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Entry version 20 (10 Feb 2021)
Sequence version 1 (18 Jan 2017)
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Protein

Tyrosine--tRNA ligase

Gene
N/A
Organism
Macrostomum lignano
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).ARBA annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationARBA annotation, Ligase, RNA-binding, tRNA-bindingPROSITE-ProRule annotationARBA annotation
Biological processProtein biosynthesisUniRule annotationARBA annotation
LigandATP-bindingUniRule annotationARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tyrosine--tRNA ligaseUniRule annotation (EC:6.1.1.1UniRule annotation)
Alternative name(s):
Tyrosyl-tRNA synthetaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacrostomum lignanoImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri282301 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaSpiraliaLophotrochozoaPlatyhelminthesRhabditophoraMacrostomorphaMacrostomidaMacrostomidaeMacrostomum
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000095280 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1049 – 1152TRNA-bindingInterPro annotationAdd BLAST104

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1134 – 1154DisorderedSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00805, TyrRS_core, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.620, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002305, aa-tRNA-synth_Ic
IPR025714, Methyltranfer_dom
IPR012340, NA-bd_OB-fold
IPR014729, Rossmann-like_a/b/a_fold
IPR002547, tRNA-bd_dom
IPR002307, Tyr-tRNA-ligase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13679, Methyltransf_32, 1 hit
PF00579, tRNA-synt_1b, 2 hits
PF01588, tRNA_bind, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01040, TRNASYNTHTYR

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50249, SSF50249, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00234, tyrS, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50886, TRBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1I8IVH2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
PIDIFPNGQF NKLAAPVWRH TSLDTLARDC AACCLDCLRV AAQSFAELEQ
60 70 80 90 100
HQQASSSTDE ASASSTSAFI SHAMGIKKSH EVEQMSIICD RLARSRGVDL
110 120 130 140 150
LVDVGSGKGY LGACLYLAHG QRVLEIDAKP GNTAGAIKRR DNLEEKWRFL
160 170 180 190 200
QRRAEGNVKR LTPEEYRAEQ EVSASTATGD DEAASFCASI SAVVRDAQHL
210 220 230 240 250
ADIVAEKCGA KGGPFGLIGL HTCGQLACTL LQFYDQSPNC GLLVNVGCCY
260 270 280 290 300
NLLTEAFCTS PCEQLQRQQE AAQSIEPPAP GFPLSARLQA RRFCIGRNAR
310 320 330 340 350
ILASQSPERL ADSEDQRQMH RPIQHNMTQK QQLIIRNLQE VVGLDRLKAK
360 370 380 390 400
TAKHELSVYW GTATTGRPHV AYFVPMSKLA DYLLAGCHVT VLFADLHAYL
410 420 430 440 450
DNMKAPWSLL NKRTNYYETV IKGMLKSIGV PLDRLKFVRG TDFELGKEYT
460 470 480 490 500
RDVYRIAAEV TVHDAKKAGA EVVKQVASPL ISGLLYPCLQ ALDEQYLGVD
510 520 530 540 550
AQFGGVDQRK IFMLAEKYLV NLGYSKRIHL MNPMIPGLTG GKMSASEADS
560 570 580 590 600
KIDLLDSAES VSAKVAGAQC SPGAAEGNGV LSFLQYVVFP LLGGTDGLAI
610 620 630 640 650
GSSKKRYAEF QQVSEDFASG SLTAEDLKGC VADSLNRLLG PVRKEFEESS
660 670 680 690 700
ELQQLLVDAY PKDQPAKSSS GGDAGDVADR LPGIQLATID AKLIESLSRF
710 720 730 740 750
ATQFGSQDSV PVKSGSSPRL LWTIRPCGPM HLGHLVPLLG ALSMAKAGWR
760 770 780 790 800
VTLLVSEMQA FLDRKRAPID SLEVRGSTVK DVLSRLATGL LGDTAAAAVT
810 820 830 840 850
VTSGLEELSY NKDYVLDMYR LVSLVTVDEA MQAGSGVLSH GEHPPLSHLL
860 870 880 890 900
WPCLSALDAH HCRASVRLCG QDESSLSEFS SLALNCLGYP ATPSFAHAQL
910 920 930 940 950
PGLTGQSSMS LSDPDSAILA LESAASLKKK VKKMFCEPGN VDRCPPLDCL
960 970 980 990 1000
RLLLLPFKRL SGSEGDSIRV SRSAELGGDL VFASFDELKS AFVDKSLHPG
1010 1020 1030 1040 1050
DLKAHVESGL LEMQNRLREL IGPELTKKLD GAFAAPDKKS AGAAADELNP
1060 1070 1080 1090 1100
HRLDIRVGRI LDVSVHPDAD QLYVESVDLG EDRPRTVVSG LVKYLPADQL
1110 1120 1130 1140 1150
RNQLFLFLCN LKPAKMRGIE SSAMLLCASA TDGATVEPLN PPEGSNPGDR

VGFE
Length:1,154
Mass (Da):124,779
Last modified:January 18, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD8EEF0D6E1DD74B3
GO

Genome annotation databases

WormBase ParaSite

More...
WBParaSitei
maker-uti_cns_0017398-snap-gene-0.2-mRNA-1; maker-uti_cns_0017398-snap-gene-0.2-mRNA-1; maker-uti_cns_0017398-snap-gene-0.2

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

WBParaSiteimaker-uti_cns_0017398-snap-gene-0.2-mRNA-1; maker-uti_cns_0017398-snap-gene-0.2-mRNA-1; maker-uti_cns_0017398-snap-gene-0.2

Family and domain databases

CDDicd00805, TyrRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
InterProiView protein in InterPro
IPR002305, aa-tRNA-synth_Ic
IPR025714, Methyltranfer_dom
IPR012340, NA-bd_OB-fold
IPR014729, Rossmann-like_a/b/a_fold
IPR002547, tRNA-bd_dom
IPR002307, Tyr-tRNA-ligase
PfamiView protein in Pfam
PF13679, Methyltransf_32, 1 hit
PF00579, tRNA-synt_1b, 2 hits
PF01588, tRNA_bind, 1 hit
PRINTSiPR01040, TRNASYNTHTYR
SUPFAMiSSF50249, SSF50249, 1 hit
TIGRFAMsiTIGR00234, tyrS, 1 hit
PROSITEiView protein in PROSITE
PS50886, TRBD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1I8IVH2_9PLAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1I8IVH2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 18, 2017
Last sequence update: January 18, 2017
Last modified: February 10, 2021
This is version 20 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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