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UniProtKB - A0A1I8GZL1 (A0A1I8GZL1_9PLAT)

Entry version 12 (10 Feb 2021)
Sequence version 1 (18 Jan 2017)
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Protein

G_PROTEIN_RECEP_F1_2 domain-containing protein

Gene
N/A
Organism
Macrostomum lignano
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G_PROTEIN_RECEP_F1_2 domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacrostomum lignanoImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri282301 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Spiralia › Lophotrochozoa › Platyhelminthes › Rhabditophora › Macrostomorpha › Macrostomida › Macrostomidae › Macrostomum
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000095280 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1366 – 1387HelicalSequence analysisAdd BLAST22
Transmembranei1399 – 1425HelicalSequence analysisAdd BLAST27
Transmembranei1437 – 1459HelicalSequence analysisAdd BLAST23
Transmembranei1480 – 1498HelicalSequence analysisAdd BLAST19
Transmembranei1529 – 1553HelicalSequence analysisAdd BLAST25
Transmembranei1574 – 1594HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1375 – 1644G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST270

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 24DisorderedSequence analysisAdd BLAST24
Regioni133 – 172DisorderedSequence analysisAdd BLAST40
Regioni185 – 209DisorderedSequence analysisAdd BLAST25
Regioni381 – 403DisorderedSequence analysisAdd BLAST23
Regioni466 – 493DisorderedSequence analysisAdd BLAST28
Regioni520 – 540DisorderedSequence analysisAdd BLAST21
Regioni625 – 676DisorderedSequence analysisAdd BLAST52
Regioni692 – 742DisorderedSequence analysisAdd BLAST51
Regioni1012 – 1067DisorderedSequence analysisAdd BLAST56
Regioni2221 – 2254DisorderedSequence analysisAdd BLAST34
Regioni2808 – 2839DisorderedSequence analysisAdd BLAST32
Regioni3028 – 3047DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi469 – 493PolarSequence analysisAdd BLAST25
Compositional biasi650 – 676PolarSequence analysisAdd BLAST27
Compositional biasi1042 – 1067BasicSequence analysisAdd BLAST26
Compositional biasi2818 – 2836PolyampholyteSequence analysisAdd BLAST19

