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Entry version 17 (05 Dec 2018)
Sequence version 1 (15 Feb 2017)
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Protein
Submitted name:

Endoribonuclease Dicer-like protein 1

Gene

LE_TR5729_c0_g1_i1_g.21099

Organism
Noccaea caerulescens (Alpine penny-cress) (Thlaspi caerulescens)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-bindingPROSITE-ProRule annotation
Biological processRNA-mediated gene silencingSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Endoribonuclease Dicer-like protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:LE_TR5729_c0_g1_i1_g.21099Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNoccaea caerulescens (Alpine penny-cress) (Thlaspi caerulescens)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri107243 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeColuteocarpeaeNoccaea

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini264 – 441Helicase ATP-bindingInterPro annotationAdd BLAST178
Domaini660 – 821Helicase C-terminalInterPro annotationAdd BLAST162
Domaini849 – 944Dicer dsRNA-binding foldInterPro annotationAdd BLAST96
Domaini1179 – 1319PAZInterPro annotationAdd BLAST141
Domaini1362 – 1516RNase IIIInterPro annotationAdd BLAST155
Domaini1557 – 1705RNase IIIInterPro annotationAdd BLAST149
Domaini1731 – 1794DRBMInterPro annotationAdd BLAST64
Domaini1829 – 1904DRBMInterPro annotationAdd BLAST76

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili230 – 250Sequence analysisAdd BLAST21

