Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Thiamine thiazole synthase

Gene

thi4

Organism
Halopenitus persicus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Cofactori

Fe2+UniRule annotation

Pathwayi: thiamine diphosphate biosynthesis

This protein is involved in the pathway thiamine diphosphate biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei43NADUniRule annotation1
Binding sitei70NAD; via amide nitrogen and carbonyl oxygenUniRule annotation1
Metal bindingi168Iron; shared with adjacent protomerUniRule annotation1
Binding sitei168NAD; shared with adjacent protomerUniRule annotation1
Metal bindingi183IronUniRule annotation1
Binding sitei258NAD; via amide nitrogenUniRule annotation1
Binding sitei268GlycineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi62 – 63NADUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotation
Biological processThiamine biosynthesisUniRule annotation
LigandIronUniRule annotation, Metal-bindingUniRule annotation, NADUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00060

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine thiazole synthaseUniRule annotation (EC:4.-.-.-UniRule annotation)
Gene namesi
Name:thi4UniRule annotation
ORF Names:SAMN05216564_104191Imported
OrganismiHalopenitus persicusImported
Taxonomic identifieri1048396 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHaloferacalesHalorubraceaeHalopenitus
Proteomesi
  • UP000199079 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

Homooctamer; tetramer of dimers.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the THI4 family.UniRule annotation

Family and domain databases

Gene3Di3.50.50.60, 1 hit
HAMAPiMF_00304 Thi4, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR002922 Thi4_fam
IPR022828 Thi4_prok
SUPFAMiSSF51905 SSF51905, 2 hits
TIGRFAMsiTIGR00292 TIGR00292, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1H3IPP3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNDFDSFSDV SEANVTKAIG NAWSEEFQEF TESEVIIVGG GPSGLMAAKE
60 70 80 90 100
LAERGVKVMV VEKNNYLGGG FWLGGFLMNK VTVRDPAQEI LEELDVDYEP
110 120 130 140 150
TEEAEGLYVS NGPEACSGLI KAACDAGAKI QNMTEFTDIV VRDDHRVGGI
160 170 180 190 200
VMNWTPVHAL PREITCVDPI AVESDLVIDA TGHEAVAISK LDERGVFEAP
210 220 230 240 250
GIEHAKEHNT GMDATGDDQY GAPGHDSPGH DSMWVSESED AVVDHTGVVH
260 270 280 290 300
DGLIATGMSV ATAYGLPRMG PTFGAMLVSG KRAAQSAIDE LGVDAADVGF

SSPAPADD
Length:308
Mass (Da):32,541
Last modified:November 22, 2017 - v1
Checksum:iEFD89BBEA036828F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FNPC01000004 Genomic DNA Translation: SDY29078.1
RefSeqiWP_021075188.1, NZ_FNPC01000004.1

Similar proteinsi

Entry informationi

Entry nameiA0A1H3IPP3_9EURY
AccessioniPrimary (citable) accession number: A0A1H3IPP3
Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2017
Last sequence update: November 22, 2017
Last modified: January 31, 2018
This is version 3 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again