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017452, GPCR_Rhodpsn_7TM

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1I8GZL1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKANGLRNHG KVKSNLGHVR PHSERFEEQA SFNASPVGGA DLRVTLESNG 
        60         70         80         90        100
LTPSLRGFGD RFHQAASISS GLSVSDSGLC AIAGSVQRQP RIDAAFSNGQ 
       110        120        130        140        150
SDNVARRIKV HGARTVPWGA NHQVGIAAAI ERPRQRRCKA PKPAGRPSRQ 
       160        170        180        190        200
SSSRWLARRD RTGQQMPGQL GLRGDASRCV ISCGHPVQPH NSTPDGAGSP 
       210        220        230        240        250
PPAGFNIVGD EAFTEGRRPK SGQVRHAGRA FDKIEASHSA SGRPHQPGRE 
       260        270        280        290        300
LPLQLSGVFR TQVGQEAVKL HILCGIPLFQ VIGSKPSDIA VTPHQQRFGC 
       310        320        330        340        350
SIQRRRGQIG AVENPAEAQQ QIWDAECTPM PATLPAIRTR ALGSHTSTLS 
       360        370        380        390        400
SLAGRPLPKV EATDKPKLPI FHACSRRPEA RFSPQLPASR LQAKKPPRPF 
       410        420        430        440        450
EDVEKELSEL SASRMPQTTA PSCKRLVRSA LPVSLDPTVS SDVITETNVA 
       460        470        480        490        500
SVPDCAEREA ALWQSFLRAP PPANSSSSST MRRSRSPGPT ASHVTRVLGS 
       510        520        530        540        550
EAGESVWTVA NLEQLIQRGP TGSMSCSRVS NSSTGSSGSV QHLQIGLTGC 
       560        570        580        590        600
YRIEAAGARG GSKLSKGTVG GHGATAAANF SLTAGIRLDI AVGQAGSNES 
       610        620        630        640        650
VNGAAPGGGG GSFVWTSDGS ETRLLLAAGG GGGGATGGKG LPGEAGRNGS 
       660        670        680        690        700
DTIGTHSRLS GLGGTNGAPG SNTPRDAASN CNHGGCGAGW LGKAVNPRRG 
       710        720        730        740        750
NTDGERGGSV ADGWVGGSGG DGGGGNGGFG GGGGGGGSAS GTRGAPGAGG 
       760        770        780        790        800
GFSGGGAGLG FGHAGGGGGS ACIGGSGCVT VTGGNADNEQ GRVAVRLLDA 
       810        820        830        840        850
SSSIPKPGAA TLVHERTVQR RRFDASVAAA AASHRLPERQ HPLNRIVLVL 
       860        870        880        890        900
DVNAASLPDN VVFHSCGHHN TVSLGISTGA LHLLAAPGFK AEFFAAFFVT 
       910        920        930        940        950
IQNGVDCGAC HPNLSEVLSN GMVALSGVLS FVLYDQASAL LFTFKSRGLL 
       960        970        980        990       1000
VAMCRWGCSL VDTTYMCKWC GTRFCKECLL GDFYGRMKEP GQCRVCNQKR 
      1010       1020       1030       1040       1050
CQGKRVEFVT KPRDPADEAA SGRGSGRRGV GGASAKSSKS AKSAGSKKKK 
      1060       1070       1080       1090       1100
SSSAGGGKKK KSAGKKKRGK KLLIAVLALP LVAVSGGSQL PQSTHAMLSH 
      1110       1120       1130       1140       1150
LPERNMTRPE VIHLLNELKK YVKVMEQDEY RRFSELVFTL RSKLFETFNQ 
      1160       1170       1180       1190       1200
AFEGIKMSDY NVLCHFRVYP SLIFGSNYPT VQELTITLMD FVIESLRGGD 
      1210       1220       1230       1240       1250
TKPFLFVYVR LYLQLGQPYV TYSNLLRHSG DRTAETLYTF AKSCLPEVDV 
      1260       1270       1280       1290       1300
PPDCRKTLLM QLSDPRLLLR PRCELEDLAR GNPNSQSSSQ HHDSMTSVLQ 
      1310       1320       1330       1340       1350
YKLLSHVARS GNFDYYNTTH RIIEFIELII FGHFDALRIP NRMWINPTFK 
      1360       1370       1380       1390       1400
ASLPGKLSAV AQLIRYGYPI LLLIGTVSNL IALLFSLVNL SESISCMYFL 
      1410       1420       1430       1440       1450
ALSVLDLLCL WCNLLPILLS LYFDIFAQEA SQLTCKLIPF FGIFTAGSVA 
      1460       1470       1480       1490       1500
WLVVALTYTK LATLVRPFWH SLYSRRVHRL LILGLIVLVA AMCSPLLFTR 
      1510       1520       1530       1540       1550
YRLVVLDSDF FIQCWRYEST VFSYGLEKMW LALVFPVIPL LLVLAGNCAL 
      1560       1570       1580       1590       1600
IALRTRHLRQ LSRGSGYCVD DKSFGSLVGV SCVFLAFTAP NTVVQMIEAF 
      1610       1620       1630       1640       1650
RSQNINYYDV TDELNNGNGT LFNYWIHVTH FVMLLHNAVN IFTYGMSAPY 
      1660       1670       1680       1690       1700
LRKSFRLRLA RLVGGPRLLL AATSSSTSRS SSLRREDTYG SALSVKSGTS 
      1710       1720       1730       1740       1750
SLSAPCSNSY PVIWMANAEC ANQSFSGLCV QMPPAAAEAV ENSPLGLLSR 
      1760       1770       1780       1790       1800
