Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 17 (10 Feb 2021)
Sequence version 1 (18 Jan 2017)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Uncharacterized protein

Gene
N/A
Organism
Macrostomum lignano
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi421 – 432PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi596 – 607PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradationARBA annotation
LigandCalciumPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacrostomum lignanoImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri282301 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaSpiraliaLophotrochozoaPlatyhelminthesRhabditophoraMacrostomorphaMacrostomidaMacrostomidaeMacrostomum
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000095280 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Transmembranei150 – 169HelicalSequence analysisAdd BLAST20
Transmembranei262 – 280HelicalSequence analysisAdd BLAST19
Transmembranei1468 – 1493HelicalSequence analysisAdd BLAST26
Transmembranei1514 – 1531HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell projectionARBA annotation, Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini408 – 443EF-handInterPro annotationAdd BLAST36
Domaini534 – 549EF-handInterPro annotationAdd BLAST16
Domaini583 – 618EF-handInterPro annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni211 – 240DisorderedSequence analysisAdd BLAST30
Regioni754 – 784DisorderedSequence analysisAdd BLAST31
Regioni1007 – 1089DisorderedSequence analysisAdd BLAST83
Regioni1131 – 1340DisorderedSequence analysisAdd BLAST210
Regioni1643 – 1684DisorderedSequence analysisAdd BLAST42
Regioni1696 – 1735DisorderedSequence analysisAdd BLAST40
Regioni1768 – 1794DisorderedSequence analysisAdd BLAST27
Regioni1851 – 1872DisorderedSequence analysisAdd BLAST22
Regioni1888 – 1920DisorderedSequence analysisAdd BLAST33
Regioni1995 – 2074DisorderedSequence analysisAdd BLAST80
Regioni2177 – 2208DisorderedSequence analysisAdd BLAST32

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1421 – 1448Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi226 – 240PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1030 – 1052PolarSequence analysisAdd BLAST23
Compositional biasi1131 – 1172PolyampholyteSequence analysisAdd BLAST42
Compositional biasi1697 – 1717PolarSequence analysisAdd BLAST21
Compositional biasi1858 – 1872Pro-richSequence analysisAdd BLAST15
Compositional biasi1888 – 1907PolyampholyteSequence analysisAdd BLAST20
Compositional biasi1996 – 2011PolarSequence analysisAdd BLAST16
Compositional biasi2028 – 2055PolyampholyteSequence analysisAdd BLAST28
Compositional biasi2184 – 2201BasicSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM237 family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR039800, MICU1/2/3
IPR029409, TMEM237

