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UniProtKB - A0A1I8GZE5 (A0A1I8GZE5_9PLAT)

Entry version 17 (10 Feb 2021)
Sequence version 1 (18 Jan 2017)
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Protein
Submitted name:

Uncharacterized protein

Gene
N/A
Organism
Macrostomum lignano
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi421 – 432PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi596 – 607PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradationARBA annotation
LigandCalciumPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacrostomum lignanoImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri282301 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Spiralia › Lophotrochozoa › Platyhelminthes › Rhabditophora › Macrostomorpha › Macrostomida › Macrostomidae › Macrostomum
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000095280 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Transmembranei150 – 169HelicalSequence analysisAdd BLAST20
Transmembranei262 – 280HelicalSequence analysisAdd BLAST19
Transmembranei1468 – 1493HelicalSequence analysisAdd BLAST26
Transmembranei1514 – 1531HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell projectionARBA annotation, Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini408 – 443EF-handInterPro annotationAdd BLAST36
Domaini534 – 549EF-handInterPro annotationAdd BLAST16
Domaini583 – 618EF-handInterPro annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni211 – 240DisorderedSequence analysisAdd BLAST30
Regioni754 – 784DisorderedSequence analysisAdd BLAST31
Regioni1007 – 1089DisorderedSequence analysisAdd BLAST83
Regioni1131 – 1340DisorderedSequence analysisAdd BLAST210
Regioni1643 – 1684DisorderedSequence analysisAdd BLAST42
Regioni1696 – 1735DisorderedSequence analysisAdd BLAST40
Regioni1768 – 1794DisorderedSequence analysisAdd BLAST27
Regioni1851 – 1872DisorderedSequence analysisAdd BLAST22
Regioni1888 – 1920DisorderedSequence analysisAdd BLAST33
Regioni1995 – 2074DisorderedSequence analysisAdd BLAST80
Regioni2177 – 2208DisorderedSequence analysisAdd BLAST32

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1421 – 1448Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi226 – 240PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1030 – 1052PolarSequence analysisAdd BLAST23
Compositional biasi1131 – 1172PolyampholyteSequence analysisAdd BLAST42
Compositional biasi1697 – 1717PolarSequence analysisAdd BLAST21
Compositional biasi1858 – 1872Pro-richSequence analysisAdd BLAST15
Compositional biasi1888 – 1907PolyampholyteSequence analysisAdd BLAST20
Compositional biasi1996 – 2011PolarSequence analysisAdd BLAST16
Compositional biasi2028 – 2055PolyampholyteSequence analysisAdd BLAST28
Compositional biasi2184 – 2201BasicSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM237 family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR039800, MICU1/2/3
IPR029409, TMEM237