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family. Dicer subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00048 DSRM, 2 hits
cd00079 HELICc, 1 hit
cd00593 RIBOc, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1520.10, 1 hit
3.30.160.380, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014720 dsRBD_dom
IPR006935 Helicase/UvrB_N
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR003100 PAZ_dom
IPR036085 PAZ_dom_sf
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03368 Dicer_dimer, 1 hit
PF00271 Helicase_C, 1 hit
PF02170 PAZ, 1 hit
PF04851 ResIII, 1 hit
PF00636 Ribonuclease_3, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00358 DSRM, 2 hits
SM00490 HELICc, 1 hit
SM00949 PAZ, 1 hit
SM00535 RIBOc, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101690 SSF101690, 1 hit
SSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS50137 DS_RBD, 2 hits
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50821 PAZ, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1J3I2M9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVVEDERRED IKPSYWLDAC EDISCDLIDD LVSDFDPSSV AVVEPIDENG
60 70 80 90 100
VNNDFFGGID HILDSIKNGG GLPNGAHNKN GVSETNSRKS NGNSEVCEAP
110 120 130 140 150
QLIGGEIAVS VKGNGLHKCG GKRDQVSKEE EGEKSRKRAR VCSYQSERSN
160 170 180 190 200
LSANYRERDR FMNKKRTRNW DEAGHNNKRR DGYNYRREGR GYWERDKVGS
210 220 230 240 250
NELVYRSGTW EADHERDVKK ESGRNRECDV KKAEEEEEEK NKSKPEERKE
260 270 280 290 300
KVVEEQARRY QLDVLEQAKA KNTIAFLETG AGKTLIAILL IKSVHKDLMS
310 320 330 340 350
QNRKMLSVFL VPKVPLVYQQ AEVIRNQTCF QVGHYCGEMG QDFWDARRWQ
360 370 380 390 400
REFESKQVLV MTAQILLNIL RHSIIRMESI NLLILDECHH AVKKHPYSLV
410 420 430 440 450
MSEFYHTTPK DKRPAIFGMT ASPVNLKGVS SQVDCAIKIR NLETKLDSTV
460 470 480 490 500
CTIKDRKELE KHVPMPSEIV VEYDKAATMW SLHEKIKQMI AAVEDAAQAS
510 520 530 540 550
SRKSKWQFMG ARDAGAKDEL RQVYGVSERT ESDGAANLIH KLRAINYTLA
560 570 580 590 600
ELGQWCAYKV AQSFSTALQS DERVNFQVDV KFQESYLSEV VSLLQCELLE
610 620 630 640 650
GAAAEKAGAE VTKPENGNAN DDEIEEGELP DDHVVSGGEH VDEVIGAAVA
660 670 680 690 700
DGKVTPKVQS LIKLLLKYQH TADFRAIVFV ERVVAALVLP KVFAELPSLG
710 720 730 740 750
FIRCASMIGH NNSQEMKSSQ MQDTISKFRD GQVTLLVATS VAEEGLDIRQ
760 770 780 790 800
CNVVMRFDLA KTVLAYIQSR GRARKPGSDY ILMVERGNVS HAAFLRNARN
810 820 830 840 850
SEETLRKEAI ERTDLSHLKD TSRLISIDAV PGTVYKVETT GAMVSLNSAV
860 870 880 890 900
GLIHFYCSQL PGDRYAILRP EFCMEKHEKP GGHTEYSCRL QLPCNAPFEI
910 920 930 940 950
LEGPVCSSMR LAQQAVCLAG CKKLHEMGAF TDMLLPDKGS GQDAEKADQD
960 970 980 990 1000
EEGEPVPGTA RHREFYPEGV ADVLKGEWIL SGKEVCESTK LFHLYMYSVR
1010 1020 1030 1040 1050
CEDSGSSKDP FLTEVSEFAV LFGNELDAEV LSMSMDLYVA RAMITKASLA
1060 1070 1080 1090 1100
FRGSLDITES QLSSIKKFHV RLMSIVLDVD VEPSTTPWDP AKAYLFVPVT
1110 1120 1130 1140 1150
TDSKGINWEL VEKITETTVW DNPLQRARPD VYLGTNERTL GGDRREYGFG
1160 1170 1180 1190 1200
KLRDNKSHPT YGIRGAVASF DVVRASGLLP VRDAFEKEVV EGGDLSGGKL
1210 1220 1230 1240 1250
MMADGCMVAE NLLGKIVTAA HSGKRFYVDS ICYDMSAETS FPRKEGYLGP
1260 1270 1280 1290 1300
LEYNTYADYY KQKYGVDLSC KKQPLIKGRG VSYCKNLLSP RFEQSGESET
1310 1320 1330 1340 1350
VLDKTYYVFL PPELCVVHPL SGSLVRGAQK LPSIMRRVES MLLAVQLKNL
1360 1370 1380 1390 1400
ISFPIPTSKI LEALTAASCQ ETFCYERAEL LGDAYLKWVV SRFLFLKYPQ
1410 1420 1430 1440 1450
KHEGQLTRMR QQMVSNMVLY QYALVKGLQS YIQADRFAPS RWSAPGVPPV
1460 1470 1480 1490 1500
FDEDSKDGGS SFFDEDQKQG NSDVFEDGEM EDGELEGDLS SYRVLSSKTL
1510 1520 1530 1540 1550
ADVVEALIGV YYVEGGKIAA NHLMKWIGIH VEDDPEEIQG TVKPVNVSES
1560 1570 1580 1590 1600
VLKSIDFVGL EKALKYEFAE KGLLVEAITH ASRPSSGVSC YQRLEFVGDA
1610 1620 1630 1640 1650
VLDHLITRHL FFTYTSLPPG RLTDLRAAAV NNENFARVAV KHKLHLFLRH
1660 1670 1680 1690 1700
GSSALEKQIR DFVKEVLTES SKPGFNSFGL GDCKAPKVLG DIVESIAGAI
1710 1720 1730 1740 1750
FLDSGKDTTA AWKVFQPLLQ PMVTPETLPM HPVRELQERC QQQAEGLEYK
1760 1770 1780 1790 1800
ASRSGNTATV EVFIDGVQVG VAQNPQKKMA QKLAARNTLA ALKEKEAAEL
1810 1820 1830 1840 1850
KEKQANGNGE ENEGGGNENG NKKNGNQTFT RQTLNDICLR KNWPMPSYRC
1860 1870 1880 1890 1900
VKEGGPAHAK RFTFGVRVNT SDRGWTDECI GEPMPSVKKA KDSAALLLLE

LLNKTYS
Length:1,907
Mass (Da):212,852
Last modified:February 15, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC01A01BB6C0B527A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GEVL01002580 Transcribed RNA Translation: JAU74761.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GEVL01002580 Transcribed RNA Translation: JAU74761.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd00048 DSRM, 2 hits
cd00079 HELICc, 1 hit
cd00593 RIBOc, 2 hits
Gene3Di1.10.1520.10, 1 hit
3.30.160.380, 1 hit
InterProiView protein in InterPro
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014720 dsRBD_dom
IPR006935 Helicase/UvrB_N
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR003100 PAZ_dom
IPR036085 PAZ_dom_sf
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF03368 Dicer_dimer, 1 hit
PF00271 Helicase_C, 1 hit
PF02170 PAZ, 1 hit
PF04851 ResIII, 1 hit
PF00636 Ribonuclease_3, 2 hits
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00358 DSRM, 2 hits
SM00490 HELICc, 1 hit
SM00949 PAZ, 1 hit
SM00535 RIBOc, 2 hits
SUPFAMiSSF101690 SSF101690, 1 hit
SSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 2 hits
PROSITEiView protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS50137 DS_RBD, 2 hits
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50821 PAZ, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1J3I2M9_NOCCA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1J3I2M9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 15, 2017
Last sequence update: February 15, 2017
Last modified: December 5, 2018
This is version 17 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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