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Protein

2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase

Gene

menD

Organism
Arthrobacter sp. yr096
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).UniRule annotationSAAS annotation

Catalytic activityi

Isochorismate + 2-oxoglutarate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2.UniRule annotationSAAS annotation

Cofactori

Mn2+SAAS annotation

Pathwayi: 1,4-dihydroxy-2-naphthoate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate.UniRule annotationSAAS annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (menD)
  3. no protein annotated in this organism
  4. o-succinylbenzoate synthase (menC), o-succinylbenzoate synthase (menC)
  5. no protein annotated in this organism
  6. 1,4-dihydroxy-2-naphthoyl-CoA synthase (menB)
  7. no protein annotated in this organism
This subpathway is part of the pathway 1,4-dihydroxy-2-naphthoate biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate, the pathway 1,4-dihydroxy-2-naphthoate biosynthesis and in Quinol/quinone metabolism.

Pathwayi: menaquinone biosynthesis

This protein is involved in the pathway menaquinone biosynthesis, which is part of Quinol/quinone metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationSAAS annotation
Biological processMenaquinone biosynthesisUniRule annotation
LigandMagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Thiamine pyrophosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00079
UPA01057; UER00164

Names & Taxonomyi

Protein namesi
Recommended name:
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthaseUniRule annotationSAAS annotation (EC:2.2.1.9UniRule annotation)
Short name:
SEPHCHC synthaseUniRule annotation
Alternative name(s):
Menaquinone biosynthesis protein MenDUniRule annotation
Gene namesi
Name:menDUniRule annotation
ORF Names:SAMN04487917_101217Imported
OrganismiArthrobacter sp. yr096Imported
Taxonomic identifieri1761750 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeArthrobacter
Proteomesi
  • UP000199697 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 175TPP_enzyme_NInterPro annotationAdd BLAST163
Domaini403 – 536TPP_enzyme_CInterPro annotationAdd BLAST134

Sequence similaritiesi

Belongs to the TPP enzyme family. MenD subfamily.UniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_01659 MenD, 1 hit
InterProiView protein in InterPro
IPR004433 MenaQ_synth_MenD
IPR029061 THDP-binding
IPR012001 Thiamin_PyroP_enz_TPP-bd_dom
IPR011766 TPP_enzyme-bd_C
PANTHERiPTHR42916 PTHR42916, 1 hit
PfamiView protein in Pfam
PF02775 TPP_enzyme_C, 1 hit
PF02776 TPP_enzyme_N, 1 hit
PIRSFiPIRSF004983 MenD, 1 hit
SUPFAMiSSF52518 SSF52518, 2 hits
TIGRFAMsiTIGR00173 menD, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1H6QG50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSQDSLTSI AAARIAVTTL LDGGVRHAVV APGSRSAPLA YALAEAEAAG
60 70 80 90 100
RVRLHVRIDE RDAGFTALGL ALSTEAPVAV VTTSGTAVGN LLPAVMEANH
110 120 130 140 150
SAVPVVVVSA DRPEELHGTG ANQTTIQLDL FGEHVRFAVD VPAGDHPQKA
160 170 180 190 200
IATALYAATG ALEDTPPGPV QVNLAFRDPL VPGVGDALPE TAGHGVFHYD
210 220 230 240 250
AGPQALDLPA ALTDLPVRRA VVLAGHDAGA VAEAFARAHG LPLLAEPSSN
260 270 280 290 300
ARFGPNAVGP YRVLLEHFGP GSPAPIERVV LFGRATLSRP VSALLARESV
310 320 330 340 350
ESAIYQPVPV AWYEAGRRRE KPIETLPELA AFAGRGSSDW LDSWLLAGAA
360 370 380 390 400
AQHALDSTLD AEDLANGPSV GATVWEHSRG QLVLGSSNGI RDVDLAGQPH
410 420 430 440 450
TEPLATVYAN RGLAGIDGTI ATATGIALGS GRETTVLLGD VTFLHDAGGL
460 470 480 490 500
FLGHGEPVPD LRIVVLNDSG GAIFALLEHG AVDDSGAYGT AVERLFGTPH
510 520 530 540 550
SVDIAALAAA YGVGHQTVST TAELADALKS PLKGRTIVEV RVDRTGLRAL
560
HARIKEAINA AVGQVLTAG
Length:569
Mass (Da):58,453
Last modified:November 22, 2017 - v1
Checksum:i1A8DAC000BE24347
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FNYI01000001 Genomic DNA Translation: SEI42673.1

Similar proteinsi

Entry informationi

Entry nameiA0A1H6QG50_9MICC
AccessioniPrimary (citable) accession number: A0A1H6QG50
Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2017
Last sequence update: November 22, 2017
Last modified: July 18, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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