The PANTHER Classification System

More...PANTHERi		PTHR12294, PTHR12294, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15383, TMEM237, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1I8GZE5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMSSRRPQSM TRGRASLLLS SHSLASSSTF WLMSKKNALD SCLSCERCRH 
        60         70         80         90        100
SLVSSWICSS EYLAMAFRSS FFCDSRLARK DLRRSSICAV AFGNRSLYTL 
       110        120        130        140        150
FISNRSCGPR RTRVRVRAAV LLLLLLLLLL LLLLLLYTMG HSGLRLAGRW 
       160        170        180        190        200
RVMVMVVVMV VVVRVEVLLG RALAGDVAAL RCVGAVARGG QRGQGPAADV 
       210        220        230        240        250
RLATLGAQAP AADAGSVDDV DGRDDEADDA GRAEQDRAIS NARKQAVKTV 
       260        270        280        290        300
SMQGMLRTLL RPAAYAATAV AAVAVAATSV PERRQSRQEH PIQNGLMRLR 
       310        320        330        340        350
ELRVAAPMLA AATTKPAHGH LEERFLEFAS VEFNDTAYMT PEDFLESVTQ 
       360        370        380        390        400
DRPRFRRGRK LLSDADVEQM LRKAPSHRRA SKKLMRSLGH DGIVSYSEYL 
       410        420        430        440        450
FLLCTLANAE SGFSIAFNMI DRSRNQSVEK DEFDILNTMV SECQAEQQQD 
       460        470        480        490        500
TTLMRHFFGQ SGKDSLDYNR FVEFMSNLQY EVLELEFLEF SKGLPSIPES 
       510        520        530        540        550
EFARVLLRYT NLSPSTQAVW VDQVRDKLVR EEGIGFEDFR QFFQFLNSLA 
       560        570        580        590        600
DFSMALQMYA LAGHPVTQDE FQRAVKACVG YTLSPRVVST VFLLLDKDGD 
       610        620        630        640        650
GSLSSDELLA ILKGRLKRLI HLLPQHVLLD ALPVPLPRGV LAIAAVAVPA 
       660        670        680        690        700
PQPGGLALAE QAEELAVGQR PVAVDVEHGE QDRQQLGRHT AASGGHHRPL 
       710        720        730        740        750
EVLLADGLAG DLKHAQGEEQ VAGVQQELEE LLVLLSCYTF RLPRPVLQQR 
       760        770        780        790        800
QAEATLGGRQ AGPAKNRAPE VEWRHDGRGG GAQAGPELGQ QHLALQVVGE 
       810        820        830        840        850
FGELGSRDGV AGVGAEKVHK QAGAGVVVHQ QLGARVSGGA VRRDDAVQPA 
       860        870        880        890        900
ELVGVQGAVA IAIKGAEGDL EAGAGLGEHI EQQQELRVGD EAVAAEVAEQ 
       910        920        930        940        950
VVAGAALAGR GAQHRPVFGL GQHVTSTANS ATSLGFGRRF IVAAGVESDG 
       960        970        980        990       1000
LKEVERAEVG GAIVLQRGEL QKAALAPVQA APAAGPGCRG LRGRQLRFGH 
      1010       1020       1030       1040       1050
GNGGGSSGSL FELSEGQRGS CGGGGSCGQE ETLPSASRSR RSRASIKSST 
      1060       1070       1080       1090       1100
TEAEHPALLL MAQTMGRRRC RRGSSEAAGA GKAASANKLC RQPKSHVRCL 
      1110       1120       1130       1140       1150
LSCRLMADQQ LRARRREGRE ENRPWRVREF IDPRGLARQT GRRGRPHTDR 
      1160       1170       1180       1190       1200
AGKKSQSEGE GSGREAEFQS AKPRRAPKSI MADPNQPADM AATGGGDGRP 
      1210       1220       1230       1240       1250
RRLKKLPSLG GQAAPGDAGT ALDAAQPGAD GAPRPRRKKK RQPASAADAE 
      1260       1270       1280       1290       1300
ASPDHGTAPI SAQQQLLPAP AAGDDGAATG ATSGGAAAPR PRRKKRRQPA 
      1310       1320       1330       1340       1350
SAAAAAAATA GTDAPEAEEA RRSPEGREAE PAAAAAAPRT RYIDVEGMPL 
      1360       1370       1380       1390       1400
AKALETVRAD VVTREGAGGR VNFGADLADG GPAGDVKADD EDEAAIGGGG 
      1410       1420       1430       1440       1450
