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Entry version 24 (12 Aug 2020)
Sequence version 1 (18 Jan 2017)
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Protein

Tyrosine-protein kinase

Gene
N/A
Organism
Caenorhabditis tropicalis
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseUniRule annotationARBA annotation
LigandATP-bindingUniRule annotationARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis tropicalisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1561998 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000095282 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Whole Genome Shotgun Assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projectionARBA annotation, CytoplasmARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
1561998.Csp11.Scaffold629.g8483.t1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini87 – 431FERMInterPro annotationAdd BLAST345
Domaini1015 – 1111SH2InterPro annotationAdd BLAST97
Domaini1123 – 1378Protein kinaseInterPro annotationAdd BLAST256

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni142 – 179DisorderedSequence analysisAdd BLAST38

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0194, Eukaryota
KOG4261, Eukaryota

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14473, FERM_B-lobe, 1 hit
cd10361, SH2_Fps_family, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.80.10, 1 hit
2.30.29.30, 1 hit
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019749, Band_41_domain
IPR014352, FERM/acyl-CoA-bd_prot_sf
IPR035963, FERM_2
IPR019748, FERM_central
IPR019747, FERM_CS
IPR000299, FERM_domain
IPR032425, FERM_f0
IPR018979, FERM_N
IPR035849, Fes/Fps/Fer_SH2
IPR035964, I/LWEQ_dom_sf
IPR002558, ILWEQ_dom
IPR011009, Kinase-like_dom_sf
IPR011993, PH-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR015224, Talin_cent
IPR036476, Talin_cent_sf
IPR008266, Tyr_kinase_AS
IPR020635, Tyr_kinase_cat_dom
IPR029071, Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16511, FERM_f0, 1 hit
PF00373, FERM_M, 1 hit
PF09379, FERM_N, 1 hit
PF01608, I_LWEQ, 1 hit
PF07714, Pkinase_Tyr, 1 hit
PF00017, SH2, 1 hit
PF09141, Talin_middle, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00109, TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295, B41, 1 hit
SM00252, SH2, 1 hit
SM00219, TyrKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109880, SSF109880, 1 hit
SSF109885, SSF109885, 2 hits
SSF47031, SSF47031, 1 hit
SSF54236, SSF54236, 1 hit
SSF55550, SSF55550, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00660, FERM_1, 1 hit
PS00661, FERM_2, 1 hit
PS50057, FERM_3, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit
PS50001, SH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1I7UEE3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGVLSLTVSC SEKGIKKTMQ FGPDTLVYDA CKLIREKFGM NDVNSQEYGL
60 70 80 90 100
FRVDSDPTKA LWMDNGRSFE HYLIRNKDEV EYKRKIRHLK VRMLDGAVKT
110 120 130 140 150
VNVDESQPVS QLMLTICNKI GISNYDEYSL VRYDILAEEK AAQNGGSGGG
160 170 180 190 200
GGGSTWNLRD KDNRSKSSDR GGGVYGTMRR KNEAKLEELR KKHHTDEELP
210 220 230 240 250
WLDHQKTLRE QGISEEETLI LRRKLFFSDS NVDSRDPVQL NLLYVQCRDG
260 270 280 290 300
ILRGLHPVEK ETALELGALL SHIQFGDFPH DKQKFTIDGR DCLPKEYAKN
310 320 330 340 350
KENEKKVLML YKELSGTSEL DAKSKYVHLC RGLKTYGVTF FVVKERLPGK
360 370 380 390 400
NKLVPRLLGV NKESVMRVDE KTKEIMKEWP LEQVRRWVPA PTCFTLDFGD
410 420 430 440 450
YQDGYYSVKT TDGEKIAQLI QGYVDIILKK KKTQDHQGIE GDEGSTMLED
460 470 480 490 500
MVAPAKATLV AHGQIGSGQH AQDGLVAVRG VLRTPQGGQG YGINGAQYGA
510 520 530 540 550
VSGEITSQEL ARAQRLRYQD MYQHPQRALI GTIEATIRAV DEAEEELEAE
560 570 580 590 600
PQIDIPRFND DASQNRWMEE QRAVNKENVN ERLAAMGAAT AQVVQWTAVE
610 620 630 640 650
EYDDRVGSAI ATIGSNLPDV SRNVRDLGAF METRERGDLV EATRRLCGAF
660 670 680 690 700
GDFLTAVNPE QNERRNKVFT AAGRVGEYSQ QVINRMDPPS DHQQQFDDYL
710 720 730 740 750
VQRAKNVATS TAQLVLCAKT ISAECNEPQV QERVIQSATK CAFATSQLVA
760 770 780 790 800
CARVVAPTID NNACQEQLTT ASTEVSQSVK NLLHDAESAV YERSSLTDIH
810 820 830 840 850
EAARQVTSAL DSLLEHAKCS PKTMTTRREE EEMYNEVLRR TNRMVVHQGP
860 870 880 890 900
SEDLTREARR VVRHSQLLTE QFQHEAHQRP EHRDRLLDAA AKVAHATSEM
910 920 930 940 950
ILATEQAESH PRQVDNEYAL RTAAENLGKV TNETTREQQE QHIMQRLEQA
960 970 980 990 1000
AKQTAYXXXX XXXXXXXXXX XXXCCTAERT ECTNKKNKKE SSQMGTIEKS
1010 1020 1030 1040 1050
TNDASVTDDI RGADYYHGMV PRQDAEGFLK REGDFLVRKT EQTPGKVVLA
1060 1070 1080 1090 1100
LSVRVTDDLC RHFMLNMDPN TNKFYFEFTH QESTIPDLIN WHMTTKTPIS
1110 1120 1130 1140 1150
AASGAKIRRP MERSPWLINH DSIVANKKLG EGAFGDVFIA ELEQGGKQEV
1160 1170 1180 1190 1200
AVKTMRAEAT REARLRFMKE ARLMRKYQHK HVVKFLGVAI HEHPLMIVME
1210 1220 1230 1240 1250
YCPNGSLLSH LKKNKVSPAD KLRFTTEAAD GIAYLERSKC IHRDIAARNC
1260 1270 1280 1290 1300
LLSQKNELKI SDFGMSDNKD EIKDEALEKV PVKWLAPETL QDKVYTHKTD
1310 1320 1330 1340 1350
IWTFGILVWE IYSDGAEPYP GLTKVQTRAK LVVSDYRMKM PDGTPPTVAE
1360 1370 1380
VITGTCWQKN PEKRTTMDAI HKKLREFYDK K
Length:1,381
Mass (Da):156,246
Last modified:January 18, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8FEA26F6904F1719
GO

