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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Streptomyces mirabilis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei736ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
ORF Names:SAMN02787118_12847Imported
OrganismiStreptomyces mirabilisImported
Taxonomic identifieri68239 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000181942 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 148tRNA-synt_1gInterPro annotationAdd BLAST82
Domaini299 – 503tRNA-synt_1_2InterPro annotationAdd BLAST205
Domaini811 – 922Anticodon_1InterPro annotationAdd BLAST112

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi733 – 737"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Family and domain databases

Gene3Di3.40.50.620, 3 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1I2UJT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETNPAAAS EVAAPHRYTA AMAAEIEARW QDFWDAEGTY EAPNPSGDLA
60 70 80 90 100
GDPELAAKPK KFIMDMFPYP SGAGLHVGHP LGYIATDVFA RFQRMTGHNV
110 120 130 140 150
LHTLGFDAFG LPAEQYAVQT GTHPRVSTEA NIENMKAQLR ALGLGHDRRR
160 170 180 190 200
SFATIDPGYY KWTQWIFLQI FNSWYDDEAD KARPISVLIA QFESGERAVP
210 220 230 240 250
SVDGATRAWN ELTATERADI LSEYRLAYAS DAPVNWSPGL GTVLANEEVT
260 270 280 290 300
ADGRSERGNF PVFKAKLRQW NMRITAYADR LLDDLEALDW PEAIKLQQRN
310 320 330 340 350
WIGRSEGARV DFPIDGEAIT VFTTRPDTLF GATYMVLAPE HPLVDKFVPE
360 370 380 390 400
AWPEGSHEVW TGGHATPAEA VAGYRAQAAS KSDVERQAEA KDKTGVFTGA
410 420 430 440 450
YATNPVNGEQ IPVFIADYVL MGYGTGAIMA VPAGDQRDFE FARAFELPIR
460 470 480 490 500
CIVEPTDGRG TDTSTWENAF GAYDAKIINS SNDDISLDGL AVAEAKERIT
510 520 530 540 550
EWLARKGIGE GTVNFRLRDW LFSRQRYWGE PFPIVYDEDG VAHALPESML
560 570 580 590 600
PLELPEVEDY SPRTFDPDDA NTSPETPLSR NEDWVNVTLD LGDGRGPQKY
610 620 630 640 650
RRETNTMPNW AGSCWYELRY LDPHNDQKLV DPAIEQYWMG PREGQPHGGV
660 670 680 690 700
DLYVGGAEHA VLHLLYARFW SKVLYDLGYV SSVEPFHKLF NQGMIQAFVY
710 720 730 740 750
RDSRGIAVPA AEVEERDGAY YYQGERVSRL LGKMGKSLKN AVTPDEICAE
760 770 780 790 800
YGADTLRLYE MAMGPLDVSR PWDTRAVVGQ YRLLQRLWRN VVDETTGEVT
810 820 830 840 850
VADTPAGEDT LRALHKAIDG VHQDLEGLRF NTAIAKVTEL NNHLTKVGGP
860 870 880 890 900
VSRTVAERLV LLIAPLAPHI AEELWRKLGH TDSVVHQDFP VADPAYVVDE
910 920 930 940 950
AVTCVVQIKG KVKARLEVSP SISDADLEKI ALADEKVVAA LDGAGIRKVI
960
VRAPKLVNIV TA
Length:962
Mass (Da):106,703
Last modified:April 12, 2017 - v1
Checksum:i460D3FF2CD7E4EFE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FONR01000028 Genomic DNA Translation: SFG77300.1
RefSeqiWP_075032717.1, NZ_FONR01000028.1

Similar proteinsi

Entry informationi

Entry nameiA0A1I2UJT7_9ACTN
AccessioniPrimary (citable) accession number: A0A1I2UJT7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: March 28, 2018
This is version 10 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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