GGRAGESNMS DTIFWQTQDA KTFKAEKLDK YQQRLEQERK EREQYLEGVV 
      1460       1470       1480       1490       1500
EEDTSNRTLK CAIGFTKVYN YLGTVLLGLM PGFALLHTVY VWTLSSNYLS 
      1510       1520       1530       1540       1550
FLADYSRLGS PMPILYYVVL TLILLSVLDR YDTGKLDRGS CLECASFRHG 
      1560       1570       1580       1590       1600
GMVVLLYIPA YVVSNAMYPT DQWMRGYSLN ATAYAGIANG DSLVQSWRIM 
      1610       1620       1630       1640       1650
DTVRAACLAL GWLVVAFNPQ FNRLADNLET ELDDLIGEEQ QLEMGAGGAT 
      1660       1670       1680       1690       1700
QAGRTLGPAG RTQAGRTLPA PTPHSPALAG PAAAAAEDEA AAVSLFGDSS 
      1710       1720       1730       1740       1750
GDSSGSAGRS GRSRGIGSSG GSGGGGGSGT QHHAAPVMAA ASRAAVAVAA 
      1760       1770       1780       1790       1800
ADRGGEVLLR LYLCGPSSSH SNAVQRSLGG PGGRPGRPEA DRAAGIDPSI 
      1810       1820       1830       1840       1850
SAALGRELSP VGAGQGNETN KKLLFRVVGG RSCRCQKCKT RTSKLLRIEF 
      1860       1870       1880       1890       1900
PRPNGRQSPH LGAPPPVPPL TNPRKQKLAV FCQEDWSKNK EKARETARNK 
      1910       1920       1930       1940       1950
RGRSSAKAAA EAGEQAELGV PVPGAPSHST GINSGQVQEA AGFIRVGQIG 
      1960       1970       1980       1990       2000
KSGTPTFHLS RISHCRIPGM PRMNAHADMQ NAGMRVAMRF PKTKKATTGS 
      2010       2020       2030       2040       2050
YIQQPEISQH EVQSPDGIFF PKAAGDPTTD AEGRDAGRGL GNEDTKRKDA 
      2060       2070       2080       2090       2100
TGGTEPEEEA SSAQEAAAPP SFLPGTAPAL TAKFWCRFRC AQPPDCRSLT 
      2110       2120       2130       2140       2150
KRPGTAEGRQ RRWWGRESLG GGAAGGGQVS IAREALRHRP AEHNGAGLRS 
      2160       2170       2180       2190       2200
CRGCQTALGS GAEQLGVGGR VRVAVDRPGQ RRSCRGSRRS GHRRGRRRFG 
      2210       2220       2230       2240       2250
GSCRGGRGDS SLQTLRPVLA AIPVVPEVQQ AAAAASADCR IGGCRRAGRR 
      2260       2270       2280       2290       2300
RRRRSLAMTL RLRAGVSSGR RARRRRLLLL RTLAAPVLRA QTERPILEQP 
      2310       2320       2330       2340       2350
AGFLYGLLAN YVADAGEGEP ARPRAVHRRA AVRVAAGGAF PQSAALSGPR 
      2360       2370       2380       2390       2400
GSPRREQMRP GEFRCSFDYP GAGLLKRPSC DCVTSLPHRQ PGAGSASNIA 
      2410       2420       2430
GKSERRHEEE KLLLLVERGS GNRISLCPFV
Length:2,430
Mass (Da):258,817
Last modified:January 18, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2A89388B481892D8
GO

Genome annotation databases

WormBase ParaSite

More...WBParaSitei		maker-uti_cns_0003775-snap-gene-0.2-mRNA-1; maker-uti_cns_0003775-snap-gene-0.2-mRNA-1; maker-uti_cns_0003775-snap-gene-0.2

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

WBParaSiteimaker-uti_cns_0003775-snap-gene-0.2-mRNA-1; maker-uti_cns_0003775-snap-gene-0.2-mRNA-1; maker-uti_cns_0003775-snap-gene-0.2

Family and domain databases

InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR039800, MICU1/2/3
IPR029409, TMEM237
PANTHERiPTHR12294, PTHR12294, 2 hits
PfamiView protein in Pfam
PF15383, TMEM237, 1 hit
SUPFAMiSSF47473, SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1I8GZE5_9PLAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1I8GZE5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 18, 2017
Last sequence update: January 18, 2017
Last modified: February 10, 2021
This is version 17 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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