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Protein

Succinylglutamate desuccinylase

Gene

astE

Organism
Pseudomonas sihuiensis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transforms N2-succinylglutamate into succinate and glutamate.UniRule annotationSAAS annotation

Catalytic activityi

N-succinyl-L-glutamate + H2O = succinate + L-glutamate.UniRule annotationSAAS annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-arginine degradation via AST pathway

This protein is involved in step 5 of the subpathway that synthesizes L-glutamate and succinate from L-arginine.UniRule annotationSAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Arginine N-succinyltransferase (SAMN05216363_0567), Arginine N-succinyltransferase (SAMN05216363_0566)
  2. N-succinylarginine dihydrolase (astB)
  3. no protein annotated in this organism
  4. N-succinylglutamate 5-semialdehyde dehydrogenase (astD)
  5. Succinylglutamate desuccinylase (astE)
This subpathway is part of the pathway L-arginine degradation via AST pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate and succinate from L-arginine, the pathway L-arginine degradation via AST pathway and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59ZincUniRule annotation1
Metal bindingi62ZincUniRule annotation1
Metal bindingi152ZincUniRule annotation1
Active sitei216UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processArginine metabolismUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00185; UER00283

Names & Taxonomyi

Protein namesi
Recommended name:
Succinylglutamate desuccinylaseUniRule annotationSAAS annotation (EC:3.5.1.96UniRule annotationSAAS annotation)
Gene namesi
Name:astEUniRule annotation
ORF Names:SAMN05216363_0571Imported
OrganismiPseudomonas sihuiensisImported
Taxonomic identifieri1274359 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000198675 Componenti: Chromosome i

Family & Domainsi

Sequence similaritiesi

Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.UniRule annotationSAAS annotation

Family and domain databases

CDDicd03855 M14_ASTE, 1 hit
HAMAPiMF_00767 Arg_catab_AstE, 1 hit
InterProiView protein in InterPro
IPR007036 Aste_AspA
IPR016681 SuccinylGlu_desuccinylase
PfamiView protein in Pfam
PF04952 AstE_AspA, 1 hit
PIRSFiPIRSF017020 AstE, 1 hit
TIGRFAMsiTIGR03242 arg_catab_astE, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1H2L8W4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLALGKLLEL TLAGHEPSAK IQLTPDGTRL RWLDEGALEV TPPAARDNGL
60 70 80 90 100
DLLLSAGVHG NETAPIELLD RLLRGIARNE LHPAARILFL FGNPEAMRRG
110 120 130 140 150
ERYIEQDLNR LFSGRHEQSS GFEAIRACDL EHLAATFFGK QTGRTRLHYD
160 170 180 190 200
LHTAIRGSKI EQFALYPWQE GRAHSRRELE RLRAAGIEAV LLQNKSSITF
210 220 230 240 250
SAYTYAQLGA EAFTLELGKA RAFGQNELVN LDLLENALHA LIEGREAISG
260 270 280 290 300
EATLDGLQLF SVSREVIKHS DSFQLHLPED IENFTELEPG YLLAEDIADS
310 320 330
RWIVEEKGAR IIFPNPKVKN GLRAAILIVP DDGAGLL
Length:337
Mass (Da):37,392
Last modified:January 18, 2017 - v1
Checksum:i31AED93C240F4350
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT629797 Genomic DNA Translation: SDU77011.1

Similar proteinsi

Entry informationi

Entry nameiA0A1H2L8W4_9PSED
AccessioniPrimary (citable) accession number: A0A1H2L8W4
Entry historyiIntegrated into UniProtKB/TrEMBL: January 18, 2017
Last sequence update: January 18, 2017
Last modified: October 25, 2017
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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