The PANTHER Classification System

More...
PANTHERi
PTHR12294, PTHR12294, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15383, TMEM237, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473, SSF47473, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1I8GZE5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMSSRRPQSM TRGRASLLLS SHSLASSSTF WLMSKKNALD SCLSCERCRH
60 70 80 90 100
SLVSSWICSS EYLAMAFRSS FFCDSRLARK DLRRSSICAV AFGNRSLYTL
110 120 130 140 150
FISNRSCGPR RTRVRVRAAV LLLLLLLLLL LLLLLLYTMG HSGLRLAGRW
160 170 180 190 200
RVMVMVVVMV VVVRVEVLLG RALAGDVAAL RCVGAVARGG QRGQGPAADV
210 220 230 240 250
RLATLGAQAP AADAGSVDDV DGRDDEADDA GRAEQDRAIS NARKQAVKTV
260 270 280 290 300
SMQGMLRTLL RPAAYAATAV AAVAVAATSV PERRQSRQEH PIQNGLMRLR
310 320 330 340 350
ELRVAAPMLA AATTKPAHGH LEERFLEFAS VEFNDTAYMT PEDFLESVTQ
360 370 380 390 400
DRPRFRRGRK LLSDADVEQM LRKAPSHRRA SKKLMRSLGH DGIVSYSEYL
410 420 430 440 450
FLLCTLANAE SGFSIAFNMI DRSRNQSVEK DEFDILNTMV SECQAEQQQD
460 470 480 490 500
TTLMRHFFGQ SGKDSLDYNR FVEFMSNLQY EVLELEFLEF SKGLPSIPES
510 520 530 540 550
EFARVLLRYT NLSPSTQAVW VDQVRDKLVR EEGIGFEDFR QFFQFLNSLA
560 570 580 590 600
DFSMALQMYA LAGHPVTQDE FQRAVKACVG YTLSPRVVST VFLLLDKDGD
610 620 630 640 650
GSLSSDELLA ILKGRLKRLI HLLPQHVLLD ALPVPLPRGV LAIAAVAVPA
660 670 680 690 700
PQPGGLALAE QAEELAVGQR PVAVDVEHGE QDRQQLGRHT AASGGHHRPL
710 720 730 740 750
EVLLADGLAG DLKHAQGEEQ VAGVQQELEE LLVLLSCYTF RLPRPVLQQR
760 770 780 790 800
QAEATLGGRQ AGPAKNRAPE VEWRHDGRGG GAQAGPELGQ QHLALQVVGE
810 820 830 840 850
FGELGSRDGV AGVGAEKVHK QAGAGVVVHQ QLGARVSGGA VRRDDAVQPA
860 870 880 890 900
ELVGVQGAVA IAIKGAEGDL EAGAGLGEHI EQQQELRVGD EAVAAEVAEQ
910 920 930 940 950
VVAGAALAGR GAQHRPVFGL GQHVTSTANS ATSLGFGRRF IVAAGVESDG
960 970 980 990 1000
LKEVERAEVG GAIVLQRGEL QKAALAPVQA APAAGPGCRG LRGRQLRFGH
1010 1020 1030 1040 1050
GNGGGSSGSL FELSEGQRGS CGGGGSCGQE ETLPSASRSR RSRASIKSST
1060 1070 1080 1090 1100
TEAEHPALLL MAQTMGRRRC RRGSSEAAGA GKAASANKLC RQPKSHVRCL
1110 1120 1130 1140 1150
LSCRLMADQQ LRARRREGRE ENRPWRVREF IDPRGLARQT GRRGRPHTDR
1160 1170 1180 1190 1200
AGKKSQSEGE GSGREAEFQS AKPRRAPKSI MADPNQPADM AATGGGDGRP
1210 1220 1230 1240 1250
RRLKKLPSLG GQAAPGDAGT ALDAAQPGAD GAPRPRRKKK RQPASAADAE
1260 1270 1280 1290 1300
ASPDHGTAPI SAQQQLLPAP AAGDDGAATG ATSGGAAAPR PRRKKRRQPA
1310 1320 1330 1340 1350
SAAAAAAATA GTDAPEAEEA RRSPEGREAE PAAAAAAPRT RYIDVEGMPL
1360 1370 1380 1390 1400
AKALETVRAD VVTREGAGGR VNFGADLADG GPAGDVKADD EDEAAIGGGG
1410 1420 1430 1440 1450
GGRAGESNMS DTIFWQTQDA KTFKAEKLDK YQQRLEQERK EREQYLEGVV
1460 1470 1480 1490 1500
EEDTSNRTLK CAIGFTKVYN YLGTVLLGLM PGFALLHTVY VWTLSSNYLS
1510 1520 1530 1540 1550
FLADYSRLGS PMPILYYVVL TLILLSVLDR YDTGKLDRGS CLECASFRHG
1560 1570 1580 1590 1600
GMVVLLYIPA YVVSNAMYPT DQWMRGYSLN ATAYAGIANG DSLVQSWRIM
1610 1620 1630 1640 1650
DTVRAACLAL GWLVVAFNPQ FNRLADNLET ELDDLIGEEQ QLEMGAGGAT
1660 1670 1680 1690 1700
QAGRTLGPAG RTQAGRTLPA PTPHSPALAG PAAAAAEDEA AAVSLFGDSS
1710 1720 1730 1740 1750
GDSSGSAGRS GRSRGIGSSG GSGGGGGSGT QHHAAPVMAA ASRAAVAVAA
1760 1770 1780 1790 1800
ADRGGEVLLR LYLCGPSSSH SNAVQRSLGG PGGRPGRPEA DRAAGIDPSI
1810 1820 1830 1840 1850
SAALGRELSP VGAGQGNETN KKLLFRVVGG RSCRCQKCKT RTSKLLRIEF
1860 1870 1880 1890 1900
PRPNGRQSPH LGAPPPVPPL TNPRKQKLAV FCQEDWSKNK EKARETARNK
1910 1920 1930 1940 1950
RGRSSAKAAA EAGEQAELGV PVPGAPSHST GINSGQVQEA AGFIRVGQIG
1960 1970 1980 1990 2000
KSGTPTFHLS RISHCRIPGM PRMNAHADMQ NAGMRVAMRF PKTKKATTGS
2010 2020 2030 2040 2050
YIQQPEISQH EVQSPDGIFF PKAAGDPTTD AEGRDAGRGL GNEDTKRKDA
2060 2070 2080 2090 2100
TGGTEPEEEA SSAQEAAAPP SFLPGTAPAL TAKFWCRFRC AQPPDCRSLT
2110 2120 2130 2140 2150
KRPGTAEGRQ RRWWGRESLG GGAAGGGQVS IAREALRHRP AEHNGAGLRS
2160 2170 2180 2190 2200
CRGCQTALGS GAEQLGVGGR VRVAVDRPGQ RRSCRGSRRS GHRRGRRRFG
2210 2220 2230 2240 2250
GSCRGGRGDS SLQTLRPVLA AIPVVPEVQQ AAAAASADCR IGGCRRAGRR
2260 2270 2280 2290 2300
RRRRSLAMTL RLRAGVSSGR RARRRRLLLL RTLAAPVLRA QTERPILEQP
2310 2320 2330 2340 2350
AGFLYGLLAN YVADAGEGEP ARPRAVHRRA AVRVAAGGAF PQSAALSGPR
2360 2370 2380 2390 2400
GSPRREQMRP GEFRCSFDYP GAGLLKRPSC DCVTSLPHRQ PGAGSASNIA
2410 2420 2430
GKSERRHEEE KLLLLVERGS GNRISLCPFV
Length:2,430
Mass (Da):258,817
Last modified:January 18, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2A89388B481892D8
GO

Genome annotation databases

WormBase ParaSite

More...
WBParaSitei
maker-uti_cns_0003775-snap-gene-0.2-mRNA-1; maker-uti_cns_0003775-snap-gene-0.2-mRNA-1; maker-uti_cns_0003775-snap-gene-0.2

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

WBParaSiteimaker-uti_cns_0003775-snap-gene-0.2-mRNA-1; maker-uti_cns_0003775-snap-gene-0.2-mRNA-1; maker-uti_cns_0003775-snap-gene-0.2

Family and domain databases

InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR039800, MICU1/2/3
IPR029409, TMEM237
PANTHERiPTHR12294, PTHR12294, 2 hits
PfamiView protein in Pfam
PF15383, TMEM237, 1 hit
SUPFAMiSSF47473, SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1I8GZE5_9PLAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1I8GZE5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 18, 2017
Last sequence update: January 18, 2017
Last modified: February 10, 2021
This is version 17 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again