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UniProtKB - A0A1I8IIE8 (A0A1I8IIE8_9PLAT)

Entry version 20 (10 Feb 2021)
Sequence version 1 (18 Jan 2017)
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Protein

RRM domain-containing protein

Gene
N/A
Organism
Macrostomum lignano
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, RNA-bindingPROSITE-ProRule annotation, Sodium channelUniRule annotationARBA annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RRM domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacrostomum lignanoImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri282301 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Spiralia › Lophotrochozoa › Platyhelminthes › Rhabditophora › Macrostomorpha › Macrostomida › Macrostomidae › Macrostomum
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000095280 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1146 – 1186RRMInterPro annotationAdd BLAST41

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR031941, DUF4773
IPR001873, ENaC
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom

The PANTHER Classification System

More...PANTHERi		PTHR11690, PTHR11690, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00858, ASC, 1 hit
PF15998, DUF4773, 1 hit
PF00076, RRM_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01078, AMINACHANNEL

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928, SSF54928, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50102, RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1I8IIE8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEIQARRSR ENRTTPDSIV GGRRKLIRQF CDSTSAHGFH KIVENGEGAL 
        60         70         80         90        100
HRAAWLFIIL AAGAGFTAHL FALFSRYLER PVNTETSVYG TKFVFPDVTI 
       110        120        130        140        150
CATSHFSRLR YQQNPPVPSL NISTHELLHH IRTFWDPGEN ADTNISINAD 
       160        170        180        190        200
VMHSIKSYLR ELNITKQRQE MILHCDFAGD SCSYRNFSLY VDPNYFSCYT 
       210        220        230        240        250
FAPTERHLIV GGERDGGLNV IMYVGDVKNF ITGEESLSYS EGFRAVIHEP 
       260        270        280        290        300
GTRPELLEGF YVQRDTSTYV QLGYTEEVVL KNCSLDANFQ TVKFVDRYNR 
       310        320        330        340        350
ITEYRYTIRD CLVNTYQTYL RTNCSCVSEA LPLPANLNSN LSVPFCHSIS 
       360        370        380        390        400
RESLMESIDQ QAATEAEAAI ERNQAAEHRR ACHDSVVSEI HKKTSGLAPD 
       410        420        430        440        450
VCPLRCKNVR YEMRFTQNRW PSACNETSQA LAEAVERTIA LAAEQGDDLT 
       460        470        480        490        500
TLVEIQRRMS DEHREPAFRE SFAKLTIYTH STMGSVMRES WAYPDRNLAS 
       510        520        530        540        550
DIGGILGLWL GVSIISTFEF LELFARLLFW HFPLTKANRS SSRSGGGGGT 
       560        570        580        590        600
GGSNSRCIET QLAVLAFARL ARSLLLLLLL GRGARASSFD TFGQVVHHHL 
       610        620        630        640        650
VLGASSSGVN AYRWLFCEGR HRMIITNSMT ENSRCQNASS IQSSRQAAMQ 
       660        670        680        690        700
SANLCLLTVQ VMNTTEQTTQ NTKVLVKCLY RDNFTRLRRT RRLRIVCTSE 
       710        720        730        740        750
LKIHQQMMAS VTARGMLRLF IVQRRSPSIF INAGVLLGAR RLAEPPANPE 
       760        770        780        790        800
ASSIGASWHS CRSIALTNNV HKNFGILVQT LGECHVLILA SQIGLFDALL 
       810        820        830        840        850
RADQERQLDE LSLWLKYQKI LLSVNFQNNK EMPRLSFRCC KHFFCCKQNF 
       860        870        880        890        900
LLCILLCAMA LIMLHYAWIG ASDGSSINSD LDAANSNGHT DSSRLGYAKA 
       910        920        930        940        950
FYNKLRGNLK GNASSLIGAG QVLIGPASRH FAFNYNVSQA RLAELLADTM 
       960        970        980        990       1000
QMMELQKTAH KTLAYMVSIQ PDFDANAGSC RCGSISELCH CCARVALRPI 
      1010       1020       1030       1040       1050
RLEQTVCIDF RYEVHRKSLR TRIVLANSGT VVVEQLLGAA RPPVLCAGSA 
      1060       1070       1080       1090       1100
LELCASFRNT SYTVMLHSEH KTRLRGCLDL LVNLVNSTVA AYPMGCFEAH 
      1110       1120       1130       1140       1150
GRSGAAAAAA VTCVAKARIW DSLWESMSRG CHNQELVPAQ PPARLMKLFV 
      1160       1170       1180 
GQIPRSMDAE SLRPMFEKFG QILDLTVLRD RLTGVH
Length:1,186
Mass (Da):132,604
Last modified:January 18, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i888FF7816C1F2E00
GO

Genome annotation databases

WormBase ParaSite

More...WBParaSitei		maker-uti_cns_0012763-snap-gene-0.2-mRNA-1; maker-uti_cns_0012763-snap-gene-0.2-mRNA-1; maker-uti_cns_0012763-snap-gene-0.2

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

WBParaSiteimaker-uti_cns_0012763-snap-gene-0.2-mRNA-1; maker-uti_cns_0012763-snap-gene-0.2-mRNA-1; maker-uti_cns_0012763-snap-gene-0.2

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR031941, DUF4773
IPR001873, ENaC
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
PANTHERiPTHR11690, PTHR11690, 1 hit
PfamiView protein in Pfam
PF00858, ASC, 1 hit
PF15998, DUF4773, 1 hit
PF00076, RRM_1, 1 hit
PRINTSiPR01078, AMINACHANNEL
SUPFAMiSSF54928, SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102, RRM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1I8IIE8_9PLAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1I8IIE8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 18, 2017
Last sequence update: January 18, 2017
Last modified: February 10, 2021
This is version 20 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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