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UniProtKB - A0A1I8I513 (A0A1I8I513_9PLAT)

Entry version 17 (10 Feb 2021)
Sequence version 1 (18 Jan 2017)
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Protein
Submitted name:

Uncharacterized protein

Gene
N/A
Organism
Macrostomum lignano
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi149 – 160PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradationARBA annotation
LigandCalciumPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacrostomum lignanoImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri282301 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Spiralia › Lophotrochozoa › Platyhelminthes › Rhabditophora › Macrostomorpha › Macrostomida › Macrostomidae › Macrostomum
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000095280 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1056 – 1081HelicalSequence analysisAdd BLAST26
Transmembranei1102 – 1119HelicalSequence analysisAdd BLAST18
Transmembranei1139 – 1156HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell projectionARBA annotation, Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini108 – 123EF-handInterPro annotationAdd BLAST16
Domaini136 – 171EF-handInterPro annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni307 – 337DisorderedSequence analysisAdd BLAST31
Regioni560 – 641DisorderedSequence analysisAdd BLAST82
Regioni667 – 904DisorderedSequence analysisAdd BLAST238
Regioni942 – 996DisorderedSequence analysisAdd BLAST55
Regioni1250 – 1288DisorderedSequence analysisAdd BLAST39

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1009 – 1036Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi583 – 605PolarSequence analysisAdd BLAST23
Compositional biasi674 – 688PolarSequence analysisAdd BLAST15
Compositional biasi756 – 790PolyampholyteSequence analysisAdd BLAST35
Compositional biasi844 – 858PolarSequence analysisAdd BLAST15
Compositional biasi884 – 901PolarSequence analysisAdd BLAST18
Compositional biasi1250 – 1269PolarSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM237 family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR039800, MICU1/2/3
IPR029409, TMEM237

The PANTHER Classification System

More...PANTHERi		PTHR12294, PTHR12294, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15383, TMEM237, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1I8I513-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
SVEKDEFDIL NTMVSECQAE QQQDTTLMRH FFGQSGKDSL DYNRFVEFMS 
        60         70         80         90        100
NLQYEVLELE FLEFSKGLPS IPESEFARVL LRYTNLSPST QAVWVDQVRD 
       110        120        130        140        150
KLVREEGIGF EDFRQFFQFL NSLADFSMAL QMYALAGHRV VSTVFLLLDK 
       160        170        180        190        200
DGDGSLSSDE LLAILKGRLK RLIHLLPQHV LLDALPVPLP RGVLAIAAVA 
       210        220        230        240        250
VPAPQPGGLA LAEQAEELAV GQRPVAVDVE HGEQDRQQLG RHTAASGGHH 
       260        270        280        290        300
RPLEVLLADG LAGDLKHAQG EEQVAGVQQE LEELLVLLSC YTFRLPRPVL 
       310        320        330        340        350
QQRQAEATLG GRQAGPAKNR APEVEWRHDG RGGGAQAGPE LGQQHLALQV 
       360        370        380        390        400
VGEFGELGSR DGVAGVGAEK VHKQAGAGVV VHQQLGARVS GGAVRRDDAV 
       410        420        430        440        450
QPAELVGVQG AVAIAIKGAE GDLEAGAGLG EHIEQQQELR VGDEAVAAEV 
       460        470        480        490        500
AEQVVAGAAL AGRGAQHRPV FGLGQHVTST ANSATSLGFG RRFIVAAGVE 
       510        520        530        540        550
SDGLKEVERA EVGGAIVLQR GELQKAALAP VQAAPAAGPG CRGLRGRQLR 
       560        570        580        590        600
FGHGNGGGSS GSLFELSEGQ RGSCGGGGSC GQEETLPSAS RSRRSRASIK 
       610        620        630        640        650
SSTTEAEHPA LLLMAQTMGR RRCRRGSSEA AGAGKAASAN KLCRQPKSHV 
       660        670        680        690        700
RCLLSCRLMA DRARRESMRR AGGQLELITT QQGRSAKTPI NIEEGMKKSV 
       710        720        730        740        750
EKRRRRKRTG PGGYASLSTR EVKKRRGQKQ EETVQCSAVQ CTEEAKRRKR 
       760        770        780        790        800
KRSRVSISKA SESPKKHHGG PEPAGGHGRN WRRRWAAAPT KEAAEPRWAS 
       810        820        830        840        850
APGDAGTALD AAQRALTARR GQGGKRSDSR PARRTRRPRQ TMGRRQSARS 
       860        870        880        890        900
SSCCQRRPLV TTGLRLERHQ AEQRLRGRVA RSGGSQHRRQ QQQQRRQQGQ 
       910        920        930        940        950
TLPKLRRLAA AQKAVRRNPQ LQRRHHGLGI STSRACRWPR RWRQSAPTWS 
       960        970        980        990       1000
PGRVPAAAST SAPTSDADGP AGDVKADDED EAAIGGGGGG RAGESNMSDT 
      1010       1020       1030       1040       1050
IFWQTQDAKT FKAEKLDKYQ QRLEQERKER EQYLEGVVEE DTSNRTLKCA 
      1060       1070       1080       1090       1100
IGFTKVYNYL GTVLLGLMPG FALLHTVYVW TLSSNYLSFL ADYSRLGSPM 
      1110       1120       1130       1140       1150
PILYYVVLTL ILLSVLDRYD TGKLDRGSCL ECASFRHGGM VVLLYIPAYV 
      1160       1170       1180       1190       1200
VSNAMYPTDQ WMRGYSLNAT AYAGIANGDS LVQSWRIMDT VRAACLALGW 
      1210       1220       1230       1240       1250
LVVAFNPQFN RLADNLETSW TTSSPHSPAL AGPAAAAAED EAAAVSLFGD 
      1260       1270       1280       1290       1300
SSGDSSGSAG RSGRSRGIGS SGGSGGGGGS GTQHHAAPVM AAASRAAVAV 
      1310       1320       1330       1340 
AAADRGGEVL LRIWERAPDK MRLRDGSQQK KRLELLSCLL EEAKKFNAE
Length:1,349
Mass (Da):145,427
Last modified:January 18, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9420EE72A7536E5C
GO

Genome annotation databases

WormBase ParaSite

More...WBParaSitei		maker-uti_cns_0009972-snap-gene-0.3-mRNA-1; maker-uti_cns_0009972-snap-gene-0.3-mRNA-1; maker-uti_cns_0009972-snap-gene-0.3

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

WBParaSiteimaker-uti_cns_0009972-snap-gene-0.3-mRNA-1; maker-uti_cns_0009972-snap-gene-0.3-mRNA-1; maker-uti_cns_0009972-snap-gene-0.3

Family and domain databases

InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR039800, MICU1/2/3
IPR029409, TMEM237
PANTHERiPTHR12294, PTHR12294, 1 hit
PfamiView protein in Pfam
PF15383, TMEM237, 1 hit
SUPFAMiSSF47473, SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1I8I513_9PLAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1I8I513
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 18, 2017
Last sequence update: January 18, 2017
Last modified: February 10, 2021
This is version 17 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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