RRO68425.1
SCIX01000021 Genomic DNA Translation: RXB42762.1
LT985270 Genomic DNA Translation: SPE00739.1
MTWV01000005 Genomic DNA Translation: TEZ08564.1
MTXC01000059 Genomic DNA Translation: TEZ28221.1
MTXJ01000057 Genomic DNA Translation: TEZ67426.1
MTXU01000039 Genomic DNA Translation: TFA29277.1
MTXZ01000035 Genomic DNA Translation: TFA58315.1
QAEP01000035 Genomic DNA Translation: TGG57930.1
SZTZ01000258 Genomic DNA Translation: TLD59085.1

NCBI Reference Sequences

More...
RefSeqi
WP_001302699.1, NZ_WWEL01000051.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AUJ98863; AUJ98863; CR539_27375
AXZ83914; AXZ83914; AM446_01300
OKB81356; OKB81356; BMT53_27400
QBZ36008; QBZ36008; E5M00_27130

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
59685861

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP024154 Genomic DNA Translation: AUJ98863.1
CP032260 Genomic DNA Translation: AXZ83914.1
AAADNO010000026 Genomic DNA Translation: EAB0914928.1
AAADOH010000039 Genomic DNA Translation: EAB1136068.1
AAADQO010000023 Genomic DNA Translation: EAB1193851.1
DAAZUP010000026 Genomic DNA Translation: HAG9274305.1
DABDVF010000034 Genomic DNA Translation: HAI2486336.1
DABDVI010000017 Genomic DNA Translation: HAI2511361.1
DABDVI010000070 Genomic DNA Translation: HAI2512411.1
DABEAQ010000018 Genomic DNA Translation: HAI3217458.1
DABGZR010000029 Genomic DNA Translation: HAJ0997948.1
DABGHM010000030 Genomic DNA Translation: HAJ4893795.1
DABGHM010000181 Genomic DNA Translation: HAJ4895233.1
DABGMK010000029 Genomic DNA Translation: HAJ5740259.1
RDTN01000034 Genomic DNA Translation: KAA1851337.1
RDUF01000021 Genomic DNA Translation: KAA1946006.1
RNTA01000083 Genomic DNA Translation: MHN96539.1
RVWF01000149 Genomic DNA Translation: MMM60625.1
WSWW01000021 Genomic DNA Translation: MWE67906.1
CP054459 Genomic DNA Translation: QKQ01788.1
CP058573 Genomic DNA Translation: QLG60141.1
CP056607 Genomic DNA Translation: QLW14238.1
RRVG01000023 Genomic DNA Translation: RRL44501.1
LQSL02000005 Genomic DNA Translation: RRO68425.1
SCIX01000021 Genomic DNA Translation: RXB42762.1
LT985270 Genomic DNA Translation: SPE00739.1
MTWV01000005 Genomic DNA Translation: TEZ08564.1
MTXC01000059 Genomic DNA Translation: TEZ28221.1
MTXJ01000057 Genomic DNA Translation: TEZ67426.1
MTXU01000039 Genomic DNA Translation: TFA29277.1
MTXZ01000035 Genomic DNA Translation: TFA58315.1
QAEP01000035 Genomic DNA Translation: TGG57930.1
SZTZ01000258 Genomic DNA Translation: TLD59085.1
RefSeqiWP_001302699.1, NZ_WWEL01000051.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAUJ98863; AUJ98863; CR539_27375
AXZ83914; AXZ83914; AM446_01300
OKB81356; OKB81356; BMT53_27400
QBZ36008; QBZ36008; E5M00_27130
GeneIDi59685861

Family and domain databases

InterProiView protein in InterPro
IPR000021, Hok/gef_toxin
IPR018084, Hok/gef_toxin_CS
PfamiView protein in Pfam
PF01848, HOK_GEF, 1 hit
PRINTSiPR00281, HOKGEFTOXIC
PROSITEiView protein in PROSITE
PS00556, HOK_GEF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1J8HK57_ECOLX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1J8HK57
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 15, 2017
Last sequence update: February 15, 2017
Last modified: April 7, 2021
This is version 38 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

PlasmidImported
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