Genome annotation databases

WormBase ParaSite

More...
WBParaSitei
Csp11.Scaffold629.g8483.t1; Csp11.Scaffold629.g8483.t1; Csp11.Scaffold629.g8483

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Protein-protein interaction databases

STRINGi1561998.Csp11.Scaffold629.g8483.t1

Genome annotation databases

WBParaSiteiCsp11.Scaffold629.g8483.t1; Csp11.Scaffold629.g8483.t1; Csp11.Scaffold629.g8483

Phylogenomic databases

eggNOGiKOG0194, Eukaryota
KOG4261, Eukaryota

Family and domain databases

CDDicd14473, FERM_B-lobe, 1 hit
cd10361, SH2_Fps_family, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR019749, Band_41_domain
IPR014352, FERM/acyl-CoA-bd_prot_sf
IPR035963, FERM_2
IPR019748, FERM_central
IPR019747, FERM_CS
IPR000299, FERM_domain
IPR032425, FERM_f0
IPR018979, FERM_N
IPR035849, Fes/Fps/Fer_SH2
IPR035964, I/LWEQ_dom_sf
IPR002558, ILWEQ_dom
IPR011009, Kinase-like_dom_sf
IPR011993, PH-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR015224, Talin_cent
IPR036476, Talin_cent_sf
IPR008266, Tyr_kinase_AS
IPR020635, Tyr_kinase_cat_dom
IPR029071, Ubiquitin-like_domsf
PfamiView protein in Pfam
PF16511, FERM_f0, 1 hit
PF00373, FERM_M, 1 hit
PF09379, FERM_N, 1 hit
PF01608, I_LWEQ, 1 hit
PF07714, Pkinase_Tyr, 1 hit
PF00017, SH2, 1 hit
PF09141, Talin_middle, 1 hit
PRINTSiPR00109, TYRKINASE
SMARTiView protein in SMART
SM00295, B41, 1 hit
SM00252, SH2, 1 hit
SM00219, TyrKc, 1 hit
SUPFAMiSSF109880, SSF109880, 1 hit
SSF109885, SSF109885, 2 hits
SSF47031, SSF47031, 1 hit
SSF54236, SSF54236, 1 hit
SSF55550, SSF55550, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00660, FERM_1, 1 hit
PS00661, FERM_2, 1 hit
PS50057, FERM_3, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit
PS50001, SH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1I7UEE3_9PELO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1I7UEE3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 18, 2017
Last sequence update: January 18, 2017
Last modified: August 12, 2020
This is version 24 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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