LRAGGLVFAE NPGQLAAQQV AVDAILVGVG QQLLRLPGSG GGWDAFTTTE 
      1810       1820       1830       1840       1850
ICGCKQLSGA QNLFGIGHVR EQVLSSQVVP ADVTDEADNL AWKRLRLDIP 
      1860       1870       1880       1890       1900
YQLIPMGYPQ HIYPYPRTNP NPPTRQLSET GRNALYIVVV FVRIFASRRG 
      1910       1920       1930       1940       1950
RATAIGQPDG RSKVVRFEPG HRAGESAGNG EWQAETGGHQ IRLWYEEEVL 
      1960       1970       1980       1990       2000
PASQHLQGGE AVLTTTRMSS GLNTGLGCSS AHRRIASAMC LSFNDNDNLI 
      2010       2020       2030       2040       2050
DCCESTSILD VVGVSRIKAG QVSPPKASLP LKCQRTGTRP VLRKDTPVSK 
      2060       2070       2080       2090       2100
LISYSFVAPR AVNYYQVTSG SISLNSSVTS QLLADTTEDS DGSCARPGHG 
      2110       2120       2130       2140       2150
VRVWKADDFN EKRRKGTVVK YMYFYKSGSG RTDTVQYLTV AEAGCYRIDA 
      2160       2170       2180       2190       2200
FGARGGFDFD ATKQPGRGAS VSGSFSLTAD TQLAIVVAQA GGNSAAEQAG 
      2210       2220       2230       2240       2250
SGGGGGSFVY RSGDSQPLLA AGIAGSSDTK GADTNYPAST DDIGAGRTDG 
      2260       2270       2280       2290       2300
GPGKVPTTRY TVQFRFFITD CYTYGKGGPG AGDGGFGGGG GGANGGNFGR 
      2310       2320       2330       2340       2350
DFGASGGGGG YSIWQRLRHR CWRISSTRAA VSSGVENSVS TFEQGTLIAA 
      2360       2370       2380       2390       2400
AFASVSNACP CKLTDAVRLS SRADQCSGVS LSQLIVASNA ACSSRQHRGR 
      2410       2420       2430       2440       2450
IASQSAVGCN RRSASVLHPL QRAGHGQQVG VEFLSLLGGG AGSVPPVLQT 
      2460       2470       2480       2490       2500
AEVAAVELDA NADLLAICRR HHNRHCHCRC CRRDRCRRRR RNDLECQRNC 
      2510       2520       2530       2540       2550
GSDCGYDFCY ADEVASYRGV GRYSRRHFPP AWRRCQMIDA STKTIWIFFS 
      2560       2570       2580       2590       2600
TAAAAAAETR AARRPDAANR RRVTRTSGCY SSHNAADCYG YGYGCDCGCD 
      2610       2620       2630       2640       2650
CGCDFGCDWD CQLTPGWSCS RCRGLRCTPG RAVSTGSERA ALGQRLQSQH 
      2660       2670       2680       2690       2700
DVPSEAVHPA AGAAVGTRAA KPGPADVQIF AVGHLALAPA FAIVDAELYG 
      2710       2720       2730       2740       2750
VYGEAAELEM VLILDGTASR QRGLLHTSLG TKLDGQIFGS LSNSQSKSGN 
      2760       2770       2780       2790       2800
KIIPVQTASQ ETWANYAHQP DCDLVYNQPW CIRRQASCDR CATVYTRHPD 
      2810       2820       2830       2840       2850
SPAESNCTWG TGLARKQTPA ERRSDWSSEG SKVPDQKRVA ARAAAGNDLL 
      2860       2870       2880       2890       2900
IRSKPITSAA KTSAASPTVT VVVVIAAATA AATAAAESIG PSASRVLSKS 
      2910       2920       2930       2940       2950
VGAAAAAAAA ATASTAGAGR GNGTGSSRRY VGVTRTSAAI RPAFHSTSDS 
      2960       2970       2980       2990       3000
FGHVAGQVDR LLGVRAEKIR IDSLQLGANL AQGDSAKFLT RILAQRSNSI 
      3010       3020       3030       3040       3050
LPAGSLSNSC MSKAHRFTRL AGMSESVAHG FGQDSGRPPP KNASNSSHWL 
      3060       3070       3080       3090       3100
QWANSSLTSP AGTLQSGDRN RRTGTLPRAS AALSLSACIS DSQASTGLTR 
      3110       3120       3130       3140 
PLGMGKFAGL WLGFFGRLAR QSLRISSSVL LTVPGGGLYR IQKPRS
Length:3,146
Mass (Da):333,637
Last modified:January 18, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1A9112AB4E0A9799
GO

Genome annotation databases

WormBase ParaSite

More...WBParaSitei		maker-uti_cns_0003792-snap-gene-0.2-mRNA-1; maker-uti_cns_0003792-snap-gene-0.2-mRNA-1; maker-uti_cns_0003792-snap-gene-0.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

WBParaSiteimaker-uti_cns_0003792-snap-gene-0.2-mRNA-1; maker-uti_cns_0003792-snap-gene-0.2-mRNA-1; maker-uti_cns_0003792-snap-gene-0.2

Family and domain databases

InterProiView protein in InterPro
IPR017452, GPCR_Rhodpsn_7TM
PROSITEiView protein in PROSITE
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1I8GZL1_9PLAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1I8GZL1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 18, 2017
Last sequence update: January 18, 2017
Last modified: February 10, 2021
This is version 12 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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