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Entry version 11 (11 Dec 2019)
Sequence version 1 (22 Nov 2017)
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Protein

Thymidylate kinase

Gene

tmk

Organism
Streptomyces alni
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi517 – 524ATPUniRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseUniRule annotationSAAS annotationImported, Transferase
Biological processNucleotide biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tmkUniRule annotation
ORF Names:SAMN05216251_125101Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptomyces alniImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri380248 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000199323 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei52 – 70HelicalSequence analysisAdd BLAST19
Transmembranei82 – 105HelicalSequence analysisAdd BLAST24
Transmembranei125 – 144HelicalSequence analysisAdd BLAST20
Transmembranei208 – 233HelicalSequence analysisAdd BLAST26
Transmembranei295 – 316HelicalSequence analysisAdd BLAST22
Transmembranei328 – 346HelicalSequence analysisAdd BLAST19
Transmembranei358 – 377HelicalSequence analysisAdd BLAST20
Transmembranei383 – 404HelicalSequence analysisAdd BLAST22
Transmembranei425 – 447HelicalSequence analysisAdd BLAST23
Transmembranei459 – 479HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini515 – 698Thymidylate_kinInterPro annotationAdd BLAST184

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni803 – 1093DisorderedSequence analysisAdd BLAST291

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi803 – 856PolyampholyteSequence analysisAdd BLAST54
Compositional biasi937 – 955PolarSequence analysisAdd BLAST19
Compositional biasi973 – 987PolarSequence analysisAdd BLAST15
Compositional biasi1051 – 1068PolyampholyteSequence analysisAdd BLAST18
Compositional biasi1078 – 1093PolyampholyteSequence analysisAdd BLAST16

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_00165 Thymidylate_kinase, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036259 MFS_trans_sf
IPR027417 P-loop_NTPase
IPR039430 Thymidylate_kin-like_dom
IPR018095 Thymidylate_kin_CS
IPR018094 Thymidylate_kinase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02223 Thymidylate_kin, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473 SSF103473, 1 hit
SSF52540 SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00041 DTMP_kinase, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01331 THYMIDYLATE_KINASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1I2KZ41-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPSQQQPAA DVTVTDAFAT DLAADSRERA VGALLKIPAL RKLWSAQLTG
60 70 80 90 100
AVADRLGLLV LLWLAVQAAA ADGAYGGGYR GVSLAVAAVF AARLVATLLF
110 120 130 140 150
GAVLLGPLSA LTAEGGKLDR RWTMIGADAV RLGLFIVAPL WITWSQHNAL
160 170 180 190 200
TWLLVTAFVT GIAERLWAVA KDGAAPLLLP PPGDTSVRPA PDHLATLHRL
210 220 230 240 250
DLRTSFSALP LAAAAMVVVT LVNTLIAVGV TWFDQHQVAL SSYVAAGLFS
260 270 280 290 300
SSMSVLYLLE LPSGTVARPR SPLEGLRLPK GPAGAERGRT GALPLLVLAT
310 320 330 340 350
AAVVGAIGTA VAVSVLHALD LGFGPTGFGL LVLALTAGTV CGIRLAPRTL
360 370 380 390 400
PALSRRRLLA LSIGITGLGL LLTGIVADQT TVLLLALLTG AAAGVTANTG
410 420 430 440 450
HVLIEQEAEA GRRGRTTEHL HAVSRAVLAV AVIAGPAVAG AIGPHRIQKG
460 470 480 490 500
HFTFDHGGAA YTLMLVGALL LPVAALVLGK TDDRSGVPLR RDLREALTGA
510 520 530 540 550
EPAVAPAATG FFIAIEGGDG AGKSTQVEAL AEWIRAKGHE VVVTREPGAT
560 570 580 590 600
AIGKRLRSIL LDVASGGISH RAEALLYAAD RAEHIDTVVR PALERGAVVI
610 620 630 640 650
SDRYIDSSVA YQGAGRDLAP TEIARISRWA TDGLVPHLTV LLDVSPEAAR
660 670 680 690 700
ERFTEAPDRL ESEPAAFHQR VRAGFLTLAA ADPGRYLVVD GGQDPADVTT
710 720 730 740 750
VVRHRLDQLL PLSEQEIEAR AEAERQAAAE AARLAAEEAA RKAEEERLER
760 770 780 790 800
ERQEQLERLR REEEERRLAA EEEARREIAE RAAAREAEAA RLRAEEEARV
810 820 830 840 850
AAEETARREA EEAARAAEQE RLRRLAEEQA RLRAEAEERR LEKQRKAEEA
860 870 880 890 900
LLRAERARTE AAAAAAAAAA AAESGGTEET TEVTALPVEP VEPAEPGASS
910 920 930 940 950
SDTTLVNVVP AVPDAEKTAV LRAVPAEEAD SEETTVLPAV TEDSSETTVL
960 970 980 990 1000
PAVTEDSSET XXXXXXXXXX AVTEDSSETT VLPAVTEDSS ETAVLPAVPA
1010 1020 1030 1040 1050
EEAAEAEEEP GDGSETTTVM PPVVPPTGSP AADDPTDRVP PWLFRPEDQP
1060 1070 1080 1090
GASPDRPRRP RPDWAEETPL DDLPTLADEL LGPHDDDPPP ARR
Length:1,093
Mass (Da):115,137
Last modified:November 22, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5C2E2B181A87A037
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FONG01000025 Genomic DNA Translation: SFF71589.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FONG01000025 Genomic DNA Translation: SFF71589.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Family and domain databases

HAMAPiMF_00165 Thymidylate_kinase, 1 hit
InterProiView protein in InterPro
IPR036259 MFS_trans_sf
IPR027417 P-loop_NTPase
IPR039430 Thymidylate_kin-like_dom
IPR018095 Thymidylate_kin_CS
IPR018094 Thymidylate_kinase
PfamiView protein in Pfam
PF02223 Thymidylate_kin, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00041 DTMP_kinase, 1 hit
PROSITEiView protein in PROSITE
PS01331 THYMIDYLATE_KINASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1I2KZ41_9ACTN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1I2KZ41
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2017
Last sequence update: November 22, 2017
Last modified: December 11, 2019
This is version 11 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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